Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity

Journal of Chemistry - Tập 2015 - Trang 1-5 - 2015
Satish Balasaheb Nimse1, Dilipkumar Pal2, Avijit Mazumder3, Rupa Mazumder3
1Institute for Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 24252, Republic of Korea
2Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495009, India
3Department of Pharmaceutical Technology, Noida Institute of Engineering and Technology, Greater Noida 201306, India

Tóm tắt

The amide derivatives of cinnamic acid were synthesized and their antimicrobial and antioxidant activities were investigated. The investigation of antimicrobial potentials of the compounds demonstrated a strong activity against 21 bacterial strains comprising Gram-positive and Gram-negative bacteria. Compounds2a,2b, and3bshowed strong antimicrobial activity against all microorganisms with the pMIC value ranging from 2.45 to 3.68. Compounds2a,3a, and3bdemonstrated strong antioxidant activity with % inhibition of the DPPH radical of 51% (±1.14), 41% (±1.01), and 50% (±1.23), respectively. These findings indicate that the amide derivatives of the cinnamic acid possess strong antibacterial and antioxidant activities.

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Journal of Chemistry

Tập 2015

1-5

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