Synthesis and biological evaluation of technetium-sarafloxacin complex for infection imaging
Tóm tắt
Technetium-99m-sarafloxacin was synthesized and formulated for the development of a potential diagnostic imaging agent for the bacterial infection and inflammation with higher efficiency than the commercially available 99mTc-ciprofloxacin. Factors influencing the labeling yield such as sarafloxacin amount, pH of the labeling reaction, SnCl2 amount and reaction time were optimized. The labeled drug was subjected to preclinical evaluations in mice. The biodistribution studies indicated that 99mTc-sarafloxacin displayed relatively high uptake in the infectious lesion (T/NT = 4.2 ± 0.1) at 2 h post-injection. The results revealed that 99mTc-sarafloxacin cannot discriminate infection from sterile inflammation.
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