Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents
Tóm tắt
Three series of substituted sydnone sulfonamide derivatives were synthesized wherein 3-(4-methylphenyl)-4-(chlorosulfonyl)sydnone (5) was linked by a sulfonamide linkage with various thiazole, benzothiazole and quinazoline groups. The structures of the compounds were confirmed by IR and NMR spectroscopy and elemental analysis. The synthesized compounds were evaluated for their antibacterial, antifungal, antiproliferative and anti-HIV activities. Anti-HIV activity was determined against human immunodeficiency virus HIV-1 (III-B) and HIV-2 (ROD) in MT-4 cells. Inhibition of cytomegalovirus and varicella-zoster virus (VZV) replication was measured in human embryonic lung (HEL) cells.
Tài liệu tham khảo
S. M. El-Messery, G. S. Hassan, F. A. M. Al-Omary, and H. I. El-Subbagh, Eur. J. Med. Chem., 54, 615 – 625 (2012).
F. A. M. Al-Omary, G. S. Hassan, S. M. El-Messery, and H. I. El-Subbagh, Eur. J. Med. Chem., 47, 65 – 72 (2012).
S. H. L. Kok, R. Gambari, C. H. Chui, et al., Bioorg. Med. Chem., 16, 3626 – 3631 (2008).
A. M. Alafeefy and A. E. Ashour, J. Enzyme Inhib. Med. Chem., 27, 541 – 545 (2012).
B. E. Sleebs, P. E. Czabotar, W. J. Fairbrother, et al, J. Med. Chem., 54, 1914 – 1926 (2011).
M. J. Fregly, L. B. Kier, and D. Dhavan, Toxicol. Appl. Pharmacol. 6, 529 – 541 (1964).
C. S. Dunkley and C. J. Thoman, Bioorg. Med. Chem. Lett., 13, 2899 – 2901 (2003).
M. A. Moustafa, M. M. Gineinah, M. N. Nasr, and W. A. H. Bayoumi, Arch. Pharm., 337, 427–433 (2004).
K. Turnbull, T. L. Blackburn, and D. B. McClure, J. Heterocycl. Chem., 31, 1631–1636 (1994).
S. T. Asundaria and K. C. Patel, Synth. Commun., 40, 1899–1906 (2010).
N. S. Rai, B. Kalluraya, and B. Lingappa, Eur. J. Med. Chem., 43, 1715–1720 (2008).
D. R. Stalons and C. Thornsberry, Antimicrob. Agents Chemother., 7, 15–21 (1975).
V. J. Boyle, M. E. Fancher, and R. W. Ross, Antimicrob. Agents Chemother., 3, 418–424 (1973).
T. Kira, J.P. Merin, M. Baba, et al., AIDS Res. Hum. Retrovir., 11, 1359–1366 (1995).