Synthesis, molecular docking and antiviral screening of novel N′-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazides

Sana Aslam1,2, Matloob Ahmad3, Muhammad Athar2, Usman Ali Ashfaq4, John M. Gardiner5, Catherine Montero6, Mervi Detorio6, Masood Parvez7, Raymond F. Schinazi6
1Department of Chemistry, Government College Women University Faisalabad, Pakistan
2Institute of Chemistry, University of the Punjab, Lahore, Pakistan
3Department of Chemistry, Government College University, Faisalabad, Pakistan
4Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan
5School of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester, UK
6Laboratory of Biochemical Pharmacology, Emory University School of Medicine/Veterans Affairs Medical Center, Atlanta, USA
7Department of Chemistry, The University of Calgary, Calgary, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Ahmad M, Siddiqui HL, Ahmad SM, Parvez M, Tizzard GJ (2010a) Synthesis and crystal structures of a series of pyrazolo[4,3-c][1,2]benzothiazine,2,4-dihydro-3,4-dimethyl-,5,5-dioxide derivatives. J Chem Crystallogr 40:1188–1194

Ahmad M, Siddiqui HL, Azam M, Bukhari IH, Parvez M (2010b) 2-(2-Oxo-2-phenylethyl)-1,2-benzisothiazol-3(2H)-one-1,1-dioxide. Acta Cryst E 66:o616

Ahmad M, Siddiqui HL, Rizvi UF, Ahmad S, Parvez M (2010c) 3-Benzoyl-4-hydroxy-2H-1,2-benzothiazine-1,1-dioxide. Acta Cryst E 66:o862

Ahmad M, Siddiqui HL, Zia-ur-Rehman M, Parvez M (2010d) Antioxidant and antibacterial activities of novel N′-arylmethylidene-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2] benzothiazin-2-(4H)-yl) acetohydrazides. Eur J Med Chem 45:698–704

Ahmad M, Rizvi SUF, Siddiqui HL, Ahmad S, Parvez M, Suliman R (2012) Antioxidant and antimicrobial studies of novel N-(substituted-2-chloroquinolin-3-yl)methylidene-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazides-1,1-dioxides. Med Chem Res 21(9):2340–2348

Ahmad M, Siddiqui HL, Gardiner JM, Parvez M, Aslam S (2013a) Synthesis and antioxidant studies of novel N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides. Med Chem Res 22:794–805

Ahmad M, Aslam S, Bukhari MH, Montero C, Detorio M, Parvez M, Schinazi RF (2013b) Synthesis of novel pyrazolobenzothiazine 5,5-dioxide derivatives as potent anti-HIV-1 agents. Med Chem Res. doi: 10.1007/s00044-013-0718-x

Altomare A, Cascarano M, Giacovazzo C, Guagliardi A (1993) SIR92. J Appl Cryst 26:343

Aslam S, Ahmad M, Zia-ur-Rehman M, Montero C, Detorio M, Parvez M, Schinazi RF (2013) Synthesis and anti-HIV-1 screening of novel N′-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides. Arch Pharm Res. doi: 10.1007/s12272-013-0200-9

Barrd-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blein C, Vdzinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation ofa T-lymphotrophic retro-virus from a patient at risk for Acquired Immune Deficiency Syndrome (AIDS). Science 220:868–871

Barreca ML, Manfroni G, Leyssen P, Winquist J, Kaushik-Basu N, Paeshuyse J, Krishnan R, Iraci N, Sabatini S, Tabarrini O, Basu A, Danielson UH, Neyts J, Cecchetti V (2013) Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication. J Med Chem 56:2270–2282

Belen’kii MS, Schinazi RF (1994) Multiple drug effect analysis with confidence interval. Antiviral Res 25:1–11

Beurskens PT, Admiraal G, Beurskens G, Bosman WP, de Gelder R, Israel R, Smits JMM (1994) The DIRDIF-94 program system technical report of the crystallography laboratory. University of Nijmegen, Nijmegen

Broder S, Gallo RC (1984) A pathogenic retrovirus (HTLV-III) linked to AIDS. N Engl J Med 311(20):1292–1297

Bukhari MH, Siddiqui HL, Ahmad M, Hussain T, Moloney MG (2011) Synthesis and anti-bacterial activities of some novel pyrazolobenzothiazine-based chalcones and their pyrimidine derivatives. Med Chem Res 21(10):2885–2895

Caruso I, Montrone F, Boari L (1994) Lornoxicam versus diclofenac in rheumatoid arthritis: a double-blind, multicenter study. Adv Ther 11:132–138

Constantine JW (1967) Aggregation and adhesion of rat platelets. Nature 214:1084–1086

Engelhardt G, Homma D, Schlegel K et al (1995) Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new nonsteroidal anti-inflammatory agent with favourable gastrointestinal tolerance. Inflamm Res 44:422–433

Farrugia LJ (1997) J Appl Cryst 30:565

Feriono PM, Jaffe HW, Palmer E, Peterman TA, Francis DP, Kalyanaraman VS, Weinstein RA, Stoneburner RL, Alexander WJ, Raevsky C, Gethchell JP, Warfield D, Haverkos HW, Kilbourne BW, Nicholson JKA, Curran JW (1985) Transfusion-associated acquired immunodeficiency syndrome: evidence for persistent infection in blood donors. N Engl J Med 312:1293–1296

