Synthesis and Characterization of Biodegradable and Cytocompatible Polyurethane-Egg Shell Derived Hydroxyapatite Biomaterials
Tóm tắt
Polyurethane is a biocompatible polymer for body tissue regeneration. To improve compatibility as a low-cost source, polyurethane was mixed with hydroxyapatite derived from chicken egg shells. The hydroxyapatite is a key mineral of bone to preserve the structure’s rigidity. The polyurethane was synthesized by prepolymer process and blended by solvent casting technique with egg shell derived hydroxyapatite. The presence of characteristic bands from FTIR spectra confirmed the synthesis of egg shell derived hydroxyapatite, polymer and composites. Egg shell derived hydroxyapatite’s crystallite size was 44 Å with a hexagonal structure. X-ray diffraction supported egg shell derived hydroxyapatite incorporation into the polyurethane matrix. Through egg shell derived hydroxyapatite applying to polyurethane, composites thermal strength has been greatly increased. Scanning electron microscopy has revealed a rough morphology of composites. In phosphate buffered saline, composites had superior biodegradability. The cytocompatible property of synthesized materials was identified in-vitro Methyltetrazolium bromide bioassay. With more egg shell derived hydroxyapatite, the cell viability of the polyurethane-egg shell derived hydroxyapatite composites improved. Such findings indicate a sustainable and economic solution for tissue regeneration to synthesize biodegradable and cytocompatible materials.
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