Synthesis of alpha amylase inhibitors based on privileged indole scaffold

Ramasubbu, 1996, Structure of human salivary α-amylase at 1.6Å resolution: implications for its role in the oral cavity, Acta Crystallogr. Sect. D, 52, 435, 10.1107/S0907444995014119

2000, 65

Liang, 1999, J. Chromatogr. Biol. Med. Appl., 724

Gupta, 2003, Microbial-amylases: biotechnological perspective, Process Biochem., 00, 1

Rana, 2013, A-amylases from microbial sources and its potential applications in various Industries, Natl. Acad. Sci. Lett., 36, 9, 10.1007/s40009-012-0104-0

Mobini-dehkordi, 2012, Application of α-amylase in biotechnology, J. Biol. Today’s World, 1, 39

Quax, 2006, Prokaryotes, 777, 10.1007/0-387-30741-9_22

Channale, 2016, Characterization of two coleopteran a-amylases and molecular insights into their differential inhibition by synthetic a-amylase inhibitor, acarbose, Insect Biochem. Mol. Biol., 74, e11

Ibrahim, 2017, 8-Hydroxyirilone 5-methyl ether and 8-hydroxyirilone, new antioxidant and α-amylase inhibitors isoflavonoids from Iris germanica rhizomes, Bioorg. Chem., 70, 192, 10.1016/j.bioorg.2016.12.010

Ibrahim, 2017, Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes, Revista Brasileira de Farmacognosia, 27, 170, 10.1016/j.bjp.2016.10.001

Kato, 2016, Synthesis and study of the pancreatic α-amylase inhibitory activity of methyl acarviosin and its derivatives, Tetrahedron Lett., 57, 1365, 10.1016/j.tetlet.2016.02.053

Oboh, 2016, Influence of gallic acid on α-amylase and α-glucosidase inhibitory properties of acarbose, J. Food Drug Anal., 24, 627, 10.1016/j.jfda.2016.03.003

Schnell, 2016, Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, noninterventional, observational study data pool, J. Diabet. Complications, 30, 628, 10.1016/j.jdiacomp.2016.01.023

Denhart, 2009, Bioorg. Med. Chem. Lett., 19, 4031, 10.1016/j.bmcl.2009.06.026

Imran, 2015, Curr. Med. Chem., 22, 4412, 10.2174/0929867322666151006093930

Shaveta, 2014, Eur. J. Med. Chem., 74, 440, 10.1016/j.ejmech.2013.12.047

Sharma, 2012, Eur. J. Med. Chem., 48, 16, 10.1016/j.ejmech.2011.11.028

Imran, 2014, Molecules, 19, 11722, 10.3390/molecules190811722

Mehndiratta, 2014, Eur. J. Med. Chem., 85, 468, 10.1016/j.ejmech.2014.08.020

Liew, 2014, Tetrahedron, 70, 4910, 10.1016/j.tet.2014.05.068

Yamuna, 2012, Eur. J. Med. Chem., 47, 228, 10.1016/j.ejmech.2011.10.046

Soon, 2015, Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae), Fitoterapia, 102, 182, 10.1016/j.fitote.2015.01.019

Zhang, 1998, Inhibition of salivary amylase by black and green teas and their effects on the intraoral hydrolysis of starch, Caries Res., 32, 233, 10.1159/000016458

Samira, 2016, Indole-3-acetic acid (IAA) producing Pseudomonas isolates inhibit seed germination and α-amylase activity in durum wheat (Triticum turgidum L.), Span. J. Agric. Res., 14, e0802, 10.5424/sjar/2016141-8859

Jamil, 2016, Α-amylase modulation: discovery of inhibitors using a multi-pharmacophore approach for virtual screening, Chem. Med. Chem., 11, 2372, 10.1002/cmdc.201600427

Fazal Rahim, Muhammad Ali, Shifa Ullah, Umer Rashid, Hayat Ullah, Muhammad Taha, Muhammad Tariq Javed, Wajid Rehman, Aftab Ahmad Khan, Obaid Ur Rahman Abid, Muhammad Bilal, Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies (2016). http://dx.doi.org/10.1016/j.cclet.2015.12.035.

Rashid, 2016, Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: in vitro urease inhibition and molecular docking, Studies, 66, 111

Taha, 2016, Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs, Bioorg. Chem., 68, 56, 10.1016/j.bioorg.2016.07.008

Taha, 2016, Synthesis of novel disulfide and sulfone hybrid scaffolds as potent β-glucuronidase inhibitor, Bioorg. Chem., 68, 15, 10.1016/j.bioorg.2016.07.002

Taha, 2016, Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors, Bioorg. Med. Chem., 24, 3696, 10.1016/j.bmc.2016.06.008

Rahim, 2015, Triazinoindole analogs as potent inhibitors of α-glucosidase: synthesis, biological evaluation and molecular docking studies, Bioorg. Chem., 58, 81, 10.1016/j.bioorg.2014.12.001

Rahim, 2015, Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase, Bioorg. Chem., 62, 15, 10.1016/j.bioorg.2015.06.006

Rahim, 2015, Isatin based Schiff bases as inhibitors of α-glucosidase: synthesis, characterization, in vitro evaluation and molecular docking studies, Bioorg. Chem., 60, 42, 10.1016/j.bioorg.2015.03.005

Rahim, 2015, Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents, Bioorg. Chem., 63, 123, 10.1016/j.bioorg.2015.10.005

Taha, 2016, Novel thiosemicarbazide–oxadiazole hybrids as unprecedented inhibitors of yeast α-glucosidase and in silico binding analysis, RSC Adv., 6, 33733, 10.1039/C5RA28012E

Zhang, 2011, Grape skin extract inhibits mammalian intestinal α-glucosidase activity and suppresses postprandial glycemic response in streptozocin-treated mice, Food Chem., 126, 466, 10.1016/j.foodchem.2010.11.016

Yuqing, 2017, Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera, Food Chem., 214, 259, 10.1016/j.foodchem.2016.06.100

Williams, 2015, The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif, Nat. Chem. Biol., 11, 691, 10.1038/nchembio.1865

Schrodinger Release 2016-1: Maestro, version 10.1, Schrodinger, LLC, New York, 2015.