Synthesis and antimicrobial activity of some indole derivatives
Tóm tắt
Bromination of 2,3-diphenyl-5-methylindole (I) (using 3 mol) with bromine gave the 4,6-dibromo derivative (II) which upon oxidation gave the corresponding 2-benzamido benzophenone derivative (III). Bromination (using 6 mol) with bromine afforded the tetrabromo derivative (IVa) which reated with amines to form the corresponding 5-substituted aminomethyl derivatives (IVb-d). Further bromination ofII using only 1 mol gave the tribromo derivative (Va) which in turn reacted with amines to formVb-g. The antimicrobial activities of compoundsI, IVa, IVc, Va, Ve, Vf andVg were studied.
Tài liệu tham khảo
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