Sympathetic activation in congestive heart failure: Reproducibility of neuroadrenergic markers

European Journal of Heart Failure - Tập 10 Số 12 - Trang 1186-1191 - 2008
Guıdo Grassı1,2,3, G. Bolla1, Fosca Quartı-Trevano2, Francesca Arenare2, Gianmaria Brambilla2, Giuseppe Mancia1,2,3
1Centro di Fisiologica Clinica e Ipertensione Milan Italy
2Clinica Medica, Dipartimento di Medicina Clinica Prevenzione e Biotecnologie Sanitarie, Università Milano‐Bicocca, Ospedale San Gerardo Monza Milan Italy
3Istituto Auxologico Italiano, Milan, Italy

Tóm tắt

AbstractObjective:To assess the reproducibility of the two markers of adrenergic drive, venous plasma norepinephrine (NE) and efferent postganglionic muscle sympathetic nerve activity (MSNA), in reflecting the sympathetic activation characterizing congestive heart failure (CHF).Methods and measurements:In 19 CHF male normotensive patients (mean age: 53.0±2.1 years, NYHA classes II and III, left ventricular ejection fraction 35.9±2.9%), blood pressure (BP, Finapres), heart rate (EKG), plasma NE (HPLC assay) and MSNA (microneurography, peroneal nerve) were measured in two experimental sessions separated by a week interval. At each session, three NE samples were obtained and NE reproducibility between sessions was assessed by considering single NE samples or averaging 2–3 samples.Results:While MSNA values showed a highly significant correlation between sessions (r = 0.85, P<0.001), NE values based on a single blood sample evaluation did not correlate with each other (r = 0.41, P = NS). NE correlation coefficients improved and achieved statistical significance when average data from 2 and 3 blood samples were examined (r = 0.54 and r = 0.57, P<0.02 for both).Conclusions:In CHF, MSNA displays a better reproducibility pattern than plasma NE. The reproducibility of the NE approach, however, can be improved by performing the assay on multiple blood samples.

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Tài liệu tham khảo

10.1161/01.CIR.82.5.1724

10.1161/01.CIR.82.5.1730

10.1016/0735-1097(90)90544-Y

10.1016/0735-1097(93)90042-Y

10.1016/0735-1097(94)90385-9

10.1161/01.CIR.92.11.3206

10.1042/cs1010141

10.1161/01.CIR.73.5.913

10.1161/01.CIR.73.4.615

10.1016/0735-1097(94)90738-2

10.1161/01.CIR.93.9.1667

10.1161/01.HYP.0000098660.26184.63

10.1161/01.HYP.0000255983.32896.b9

10.1056/NEJM198409273111303

10.1016/0002-8703(87)90318-8

10.1053/euhj.2000.2407

10.1161/01.CIR.96.4.1173

10.1161/01.HYP.0000144271.59333.a7

10.1016/S1388-9842(99)00002-1

10.1042/cs0920285

Grassi G, Multiple sampling improves norepinephrine reproducibility in essential hypertension: a comparison with the microneurographic technique, J Hypertens in press

10.1161/01.CIR.60.4.760

10.1016/0024-3205(79)90384-9

10.1016/0024-3205(81)90139-9

Hjemdahl P., 1984, Catecholamine measurements by high performance liquid chromatography, Am J Physiol, 247, E13

10.1016/S0140-6736(86)90837-8

10.1097/00004872-199917060-00001

10.1152/physrev.1990.70.4.963

10.1046/j.1365-201X.2003.01089.x

10.1097/00004872-200110000-00003

10.1016/S1388-9842(03)00156-9

10.1161/01.CIR.96.11.4104

10.1097/00004872-199816110-00010

10.1056/NEJM197110142851602

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Thông tin xuất bản

European Journal of Heart Failure

Tập 10 Số 12

1186-1191

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