Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models

Cancer Cell - Tập 23 - Trang 121-128 - 2013
Ryan B. Corcoran1,2, Katherine A. Cheng3, Aaron N. Hata1,2, Anthony C. Faber1,4, Hiromichi Ebi1,2, Erin M. Coffee1,5, Patricia Greninger1, Ronald D. Brown1, Jason T. Godfrey1, Travis J. Cohoon3, Youngchul Song1, Eugene Lifshits1, Kenneth E. Hung5, Toshi Shioda1, Dora Dias-Santagata6, Anurag Singh7, Jeffrey Settleman8, Cyril H. Benes1, Mari Mino-Kenudson6, Kwok-Kin Wong3
1Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA
2Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
3Dana Farber Cancer Institute, Boston, MA 02114, USA
4Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA
5Division of Gastroenterology, Tufts Medical Center, Boston, MA 02111, USA
6Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA
7Boston University, Boston, MA 02118, USA
8Genentech Inc., South San Francisco, CA 94080, USA

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