Alok Pandey1, R. Rajavel1, Sandeep Chandraker2, Deepak Dash2
1Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52 Tamilnandu, India
2Royal College of Pharmacy Science Raipur, (C.G.) 492101, India
Tóm tắt
Schiff Bases of 2‐amino‐5‐aryl‐1,3,4‐thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4‐thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against swiss albino mice, anti‐inflammatory activity against Wister albino rats. The compounds showed significant antibacterial activity against Staphylococcus aureus (gram‐positive) bacteria and E. coli (gram‐negative) bacteria.
