Systematic Screening of Human ABCC3 Polymorphisms and Their Effects on MRP3 Expression and Function

Drug Metabolism and Pharmacokinetics - Tập 26 - Trang 374-386 - 2011
Tomohiro Sasaki1, Takeshi Hirota1, Yuriko Ryokai1, Daisuke Kobayashi1, Miyuki Kimura2, Shin Irie2, Shun Higuchi1, Ichiro Ieiri1
1Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
2Kyushu Clinical Pharmacology Research Clinic, Fukuoka, Japan

Tài liệu tham khảo

Kool, 1997, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines, Cancer Res., 57, 3537 Borst, 1999, The multidrug resistance protein family, Biochim. Biophys. Acta, 1461, 347, 10.1016/S0005-2736(99)00167-4 König, 1999, Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane, Hepatology, 29, 1156, 10.1002/hep.510290404 Inokuchi, 2001, Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter, J. Biol. Chem., 276, 46822, 10.1074/jbc.M104612200 Hirohashi, 1999, Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3), J. Biol. Chem., 274, 15181, 10.1074/jbc.274.21.15181 Kitamura, 2010, Functional characterization of multidrug resistance-associated protein 3 (Mrp3/Abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine, J. Pharmacol. Exp. Ther., 332, 659, 10.1124/jpet.109.156943 Zamek-Gliszczynski, 2006, Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3−/−and Abcc4−/−mice, J. Pharmacol. Exp. Ther., 319, 1485, 10.1124/jpet.106.110106 Hirouchi, 2009, Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multi-drug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4, Drug Metab. Dispos., 37, 2103, 10.1124/dmd.109.027193 Kitamura, 2008, Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3), J. Pharmacol. Exp. Ther., 327, 465, 10.1124/jpet.108.140475 Tian, 2008, Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers, Drug Metab. Dispos., 36, 911, 10.1124/dmd.107.019273 Hitzl, 2003, Influence of omeprazole on multidrug resistance protein 3 expression in human liver, J. Pharmacol. Exp. Ther., 304, 524, 10.1124/jpet.102.043547 Müller, 2009, Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients, Int. J. Cancer, 124, 1669, 10.1002/ijc.23956 Hirota, 2004, Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status, Hum. Mol. Genet., 13, 2959, 10.1093/hmg/ddh313 Garrett, 1993, Pharmacokinetics and bioavailabilities of hymecromone in human volunteers, Biopharm. Drug Dispos., 14, 13, 10.1002/bdd.2510140103 Lang, 2004, Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver, Pharmacogenetics, 14, 155, 10.1097/00008571-200403000-00003 Fukushima-Uesaka, 2007, Genetic variations of the ABC transporter gene ABCC3 in a Japanese population, Drug Metab. Pharmacokinet., 22, 129, 10.2133/dmpk.22.129 Chayka, 2005, v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter, Mol. Cell. Biol., 25, 499, 10.1128/MCB.25.1.499-511.2005 Gradhand, 2007, Functional analysis of the polymorphism –211C>T in the regulatory region of the human ABCC3 gene, Life Sci., 80, 1490, 10.1016/j.lfs.2007.01.023 Zamek-Gliszczynski, 2006, Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat, J. Pharmacol. Exp. Ther., 319, 459, 10.1124/jpet.106.101840 Müller, 2008, Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups, Leuk. Res., 32, 919, 10.1016/j.leukres.2007.10.011 Liu, 2005, Expression profiling of ABC transporters in a drug-resistant breast cancer cell line using AmpArray, Mol. Pharmacol., 68, 430, 10.1124/mol.105.011015 Hanada, 2008, Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression, J. Pathol., 216, 75, 10.1002/path.2383 O’Brien, 2008, Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer, Cancer Res., 68, 5380, 10.1158/0008-5472.CAN-08-0234