Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives

Springer Science and Business Media LLC - Tập 18 Số 4 - Trang 4669-4678
Yahia N. Mabkhot1, Nabila A. Kheder2, Ahmad S. Shawali2
1Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia
2Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

Tóm tắt

A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a–c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile) (5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin B against Syncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G against Staphylococcus aureus. Moreover, it was more potent than the standard drug streptomycin against Pseudomonas aeruginosa and Escherichia coli.

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