Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

Acta Pharmaceutica - Tập 63 Số 2 - Trang 231-239 - 2013
Priya V. Frank1, Mahesha M. Poojary2, Damodara Naral2, Chandrashekhar Chikkanna3
1Department of Chemistry, Canara Engineering College, Benjanapadavu Mangalore, Karnataka, India.
2Department of Chemistry, Canara Engineering College, Benjanapadavu Mangalore-574219, Karnataka, India
3PG Department of Medicinal Chemistry SDM College, Ujire-574240, Karnataka India

Tóm tắt

3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.

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Acta Pharmaceutica

Tập 63 Số 2

231-239

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