Synthetic Pyrrole-Imidazole Polyamide Inhibits Expression of the Human Transforming Growth Factor-β1 Gene

Ando H, Fukuda N, Kotani M, Yokoyama S, Kunimoto S, Matsumoto K, Saito S, Kanmatsuse K, and Mugishima H (2004) Chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-β1 mRNA inhibits neointima formation in rat carotid artery after balloon injury. Eur J Pharmacol 483: 207-214.

Berger SL and Felsenfeld G (2001) Chromatin goes global. Mol Cell 8: 263-268.

Blobe GC, Schiemann WP, and Lodish HF (2000) Role of transforming growth factor beta in human disease. N Engl J Med 342: 1350-1358.

Border WA and Noble NA (1997) TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int 51: 1388-1396.

Decker CJ and Parker R (1994) Mechanisms of mRNA degradation in eukaryotes. Trends Biochem Sci 19: 336-340.

Dervan PB (2001) Molecular recognition of DNA by small molecules. Bioorg Med Chem 9: 2215-2235.

Dickinson LA, Gulizia RJ, Trauger JW, Baird EE, Mosier DE, Gottesfeld JM, and Dervan PB (1998) Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc Natl Acad Sci USA 95: 12890-12895.

Fukuda N, Kubo A, Watanabe Y, Nakayama T, Soma M, Izumi Y, and Kanmatsuse K (1997) Antisense oligodeoxynucleotide complementary to platelet-derived growth factor A-chain messenger RNA inhibits the arterial proliferation in spontaneously hypertensive rats without altering their blood pressures. J Hypertens 15: 1123-1136.

Gottesfeld JM, Belitsky JM, Melander C, Dervan PB, and Luger K (2002) Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol 321: 249-263.

Gottesfeld JM, Melander C, Suto RK, Raviol H, Luger K, and Dervan PB (2001) Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides. J Mol Biol 309: 615-629.

Gottesfeld JM, Neely L, Trauger JW, Baird EE, and Dervan PB (1997) Regulation of gene expression by small molecules. Nature (Lond) 387: 202-205.

Grant MB, Wargovich TJ, Bush DM, Player DW, Caballero S, Foegh M, and Spoerri PE (1999) Expression of IGF-1, IGF-1 receptor and TGF-beta following balloon angioplasty in atherosclerotic and normal rabbit iliac arteries: an immunocytochemical study. Regul Pept 79: 47-53.

Joki N, Kaname S, Hirakata M, Hori Y, Yamaguchi T, Fujita T, Katoh T, and Kurokawa K (2000) Tyrosine-kinase dependent TGF-beta and extracellular matrix expression by mechanical stretch in vascular smooth muscle cells. Hypertens Res 23: 91-99.

Kim SJ, Glick A, Sporn MB, and Roberts AB (1989) Characterization of the promoter region of the human transforming growth factor-beta 1 gene. J Biol Chem 264: 402-408.

Kobayashi N, Nakano S, Mori Y, Kobayashi T, Tsubokou Y, and Matsuoka H (2001) Benidipine inhibits expression of ET-1 and TGF-beta1 in Dahl salt-sensitive hypertensive rats. Hypertens Res 24: 241-250.

Kopka ML, Yoon C, Goodsell D, Pjura P, and Dickerson RE (1985a) Binding of an antitumor drug to DNA, Netropsin and C-G-C-G-A-A-T-T-BrC-G-C-G. J Mol Biol 183: 553-563.

Kopka ML, Yoon C, Goodsell D, Pjura P, and Dickerson RE (1985b) The molecular origin of DNA-drug specificity in netropsin and distamycin. Proc Natl Acad Sci USA 82: 1376-1380.

Kotani M, Fukuda N, Ando H, Hu WY, Kunimoto S, Saito S, and Kanmatsuse K (2003) Chimeric DNA-RNA hammerhead ribozyme targeting PDGF A-chain mRNA specifically inhibits neointima formation in rat carotid artery after balloon injury. Cardiovasc Res 57: 265-276.

Kozak M (1992) Regulation of translation in eukaryotic systems. Annu Rev Cell Biol 8: 197-225.

Lown JW, Krowicki K, Bhat UG, Skorobogaty A, Ward B, and Dabrowiak JC (1986) Molecular recognition between oligopeptides and nucleic acids: novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity. Biochemistry 25: 7408-7416.

Lyons RM and Moses HL (1990) Transforming growth factors and the regulation of cell proliferation. Eur J Biochem 187: 467-473.

McKeown M (1992) Alternative mRNA splicing. Annu Rev Cell Biol 8: 133-155.

Mocharla H, Mocharla R, and Hodes ME (1990) Coupled reverse transcription-polymerase chain reaction (RT-PCR) as a sensitive and rapid method for isozyme genotyping. Gene 93: 271-275.

Romeo D, Allison RS, Kondaiah P, and Wakefield LM (1997) Recharacterization of the start sites for the major human transforming growth factor-beta 1 mRNA. Gene 189: 289-295.

Sambrook J, Fritsch EF, and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory (CSH), Cold Spring Harbor, NY.

Shinohara K, Narita A, Oyoshi T, Bando T, Teraoka H, and Sugiyama H (2004) Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides. J Am Chem Soc 126: 5113-5118.

Sporn MB and Roberts AB (1992) Transforming growth factor-beta: recent progress and new challenges. J Cell Biol 119: 1017-1021.

Trauger JW, Baird EE, and Dervan PB (1996) Recognition of DNA by designed ligands at subnanomolar concentrations. Nature (Lond) 382: 559-561.

White S, Baird EE, and Dervan PB (1997) On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem Biol 4: 569-578.

White S, Szewczyk JW, Turner JM, Baird EE, and Dervan PB (1998) Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature (Lond) 391: 468-471.