Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms

Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol. 2004;5:738–43.

Zhang Y, Xia F, Liu X, Yu Z, Xie L, Liu L, et al. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/beta-catenin/CCND1 signaling. J Clin Invest. 2018;128:1737–51.

Testa U. Leukemia stem cells. Ann Hematol. 2011;90:245–71.

Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, et al. CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci U S A. 2007;104:11008–13.

Liu Y, Chen F, Wang S, Guo X, Shi P, Wang W, et al. Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors. Cell Death Dis. 2013;4:e948.

Alexaki A, Quiterio SJ, Nonnemacher MR, Shah S, Liu Y, Banerjee A, et al. Modeling bone marrow progenitor cell differentiation and susceptibility to HIV-1 infection. MOJ Immunol 2014;1:00009–00009.

Zhou XJ, Zhou YH, Chen XH, Qian WB. [Homoharringtonine combined arsenic trioxide induced apoptosis in human multiple myeloma cell line RPMI 8226: an experimental research]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2013;33:834–839 (in Chinese).

Chen P, Jiang X, You PD, Jin Q, Yuan Q, Huang HF. [Combination of homoharringtonine with arsenic trioxide induces apoptosis of human acute myeloid leukemia cell line U937]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016;24:1649–1653 (in Chinese).

Tohda S. NOTCH signaling roles in acute myeloid leukemia cell growth and interaction with other stemness-related signals. Anticancer Res. 2014;34:6259–64.

Kang R, Kroemer G, Tang D. The tumor suppressor protein p53 and the ferroptosis network. Free Rad Biol Medicine. 2018. https://doi.org/10.1016/j.freeradbiomed.2018.05.074.

Li X, Yin X, Wang H, Huang J, Yu M, Ma Z, et al. The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia. Oncotarget. 2017;8:12764–74.

Kannan S, Sutphin RM, Hall MG, Golfman LS, Fang W, Nolo RM, et al. Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med. 2013;210:321–37.

Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001;98:2301–7.

Chen P, Yuan Q, Yang H, Wen X, You P, Hou D, et al. Homoharringtonine enhances bortezomib antimyeloma activity in myeloma cells adhesion to bone marrow stromal cells and in SCID mouse xenografts. Leukemia Res. 2017;57:119–26.

Jung HJ, Chen Z, McCarty N. Synergistic anticancer effects of arsenic trioxide with bortezomib in mantle cell lymphoma. Am J Hematol. 2012;87:1057–64.

Guo Y, Shan Q, Gong Y, Lin J, Yang X, Zhou R. Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. Cancer Biol Ther. 2012;13:1244–54.

Wu Y, Tan M, Chen ML, Chen YZ. Expression and role of granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) and granulocyte colony-stimulating factor receptor (G-CSFR) on Ph-positive acute B lymphoblastic leukemia. Hematology. 2018;23:439–47.

Shen JP, Yang H, Ni WM, Qian WB. [Cytotoxicity of homoharringtonine on leukemic stem-like cells in AML cell line KG-1]. Zhejiang Da Xue Xue Bao Yi Xue ban. 2012;41:485–490 (in Chinese).

Wang L, You LS, Ni WM, Ma QL, Tong Y, Mao LP, et al. Beta-catenin and AKT are promising targets for combination therapy in acute myeloid leukemia. Leukemia Res. 2013;37:1329–40.

Fresno M, Jimenez A, Vazquez D. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977;72:323–30.

Ntziachristos P, Lim JS, Sage J, Aifantis I. From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell. 2014;25:318–34.

Sanchez-Martin M, Ferrando A. The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia. Blood. 2017;129:1124–33.

Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, et al. Notch pathway activation targets AML-initiating cell homeostasis and differentiation. J Exp Med. 2013;210:301–19.

Fu L, Kogoshi H, Nara N, Tohda S. NOTCH1 mutations are rare in acute myeloid leukemia. Leuk Lymph. 2006;47:2400–3.

Tohda S, Murata-Ohsawa M, Sakano S, Nara N. Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines. Int J Oncol. 2003;22:1073–9.

Okuhashi Y, Itoh M, Nara N, Tohda S. NOTCH knockdown affects the proliferation and mTOR signaling of leukemia cells. Anticancer Res. 2013;33:4293–8.