Synthesis of Some New Benzylic Ethers from 1,8-Cineole with Antimicrobial Activity

Armando J. D. Silvestre1, José A. S. Cavaleiro1, Sónia S. Feio2, José C. Roseiro2, Bernard Delmond3, Claude Filliatre3
1 Department of Chemistry, University of Aveiro, P-3810 Aveiro, Portugal, PT
2 Instituto Nacional de Engenharia e Tecnologia Industrial, IBQTA, Laboratório de Microbiologia Industrial, P-1699 Lisboa Codex, Portugal, PT
3 Institut du Pin, Université de Bordeaux I, F-33405 Talence, France, FR

Tóm tắt

 The synthesis and structural characterization of several benzylic derivatives of 3-exo-hydroxy-1,8-cineole is described. The new compounds show antimicrobial activity against Cladosporium cucumerinum, Staphylococcus aureus, Mycobacterium smegmatis, Pseudomonas aeruginosa, and Candida albicans.