Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S

Villandangos, 1999, Immunol. Rev., 172, 109, 10.1111/j.1600-065X.1999.tb01360.x Shi, 1999, Immunity, 10, 197, 10.1016/S1074-7613(00)80020-5 Nakagawa, 1999, Immunol. Rev., 172, 121, 10.1111/j.1600-065X.1999.tb01361.x Honey, 2003, Nat. Immunol., 3, 472, 10.1038/nri1110 Beers, 2005, J. Immunol., 174, 1205, 10.4049/jimmunol.174.3.1205 Riese, 1996, Immunity, 4, 357, 10.1016/S1074-7613(00)80249-6 Driessen, 1999, J. Cell Biol, 147, 775, 10.1083/jcb.147.4.775 Yang, 2005, J. Immunol., 174, 1729, 10.4049/jimmunol.174.3.1729 Nakagawa, 1999, Immunity, 10, 207, 10.1016/S1074-7613(00)80021-7 Thurmond, 2005, Curr. Opin. Investig. Drugs, 6, 473 Wang, 2005, Expert Opin. Drug Deliv., 2, 1015, 10.1517/17425247.2.6.1015 Leroy, 2004, Expert Opin. Ther. Patents, 14, 301, 10.1517/13543776.14.3.301 Liu, 2005, Bioorg. Med. Chem. Lett., 15, 4979, 10.1016/j.bmcl.2005.08.017 Alper, 2006, Bioorg. Med. Chem. Lett., 16, 1486, 10.1016/j.bmcl.2005.12.056 Tully, 2006, Bioorg. Med. Chem. Lett., 16, 1975, 10.1016/j.bmcl.2005.12.095 Tully, 2006, Bioorg. Med. Chem. Lett., 16, 5112, 10.1016/j.bmcl.2006.07.033 Tully, 2006, Bioorg. Med. Chem. Lett., 16, 5107, 10.1016/j.bmcl.2006.07.032 Broadhurst, 1997, Bioorg. Med. Chem. Lett., 7, 2299;, 10.1016/S0960-894X(97)00416-2 Barlaam, 1999, J. Med. Chem., 42, 4890, 10.1021/jm990377j Xue, 2001, J. Med. Chem., 44, 3351, 10.1021/jm0155502 Kottirsch, 2002, J. Med. Chem., 45, 2289, 10.1021/jm0110993 Curtin, 2002, Bioorg. Med. Chem. Lett., 12, 2919, 10.1016/S0960-894X(02)00622-4 Cox, 1999, Drug Disc. Today, 4, 232, 10.1016/S1359-6446(98)01299-9 Korfmacher, 2001, Rapid Commun. Mass Spectrom., 15, 335, 10.1002/rcm.235 Evans, 1990, J. Am. Chem. Soc., 112, 4011, 10.1021/ja00166a045 Hoffmann, 2000, Angew. Chem. Intl. Ed., 39, 2054, 10.1002/1521-3773(20000616)39:12<2054::AID-ANIE2054>3.0.CO;2-Z