Synthetic Chemical Trade as a Potential Driver of Global Health Disparities and Data Gaps on Synthetic Chemicals in Vulnerable Populations

Current Environmental Health Reports - Tập 7 - Trang 1-12 - 2020
Dina Goodman1, Nicholas Arisco1, Lindsay M. Jaacks1
1Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA

Tóm tắt

Most research on toxic exposures in vulnerable populations focuses on air pollution. Synthetic chemical production, however, is a multi-billion-dollar industry that lacks appropriate international regulation to protect those exposed to toxic chemicals. This paper aims to describe the country-level import and export of key groups of synthetic chemicals using data from the United Nations Comtrade Database and provide a narrative review of the evidence from January 2018 to August 2019 on exposure to, health effects of, and interventions to reduce synthetic chemicals in vulnerable populations around the world. Generally, a small number of high-income countries export the majority of synthetic chemicals, while most low-income countries import more chemicals than they export, which may contribute to higher levels of synthetic chemicals in those settings. However, few studies have quantified exposures to synthetic chemicals in low- and middle-income countries, the health effects of such exposures, or interventions to mitigate exposures. Synthetic chemicals continue to enter markets despite our limited knowledge of their effects on human health, particularly in the most vulnerable populations. We need more research to understand the health impacts of these pervasive exposures.

Tài liệu tham khảo

•• Landrigan PJ, Fuller R, Acosta NJ, Adeyi O, Arnold R, Baldé AB, et al. The Lancet Commission on pollution and health. Lancet. 2017; Seminal report on global distribution of pollution and burden of disease resulting from exposures. Yeh BJ, Lim WA. Synthetic biology: lessons from the history of synthetic organic chemistry. Nat Chem Biol. 2007;3:521–5. Jones AW. Early drug discovery and the rise of pharmaceutical chemistry. Drug Test Anal. 2011;3(6):337–44. Bernhardt ES, Rosi EJ, Gessner MO. Synthetic chemicals as agents of global change. Front Ecol Environ. 2017;15(2):84–90. Massey R, Jacobs M, Gallagher L, Dlugolecki A, Geiser K, Edwards S. Global chemicals outlook–towards sound management of chemicals. Nairobi: United Nations Environment Programme; 2013. Institute of Medicine, Roundtable on Environmental Health Sciences, Research, and Medicine, Board on Population Health and Public Health Practice. The challenge: chemicals in today’s society. In Identifying and Reducing Environmental Health Risks of Chemicals in Our Society: Workshop Summary 2014. Washington, DC: National Academies Press. •• Calafat AM, Valentin-Blasini L, Ye X. Trends in exposure to chemicals in personal care and consumer products. Curr Environ Health Rep. 2015;2(4):348–55 Review of synthetic chemical exposures (plasticizers and pesticides) focused on national biomonitoring in the USA, Germany, and Canada. Agency for Toxic Substances and Disease Registry. Chemical Classes Home Page. CDC. 2008. United Nations. Globally Harmonized System of Classification and Labelling of Chemicals (GHS). New York and Geneva: United Nations; 2009. Report No.: ST/SG/AC.10/30/Rev.3 •• Secretary-General of the United Nations General Assembly. Report of the Special Rapporteur on the implications for human rights of the environmentally sound management and disposal of hazardous substances and wastes. New York: United Nations; 2018. Report No.: A/73/567. Report with important implications for environmental justice as relates to synthetic chemical exposures in vulnerable populations around the world; a call to action for lawmakers and regulators. Balde CP, Forti V, Gray V, Kuehr R, Stegmann P. The Global E-waste Monitor 2017: Quantities, flows and resources: United Nations University, International Telecommunication Union, and International Solid Waste Association; 2017. Xanthos D, Walker TR. International policies to reduce plastic marine pollution from single-use plastics (plastic bags and microbeads): a review. Mar Pollut Bull. 2017;118(1):17–26. BBC. Plastic bag bans around the world. BBC; 2008. Hardin T. Rwanda plastic bag ban. Plastic Oceans. 