Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Lombardino G., 1985, Nonsteroidal Antiinflammatory Drugs

Clive D. M., 1984, N. Engl. J. Med., 310, 572, 10.1056/NEJM198403013100905

Pirson Y., 1986, Am. J. Kidney Dis., 8, 344, 10.1016/S0272-6386(86)80108-1

Allison M. C., 1992, N. Engl. J. Med., 327, 754, 10.1056/NEJM199209103271101

Haynes, R. C., Jr. Adrenocorticotropic Hormones; Adrenocortical Steroids and Their Synthetic Analogs; Inhibition of the Synthesis and Actions of Adrenocortical Hormones. InThe Pharmacological Basis ofTherapeutics, 8th ed.; Gilman, A. G., Rall, T. W., Nies, A. S., Taylor, P., Eds.; McGraw-Hill:  New York, 1993; pp 1442−1452.

Vane J. R, 1971, Nature [New Biol.], 231, 235, 10.1038/newbio231235a0

Smith J. B., 1971, Nature [New Biol.], 231, 237, 10.1038/newbio231235a0

Xie W., 1991, Proc. Natl. Acad. Sci. U.S.A., 88, 2696

Kujubu D. A., 1991, J. Biol. Chem., 266, 12872, 10.1016/S0021-9258(18)98774-0

Hla T., 1992, Proc. Natl. Acad. Sci. U.S.A., 89, 7388

Masferrer J. L., 1994, Proc. Natl. Acad. Sci. U.S.A., 91, 3232, 10.1073/pnas.91.8.3228

Reitz D. B., 1995, Curr. Pharm. Des., 1, 220, 10.2174/1381612801666220917221427

Reitz D. B., 1995, Annu. Rep. Med. Chem., 30, 188

Futaki N., 1994, Prostaglandins, 47, 59, 10.1016/0090-6980(94)90074-4

Li C. S., 1995, J. Med. Chem., 38, 4905

Gans K. R., 1990, J. Pharmacol. Exp. Ther., 254, 187

Reitz D. B., 1994, J. Med. Chem., 37, 3881

Reitz D. B., 1995, Med. Chem. Res., 5, 563

Li J. J., 1995, J. Med. Chem., 38, 4578

Seibert K., 1994, Proc. Natl. Acad. Sci. U.S.A., 91, 12017, 10.1073/pnas.91.25.12013

Recently, 1995, Selective Cyclooxygenase Inhibitor:  Novel 4-Spiro 1,2-Diarylcyclopentenes are Potent and Orally Active COX-2 Inhibitors. Bioorg. Med. Chem. Lett

Copeland R. A., 1994, Proc. Natl. Acad. Sci. U.S.A., 91, 11206, 10.1073/pnas.91.23.11202

Copeland R. A., 1995, Med. Chem. Res., 5, 393

Ouellet M., 1995, Biochem. J., 306, 251, 10.1042/bj3060247

Gierse J. K., 1995, Biochem. J., 305, 484, 10.1042/bj3050479

Winter C. A., 1962, Proc. Soc. Exp. Biol. Med., 111, 547, 10.3181/00379727-111-27849

Jaffee B. D., 1989, Agents Actions, 27, 346, 10.1007/BF01972818

Hargreaves K., 1988, Pain, 32, 88, 10.1016/0304-3959(88)90026-7

Hubbard R. C., 1996, J. Invest. Med., 44, 293A