Francis DP, Curran JW, Essex M (1983) Epidemic acquired immune deficiency syndrome: epidemiologic evidence for a transmissible agent. J Natl Cancer Inst 71(1):1–4

Giuseppe M, Arnaldo F, Patrizia T (1987) Derivatives of pyridobenzothiazine with high anti-microbial activity. US Patent 4,668,784, 26 May 1987

Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A (1981) Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med 305(24):1425–1431

Hooft R (1998) Collect. Nonius B V, Delft

Ikeda T, Kakegawa H, Miyataka H, Matsumoto H, Satoht T (1992) Anti-allergic and anti-inflammatory actions of 20-(tetrazole-5-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxanilide-1,1-dioxide. Biorg Med Chem Lett 2:709–714

Klatzman D, Barrd-Sinoussi F, Nugeyre MT, Dauguet C, Vilmer E, Griscelli C, Brun-Vdzinet F, Rouzioux C, Gluckman JC, Chermann JC, Montagnier L (1984) Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T-lymphocytes. Science 225:59–63

Krapcho J (1973) Benzothiazine derivatives. 3,725,403, 3 Apr 1973

Krapcho J, Turk CF (1975) 1-Substituted-4-phenyl-4H-[1,2,4]triazolo[3,4-c][1,4] benzothiazines or benzoxazines. US Patent 3,929,783, 30 Dec 1975

Lomabardino JG, Wiseman EH, McLamore WM (1971) Synthesis and antiinflammatory activity of some 3-carboxamides of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine-1,1-dioxide. J Med Chem 14:1171–1175

Lombardino JG, Wiseman EH, Chiaini J (1973) Potent antiinflammatory N-heterocyclic 3-carboxamides of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide. J Med Chem 16:493–496

Marfat A (1985) Anti-inflammatory 2-methyl-2H-1,2-benzo-(o-thieno-)thiazine-3-carboxamide-1,1-dioxide derivatives, compositions, and method of use therefor.US Patent 4,551,452, 5 Nov 1985

Masur H, Michelis MA, Greene JB, Onorato I, Vande Stouwe RA, Holzman RS, Wormser G, Brettman L, Lange M, Murray HW, Cunningham-Rundles S (1981) An outbreak of community-acquired pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N Engl J Med 305(24):1431–1438

McCormick JB, Getchell JP, Mitchell SW, Hicks DR (1984) Ribavirin suppresses replication of lymphadenopathy-associated virus in cultures of human adult T lymphocytes. Lancet 2(8416):1367–1369

Myung PS, Soon KK (2000) Dehydration of alcohols; synthesis of 3-alkoxy-3-methylcarboxyl-4-oxo-1,2-benzothiazine derivatives. Bull Korean Chem Soc 21(12):1249–1250

Otwinowski Z, Minor W (1997) Methods Enzymol 276:307–326

Rosenbaum W, Dormont D, Spire B, Vilmer E, Gentilini M, Griscelli C, Montagnier L, Barre-Sinoussi F, Chermann JC (1985) Antimoniotungstate (HPA 23) treatment of three patients with AIDS and one with prodrome. Lancet 1(8426):450–451

Sandstrom EG, Kaplan JC, Byington RE, Hirsch MS (1985) Inhibition of human T-cell lymphotropic virus type III in vitro by phosphonoformate. Lancet 1(8444):1480–1482

Schinazi RF, Sommadossi PJ, Cannon DL, Xie MY, Hart GC, Smith JA, Hahan EF (1990) Activities of 3′-azido-3′-deoxythymidine nucleotide dimers in primary lymphocytes infected with human Immunodeficiency virus type 1. Antimicrob Agents Chemother 34:1061–1067

Shaw GM, Harper ME, Hahn BH, Epstein LG, Gajdusek DC, Price RW, Navia BA, Petito CK, O’Hara CJ, Groopman JE, Cho ES, Oleske JM, Wong Staal F, Gallo RC (1985) HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science 227(4683):177–182

Sheldrick GM (2008) A short history of SHELX. Acta Cryst A64:112–122

Siegal FP, Lopez C, Hammer GS, Brown AE, Kornfeld SJ, Gold J, Hassett J, Hirschman SZ, Siegal M, Cunningham-Rundles S, Adelsberg BR (1981) Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 305(24):1439–1444

Soler JE (1986) Derivatives of oxazinobenzothiazine-6,6-dioxide US Patent 4,563,452, 7 Jan 1986

Stuyver LJ, Lostia S, Adams M, Mathew SJ, Pai SB, Grier J, Tharnish MP, Choi Y, Chong Y, Choo H, Chu KC, Otto JM, Schinazi FR (2002) Antiviral activities and cellular toxicities of modified 2′,3′-dideoxy-2′,3′-didehydrocytidine analogues. Antimicrob Agents Chemother 46:3854–3860

Suh JJ, Hong YH, Kim BC (1987) Synthesis and antiinflammatory activity of 4-substituted-1,2-benzothiazine-3-carboxamide-1,1-dioxides. J Kor Pharm Sci 17(2):61–65

Turck D, Busch U, Heinzel G, Narjes H, Nehmiz G (1995) Effect of food on the pharmacokinetics of meloxicam after oral administration. Clin Drug Invest 9:270–276