Synthesis and in vitro study of [1,3,4]thiadiazol-2yl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles as antimicrobial agents

Diana, 2007, 3,5-Bis(3′-indolyl) pyrazoles, analogues of marine alkaloid nortopsentin: synthesis and antitumor properties, Bioorg. Med. Chem. Lett., 17, 6134, 10.1016/j.bmcl.2007.09.042 Farag, 2008, Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives, Bioorg. Med. Chem., 16, 881, 10.1016/j.bmc.2007.10.015 Faroumadi, 2005, Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl) piperazinyl quinolone derivatives, Bioorg. Med. Chem. Lett., 15, 4488, 10.1016/j.bmcl.2005.07.016 Faroumadi, 2005, Synthesis and in-vitro leishmanicidal activity of 2-(1-methyl-5-nitro-1H-imidazol-2-yl)-5-substituted-1,3,4-thiadiazole derivatives, Eur. J. Med., 40, 1346, 10.1016/j.ejmech.2005.07.002 Foroumadi, 2002, Antituberculosis agents. V. Synthesis, evaluation of in-vitro antituberculosis activity and cytotoxicity of some 2-(5-nitro-2-furyl)-1,3,4-thiadiazole derivatives, IL Farmaco., 57, 765, 10.1016/S0014-827X(02)01277-6 Genin, 2000, Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: Lead identification and SAR of 3-and 4-substituted derivatives, J. Med. Chem., 43, 1034, 10.1021/jm990383f Kadi, 2007, Synthesis, antimicrobial, anti-inflammatory activities of novel 2-(1-adamantyl)-5- substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles, Eur. J. Med. Chem., 42, 235, 10.1016/j.ejmech.2006.10.003 Kane, 2003, Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria, Bioorg. Med. Chem. Lett., 13, 4463, 10.1016/j.bmcl.2003.09.013 Kucukgezel, 2000, Synthesis, characterization and pharmacological properties of some 4-arylhydrazono-2-pyrazoline-5- one derivatives obtained from heterocyclic amines, Eur. J. Med. Chem., 3, 761, 10.1016/S0223-5234(00)90179-X Kuettel, 2007, Synthesis and evaluation of anti-parasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazole-3-yl]morpholine derivatives, J. Med. Chem., 50, 5833, 10.1021/jm700938n Liaras, 2011, Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation, Bioorg. Med. Chem., 19, 3135, 10.1016/j.bmc.2011.04.007 Matysiak, 2007, Evaluation of electronic, lipophilic and membrane affinity effects on antiproliferative activity of 5-substituted-2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles against various human cancer cells, Eur. J. Med. Chem., 42, 940, 10.1016/j.ejmech.2006.12.033 Prakash, 2008, Synthesis and antifungal activity of some new 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl) chromones, Eur. J. Med. Chem., 43, 435, 10.1016/j.ejmech.2007.04.004 Schenone, 2004, New pyrazolo [3,4-d] pyrimidines endowed with A431 anti-proliferative activity and inhibitory properties of Src phosphorylation, Bioorg. Med. Chem. Lett., 14, 2511, 10.1016/j.bmcl.2004.03.013 Schenone, 2006, New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities, Bioorg. Med. Chem., 14, 1698, 10.1016/j.bmc.2005.10.064 Solak, 2006, Synthesis and antituberculosis activity of 2-(aryl/alkylamino)-5-(4-aminophenyl)-1,3,4-thiadiazoles and their Schiff bases, Arkivoc, XII, 173, 10.3998/ark.5550190.0007.c20 Tandon, 2005, Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial and anticancer agents, Bioorg. Med. Chem. Lett., 15, 3288, 10.1016/j.bmcl.2005.04.066 Tanitame, 2005, Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles, Bioorg. Med. Chem. Lett., 15, 4299, 10.1016/j.bmcl.2005.06.103 Thomasco, 2003, The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues, Bioorg. Med. Chem., 13, 4193, 10.1016/j.bmcl.2003.07.018 Varvaresou, 1998, Synthesis, lipophilicity and biological evaluation of indole-containing derivatives of 1,3,4-thiadiazole and 1,2,4-triazole, IL. Farmaco., 53, 320, 10.1016/S0014-827X(98)00024-X Vicini, 2006, Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones, Bioorg. Med. Chem., 14, 3859, 10.1016/j.bmc.2006.01.043 Yusuf, 2008, Syntheses and anti-depressant activity of 5-amino-1,3,4-thiadiazole-2-thiol imines and thiobenzyl derivatives, Bioorg. Med. Chem., 17, 8029, 10.1016/j.bmc.2008.07.056