Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors

European Journal of Medicinal Chemistry - Tập 139 - Trang 1-11 - 2017
María Carmen Costas-Lago1, Pedro Besada1, Fernanda Rodríguez-Enríquez2, Dolores Viña2, Santiago Vilar3, Eugenio Uriarte3,4, Fernanda Borges5, Carmen Terán1
1Departamento de Química Orgánica and Instituto de Investigación Sanitaria Galicia Sur (IISGS), Universidade de Vigo, 36310 Vigo, Spain
2Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS) Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
3Departamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain
4Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, 7500912 Santiago, Chile
5CIQUP/Departamento de Química e Bioquímica, Faculdade de Ciencias, Universidade do Porto, 4169-007 Porto, Portugal

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