Synthesis and biological evaluation of novel quinolin-2(1H)-one derivatives as potential antimicrobial agents
Tóm tắt
A series of novel quinolin-2(1H)-one derivatives were synthesized and characterized by IR, 1H NMR, 13C NMR, and MS spectral data. All the new compounds were screened for their antimicrobial activities against six trains of bacteria and five fungi in vitro by twofold serial dilution technique. The bioactive assay showed that most of the compounds exhibited moderate to good antimicrobial activities in comparison with the streptomycin, especially, compound 6a, the fluoro-substituted aromatic amide derivative, showed good antibacterial activities against B.proteus and P.aeruginosa with minimal inhibitory concentration value of 32 and 16 μg/ml, respectively.
Tài liệu tham khảo
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