Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

Nature - Tập 403 Số 6771 - Trang 785-789 - 2000
Sha Mi1, Xinhua Lee1, Xiangping Li1, Geertruida M. Veldman1, Heather Finnerty1, Lisa Racie1, Edward R. LaVallie1, Xiang-Yang Tang1, Philippe Edouard1, Steve Howes1, James C. Keith1, John McCoy2,1
1Genetics Institute, Inc., Cambridge, USA
2Biogen, Inc., Cambridge, USA

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Ploegh, H. L. Viral strategies of immune evasion. Science 280, 248–253 (1998).

Blond, J.-L. et al. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. J. Virol. 73, 1175–1185 (1999).

Jacobs, K. A. et al. A genetic selection for isolating cDNAs encoding secreted proteins. Gene 198, 289– 296 (1997).

Cross, J. C., Werb, Z. & Fisher, S. J. Implantation and the placenta: key pieces of the development puzzle. Science 266, 1508– 1518 (1996).

Lala, P. K. & Hamilton, G. S. Growth factors, proteases and protease inhibitors in the maternal fetal dialog. Placenta 17, 545–555 (1996).

Munn, D. H. et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281, 1191–1193 (1998).

Yamada, S. & Ohnishi, S. Vesicular stomatitis virus binds and fuses with phospholipid domain in target cell membranes. Biochemistry 25, 3703–3708 ( 1986).

Pattillo, R. A., Gey, G. O., Delfs, E. & Mattingly, R. F. Human hormone production in vitro. Science 159, 1467–1469 (1968).

Lyden, T. W., Ng, A-K. & Rote, N. S. Modulation of phosphatidylserine epitope expression by BeWo cells during forskoloin treatment. Placenta 14, 177– 186 (1993).

Kohler, P. O. & Bridson, W. E. Isolation of hormone-producing clonal lines of human choriocarcinoma. J. Clin. Endocrinol. Metab. 32, 683–687 ( 1971).

Larsson, E. et al. Expression of an endogenous retrovirus, HERV-R, in human tissues. J. Cancer Res. Clin. Oncol. 119 (Suppl. 1), 6 (1993).

Boyd, M. T., Bax, C. M., Bax, B. E., Bloxam, D. L. & Weiss, R. A. The human endogenous retrovirus ERV-3 is upregulated in differentiating placental trophoblast cells. Virology 196, 905–909 (1993).

Venables, P. J., Brookes, S. M., Griffiths, D., Weiss, R. A. & Boyd, M. T. Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function. Virology 211, 589–592 (1995).

Limjoco, T. I., Dickie, P., Ikeda, H. & Silver, J. Transgenic Fv-4 mice resistant to Friend virus. J. Virol. 67, 4163–4168 (1993).

Best, S., Le Tissier, P., Towers, G. & Stoye, J. P. Positional cloning of the mouse retrovirus restriction gene Fv1. Nature 382, 826–829 (1996).

Kalter, S. S. et al. A comparative study on the presence of C-type viral particles in placentas from primates and other animals. Bibl. Haematol. 40, 391–401 (1975).

Harris, J. R. The evolution of placental mammals. FEBS Lett. 295, 3–4 (1991).

Pijnenborg, R., Robertson, W. B., Brosens, I. & Dixon, G. Trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta 2, 71–92 (1981).

Fox, H. in Pathology of the Placenta Chapter 6 (ed. Fox, H.) 151– 175 (W. B. Saunders, Philadelphia, 1997).

Baergen, R. N. Gestational choriocarcinoma. Gen. Diagn. Pathol. 143 , 127–141 (1997).

Cianciolo, G. J., Copeland, T. D., Oroszlan, S. & Snyderman, R. Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science 230, 453–455 (1985).

Kovats, S. et al. A class I antigen, HLA-G, expressed in human trophoblasts. Science 248, 220–223 ( 1990).

Hunt, J. S. Immunobiology of pregnancy. Curr. Opin. Immunol. 4, 591–596 (1992).

Cohen, M., Powers, M., O'Connell, C. & Kato, N. The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA. Virology 147, 449–458 (1985).

Larsson, E., Andersson, A. C. & Nilsson, B. O. Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues—evidence for a function for envelope gene products. Ups. J. Med. Sci. 99, 113–120 (1994).

Lin, L., Xu, B. & Rote, N. S. Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast. Placenta 20, 109–118 ( 1999).

Kaufman, R. J., Davies, M. V., Wasley, L. C. & Michnick, D. Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus. Nucleic Acids Res. 19, 4485–4490 (1991).

Sassoon, D. & Rosenthal, N. Detection of messenger RNA by in situ hybridization. Methods Enzymol. 225, 384–404 (1993).

Fischer, D., Weisenberger, D. & Scheer, U. Assigning functions to nucleolar structures. Chromosoma 101, 133–140 (1991).

Gately, M. K., Chizzonite, R. & Presky, D. H. in Current Protocols in Immunology 6. 16 (eds Coligan, J. E., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M. & Strober, W.) (Wiley, New York, 1996).