2018. Kardish C. How Rwanda became the world’s unlikely leader in plastic bag bans. Governing. 2014. Clapp J, Swanston L. Doing away with plastic shopping bags: international patterns of norm emergence and policy implementation. Environ Polit. 2009;18(3):315–32. Kaberuka D. Rwanda Vision 2020. 2000. Chen A, Dietrich KN, Huo X, Ho S-m. Developmental neurotoxicants in E-waste: an emerging health concern. Environ Health Perspect 2011;119(4):431–438. Robinson BH. E-waste: an assessment of global production and environmental impacts. Sci Total Environ. 2009;408(2):183–91. Huo X, Peng L, Xu X, Zheng L, Qiu B, Qi Z, et al. Elevated blood Lead levels of children in Guiyu, an electronic waste recycling town in China. Environ Health Perspect. 2007;115(7):1113–7. Lundgren MK. The global impact of e-waste: Addressing the challenge. Report. 2012/12/20/. Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C, et al. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environ Health Perspect. 2013;121(2):257–62. Wu K, Xu X, Liu J, Guo Y, Li Y, Huo X. Polybrominated diphenyl ethers in umbilical cord blood and relevant factors in neonates from Guiyu, China. Environ Sci Technol. 2010;44(2):813–9. Li M, Huo X, Pan Y, Cai H, Dai Y, Xu X. Proteomic evaluation of human umbilical cord tissue exposed to polybrominated diphenyl ethers in an e-waste recycling area. Environ Int. 2018;111:362–71. Li H, Yu L, Sheng G, Fu J, Peng PA. Severe PCDD/F and PBDD/F pollution in air around an electronic waste dismantling area in China. Environ Sci Technol. 2007;41(16):5641–6. Zeng X, Xu X, Zheng X, Reponen T, Chen A, Huo X. Heavy metals in PM2.5 and in blood, and children's respiratory symptoms and asthma from an e-waste recycling area. Environ Pollut. 2016;210:346–53. Zheng X, Xu X, Yekeen TA, Zhang Y, Chen A, Kim S, et al. Ambient air heavy metals in PM 2.5 and potential human health risk assessment in an informal electronic-waste recycling site of China. Aerosol Air Qual Res. 2016;16:388–97. Deng WJ, Zheng JS, Bi XH, Fu JM, Wong MH. Distribution of PBDEs in air particles from an electronic waste recycling site compared with Guangzhou and Hong Kong, South China. Environ Int. 2007;33(8):1063–9. World Health Organization. Global action plan on antimicrobial resistance. 2015. Bergman Å, Heindel JJ, Jobling S, Kidd K, Zoeller TR, World Health Organization. State of the science of endocrine disrupting chemicals 2012: World Health Organization; 2013. European Parliament. Regulation (EC) No 1907/2006: Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Brussels: European Parliament; 2007. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32006R1907 Senate and House of Representatives of the United States of America in Congress. Public Law 114-182: Frank R. Lautenberg Chemical Safety for the 21st Century Act Washington, DC: Senate and House of Representatives of the United States of America in Congress; 2016. Available from: https://www.congress.gov/114/plaws/publ182/PLAW-114publ182.pdf. Schmidt CW. TSCA 2.0: a new era in chemical risk management. Environ Health Perspect. 2016;124(10):A182–a6. United Nations High Commissioner for Human Rights. Special Rapporteur on Toxic Wastes. Geneva: United Nations High Commissioner for Human Rights; 2017. Van Den Berg H, Manuweera G, Konradsen F. Global trends in the production and use of DDT for control of malaria and other vector-borne diseases. Malar J. 2017;16(1):401. Greenall M, Kunii O, Thomson K, Bangert R, Nathan O. Reaching vulnerable populations: lessons from the Global Fund to Fight AIDS, Tuberculosis and Malaria. Bull World Health Organ. 2017;95(2):159–61. Calafat AM, Wong LY, Kuklenyik Z, Reidy JA, Needham LL. Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environ Health Perspect. 2007;115(11):1596–602. Calafat AM. The U.S. National health and nutrition examination survey and human exposure to environmental chemicals. Special Issue: Berlin International Conference on Human Biomonitoring 2012;215(2):99–101. Centers for Disease Control and Prevention. Fourth National Report on Human Exposure to Environmental Chemicals. Updated Tables, January 2019, Volume Two. Atlanta: Centers for Disease Control and Prevention; 2019. Government of Canada Human Biomonitoring of Environmental Chemicals. 2010. European Commission LIFE programme. EASME - European Commission. 2018. National Center for Health Statistics NHANES 2015-2016 Overview. CDC. 2018. Statistics Canada Canadian health measures survey (CHMS) data user guide: cycle 1. 2011. Barnett-Itzhaki Z, Esteban López M, Puttaswamy N, Berman T. A review of human biomonitoring in selected Southeast Asian countries. Environ Int. 2018;116:156–64. Stuetz W, Prapamontol T, Erhardt J, Classen H. Organochlorine pesticide residues in human milk of a Hmong hill tribe living in Northern Thailand. Sci Total Environ. 2001;273(1–3):53–60. Sudaryanto A, Kajiwara N, Takahashi S, Tanabe S. Geographical distribution and accumulation features of PBDEs in human breast milk from Indonesia. Environ Pollut. 2008;151(1):130–8. Zamir R, Athanasiadou M, Nahar N, Mamun M, Mosihuzzaman M, Bergman Å. Persistent organohalogen contaminants in plasma from groups of humans with different occupations in Bangladesh. Chemosphere. 2009;74(3):453–9. Basu N, Horvat M, Evers DC, Zastenskaya I, Weihe P, Tempowski J. A state-of-the-science review of mercury biomarkers in human populations worldwide between 2000 and 2018. Environ Health Perspect. 2018;126(10):106001. Kordas K, Ravenscroft J, Cao Y, McLean EV. Lead exposure in low and middle-income countries: perspectives and lessons on patterns, injustices, economics, and politics. Int J Environ Res Public Health. 2018;15(11). Zhang T, Bai X-Y, Lu S-Y, Zhang B, Xie L, Zheng H-C, et al. Urinary metabolites of organophosphate flame retardants in China: health risk from tris(2-chloroethyl) phosphate (TCEP) exposure. Environ Int. 2018;121:1363–71. Li AJ, Kannan K. Urinary concentrations and profiles of organophosphate and pyrethroid pesticide metabolites and phenoxyacid herbicides in populations in eight countries. Environ Int. 2018;121:1148–54. Bertoncello Souza M, Passoni MT, Palmke C, Meyer KB, Venturelli AC, Araujo G, et al. Unexpected, ubiquitous exposure of pregnant Brazilian women to diisopentyl phthalate, one of the most potent antiandrogenic phthalates. Environ Int. 2018;119:447–54. Wang H, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970, 2013, 2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1084–150. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharm Ther. 2015;40(4):277–83. Arcand-Hoy L, Nimrod A, Benson W. Endocrine-modulating substances in the environment: estrogenic effects of pharmaceutical products. Int J Toxicol. 1998;17(2):139–58. Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742–50. Basu S, Yudkin JS, Kehlenbrink S, Davies JI, Wild SH, Lipska KJ, et al. Estimation of global insulin use for type 2 diabetes, 2018-30: a microsimulation analysis. Lancet Diabetes Endocrinol. 2019;7(1):25–33. Petitti DB. Combination estrogen–progestin oral contraceptives. N Engl J Med. 2003;349(15):1443–50. Kim K-H, Kabir E, Jahan SA. Exposure to pesticides and the associated human health effects. Sci Total Environ. 2017;575:525–35. Baia-da-Silva DC, Brito-Sousa JD, Rodovalho SR, Peterka C, Moresco G, Lapouble OMM, et al. Current vector control challenges in the fight against malaria in Brazil. Rev Soc Bras Med Trop. 2019;52:e20180542. Kang SY, Battle KE, Gibson HS, Ratsimbasoa A, Randrianarivelojosia M, Ramboarina S, et al. Spatio-temporal mapping of Madagascar’s malaria indicator survey results to assess plasmodium falciparum endemicity trends between 2011 and 2016. BMC Med. 2018;16(1):71. National Malaria Control Programme of Madagascar National strategic plan for malaria control in Madagascar 2013–2017: consolidating the gains with a view to elimination of malaria from Madagascar, 2015–2017 revision. 