Tổng hợp, phân tích và đánh giá dược lý của các dẫn xuất thiourea
Tóm tắt
Các hợp chất thiourea và dẫn xuất của chúng là các hợp chất có chứa lưu huỳnh hữu cơ với nhiều ứng dụng trong các lĩnh vực như tổng hợp hữu cơ và ngành công nghiệp dược phẩm. Các dẫn xuất thiourea đối xứng đã được tổng hợp qua phản ứng của nhiều loại anilin với CS2. Các hợp chất được tổng hợp đã được đặc trưng bằng các kỹ thuật quang phổ UV-visible và cộng hưởng từ hạt nhân (NMR). Các hợp chất này đã được sàng lọc để kiểm tra khả năng ức chế
Từ khóa
Tài liệu tham khảo
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2017, Biochemical, hematological and pathological effects of bispyribac sodium in female albino rats, J Vet Sci Technol, 8, 467
2016, Investigation of repressive and enhancive effects of fruit extracts on the activity of glucose-6-phosphatase, Pak J Pharm Sci, 29, 1985
2020, Enhancement of bioavailability and hepatoprotection by Silibinin through conversion to nanoparticles prepared by liquid antisolvent method, Arab J Chem, 13, 3682, 10.1016/j.arabjc.2020.01.002
2013, Biological activities of some Pyrazoline derivatives, Int J Pharm Bio Sci, 4, 727
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2018, Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach, BMC Compl Alt Med, 18, 332, 10.1186/s12906-018-2381-8
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1997, Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase, J Med Chem, 40, 137, 10.1021/jm9607360
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2012, Synthesis and evaluation of some novel 2,4-thiazolidinedione derivatives for antibacterial, antitubercular and antidiabetic activities
2018, Isolation of quercetin and mandelic acid from Aesculus indica fruit and their biological activities, BMC Biochem, 19, 5, 10.1186/s12858-018-0095-7
1982, Thiourea, a convenient reagent for the reductive cleavage of olefin ozonolysis products, Tetrahedron, 38, 3013, 10.1016/0040-4020(82)80187-7
2013, Thiourea and guanidine derivatives as antimalarial and antimicrobial agents, Curr Top Med Chem, 13, 2011, 10.2174/15680266113139990126
1925, The colorimetric determination of phosphorus, J Biol Chem, 66, 375, 10.1016/S0021-9258(18)84756-1
2016, Hematological markers of in vivo toxicity, J Hematol Thrombo Dis, 4, 236
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1997, Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase, J Med Chem, 40, 137, 10.1021/jm9607360
2019, Enzyme inhibitory, antioxidant and antibacterial potentials of synthetic symmetrical and unsymmetrical thioureas, Drug Des Dev Ther, 13, 3485, 10.2147/DDDT.S225311
2005, Histopathological and hematological effects of dimethoate 40EC on some organs of albino mice, J King Saud Univ, 18, 73
1998, Chlorogenic acid analogue S 3483: a potent competitive inhibitor of the hepatic and renal glucose-6-phosphatase systems, Arch Biochem Biophys, 351, 279, 10.1006/abbi.1997.0563
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2014, Synthesis of some nitrogen heterocycles and in vitro evaluation of their antimicrobial and antitumor activity, Res Chem Interm, 40, 537, 10.1007/s11164-012-0981-3
1974, A facile one-step synthesis of cis-2-cyclopentene- and cis-2-cyclohexene-1,4-diols from the corresponding cyclodienes, Synthesis, 1974, 876, 10.1055/s-1974-23462
1998, Chlorogenic acid analogue S 3483: a potent competitive inhibitor of the hepatic and renal glucose-6-phosphatase systems, Arch Biochem Biophys, 351, 279, 10.1006/abbi.1997.0563
2013, A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling, RSC Adv, 3, 16940, 10.1039/c3ra43252a
2013, Biological activities of some Pyrazoline derivatives, Int J Pharm Bio Sci, 4, 727
2020, Enhancement of bioavailability and hepatoprotection by Silibinin through conversion to nanoparticles prepared by liquid antisolvent method, Arab J Chem, 13, 3682, 10.1016/j.arabjc.2020.01.002
2003, Metal-free organocatalysis through explicit hydrogen bonding interactions, Chem Soc Rev, 32, 289, 10.1039/b107298f
2018, Isolation and identification of phenolic antioxidants from Pistacia integerrima gall and their anticholine esterase activities, Heliyon, 4, e01007, 10.1016/j.heliyon.2018.e01007
2018, Isolation of quercetin and mandelic acid from Aesculus indica fruit and their biological activities, BMC Biochem, 19, 5, 10.1186/s12858-018-0095-7
1980, Effect of two inhibitors of anion transport on the hydrolysis of glucose 6-phosphate by rat liver microsomes. Covalent modification of the glucose 6-P transport component, J Biol Chem, 255, 1113, 10.1016/S0021-9258(19)86149-5
2011, Synthesis and antibacterial and antifungal activities of thiourea derivatives of the alkaloid anabasine, Pharm Chem J, 45, 15, 10.1007/s11094-011-0551-9
2013, Thiourea and guanidine derivatives as antimalarial and antimicrobial agents, Curr Top Med Chem, 13, 2011, 10.2174/15680266113139990126
2013, Nomenclature of organic chemistry: IUPAC recommendations and preferred names 2013
2018, Isolation and identification of phenolic antioxidants from Pistacia integerrima gall and their anticholine esterase activities, Heliyon, 4, e01007, 10.1016/j.heliyon.2018.e01007
2017, A novel assay to determine acetylcholinesterase activity: the application potential for screening of drugs against Alzheimer’s disease, Biomed Chromatogr, 31, e3971, 10.1002/bmc.3971
1974, A facile one-step synthesis of cis-2-cyclopentene- and cis-2-cyclohexene-1,4-diols from the corresponding cyclodienes, Synthesis, 1974, 876, 10.1055/s-1974-23462
2013, A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling, RSC Adv, 3, 16940, 10.1039/c3ra43252a
2000; Jun 15, Thiourea and thiourea derivatives, Ullmann’s Encyclo Ind Chem, 1
2000; Jun 15, Thiourea and thiourea derivatives, Ullmann’s Encyclo Ind Chem, 1
2003, Metal-free organocatalysis through explicit hydrogen bonding interactions, Chem Soc Rev, 32, 289, 10.1039/b107298f
2014, Synthesis of some nitrogen heterocycles and in vitro evaluation of their antimicrobial and antitumor activity, Res Chem Interm, 40, 537, 10.1007/s11164-012-0981-3
2016, Hematological markers of in vivo toxicity, J Hematol Thrombo Dis, 4, 236
2019, Enzyme inhibitory, antioxidant and antibacterial potentials of synthetic symmetrical and unsymmetrical thioureas, Drug Des Dev Ther, 13, 3485, 10.2147/DDDT.S225311
2016, Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines, Eur J Med Chem, 113, 134, 10.1016/j.ejmech.2016.02.042
2011, Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis, Diabetes, 60, 3110, 10.2337/db11-0061
2012, A facile and efficient procedure for the synthesis of new benzimidazole-2-thione derivatives, Molecules, 17, 8578, 10.3390/molecules17078578
2017, Biochemical, hematological and pathological effects of bispyribac sodium in female albino rats, J Vet Sci Technol, 8, 467