2015. Clarke JS. Brazil pesticide approvals soar as Jair Bolsonaro moves to weaken rules. Unearthed. 2019. Phillips D. Hundreds of new pesticides approved in Brazil under Bolsonaro. The Guardian. 2019. Gourmelon G. Global plastic production rises, recycling lags. World Watch Institute; 2015. Report no. 2015/01/27/. European Commission Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Off J Eur Union. 2006;396:1–849. Patel M, von Thienen N, Jochem E, Worrell E. Recycling of plastics in Germany. Resour Conserv Recycl. 2000;29(1):65–90. Betts KS. Perfluoroalkyl acids: what is the evidence telling us? National Institute of Environmental Health Sciences; 2007. Dallaire R, Dewailly É, Pereg D, Dery S, Ayotte P. Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environ Health Perspect. 2009;117(9):1380–6. Hoffman K, Vieira V, Webster T, White R, editors. Exposure to polyfluoroalkyl chemicals and attention deficit hyperactivity disorder in US children aged 12–15 years. Abstracts: ISEE 21st Annual Conference, Dublin, Ireland; 2009. Collignon P, Beggs JJ, Walsh TR, Gandra S, Laxminarayan R. Anthropological and socioeconomic factors contributing to global antimicrobial resistance: a univariate and multivariable analysis. Lancet Planet Health. 2018;2(9):e398–405. Stanaway JD, Afshin A, Gakidou E, Lim SS, Abate D, Abate KH, et al. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990, 2013, 2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1923–94. Feigin VL, Abajobir AA, Abate KH, Abd-Allah F, Abdulle AM, Abera SF, et al. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol. 2017;16(11):877–97. National Institute of Environmental Health Sciences. 2018–2023 Strategic plan: advancing environmental health sciences, improving health. Durham: U.S. Department of Health and Human Services, National Institutes of Health; 2018. Contract No.: 18-ES-7935 Ceballos DM, Broadwater K, Page E, Croteau G, La Guardia MJ. Occupational exposure to polybrominated diphenyl ethers (PBDEs) and other flame retardant foam additives at gymnastics studios: before, during and after the replacement of pit foam with PBDE-free foams. Environ Int. 2018;116:1–9. Lee I, Kim S, Kim K-T, Kim S, Park S, Lee H, et al. Bisphenol A exposure through receipt handling and its association with insulin resistance among female cashiers. Environ Int. 2018;117:268–75. Giovanoulis G, Nguyen MA, Arwidsson M, Langer S, Vestergren R, Lagerqvist A. Reduction of hazardous chemicals in Swedish preschool dust through article substitution actions. Environ Int. 2019;130:104921. Dembsey NA, Brokaw FM, Stapleton HM, Dodson RE, Onasch J, Jazan E, et al. Intervention to reduce gymnast exposure to flame retardants from pit foam: a case study. Environ Int. 2019;127:868–75. World Bank. Classifying countries by income. New York: World Bank; 2018. Available from: https://datatopics.worldbank.org/world-development-indicators/stories/the-classification-of-countries-by-income.html Fann N, Kim S-Y, Olives C, Sheppard L. Estimated changes in life expectancy and adult mortality resulting from declining PM 2.5 exposures in the contiguous United States: 1980–2010. Environ Health Perspect. 2017;125(9):097003. Zhang Y, West JJ, Mathur R, Xing J, Hogrefe C, Roselle SJ, et al. Long-term trends in the PM2. 5-and O3-related mortality burdens in the United States under emission reductions from 1990 to 2010. Atmos Chem Phys Discuss. 2018:1–25. Global Burden of Disease Study Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1151–1210. Colbourne JK, Pfrender ME, Gilbert D, Thomas WK, Tucker A, Oakley TH, et al. The Ecoresponsive genome of Daphnia pulex. Science. 2011;331(6017):555–61.