Swelling behaviors, tensile properties and thermodynamic interactions in APS/HEMA copolymeric hydrogels
Tóm tắt
A series of hydrogels was synthesized from hydrophobic allyl phenyl sulfone (APS) and hydrophilic 2-hydroxyethyl methacrylate (HEMA) by bulk free radical copolymerization. The effects of APS content and temperature were studied on network parameters such as effective crosslink density (v
e), molar mass between crosslinks (M
c) and polymer-water interaction parameter (x) of hydrogels. The increase in APS content was shown to enhance hydrophobic bonding within hydrogel, leading to the decrease in equilibrium water content (EWC) and the increase in volume fraction of polymer in hydrogel (ϕ
2), tensile strength and Young’s modulus. At the same time, the increases in v
e and x and the decrease in M
c were also observed. When the temperature is increased from 273 to 343 K, the hydrogel A/H3 undergoes decreasing in EWC and increasing in ϕ
2 and x values. The thermody namic analysis indicated that the swelling process is an exothermic process.
Tài liệu tham khảo
Dai H J, Chen Q, Qin H L. A temperature-responsive copolymer hydrogel in controlled drug delivery. Macromolecules, 2006, 39(19): 6584–6589
Hennink W E, van Nostrum C F. Novel crosslinking methods to design hydrogels. Advanced Drug Delivery Reviews, 2002, 54(1): 13–36
Tsukeshiba H, Huang M, Na Y H, et al. Effect of polymer entanglement on the toughening of double network hydrogels. The Journal of Physical Chemistry B, 2005, 109(34): 16304–16309
Wang J Q, Wu W H. Swelling behaviors, tensile properties and thermodynamic studies of water sorption of 2-hydroxyethyl methacrylate/epoxy methacrylate copolymeric hydrogels. European Polymer Journal, 2005, 41(5): 1143–1151
Friends G, Künzler J, McGee J, et al. Hydrogels based on copolymers of N-(2-hydroxyethyl) methacrylamide, 2-hydroxyethyl methacrylate, and 4-t-butyl-2-hydroxycyclohexyl methacrylate. Journal of Applied Polymer Science, 1993, 49(11): 1869–1876
Jarvie A W P, Lloyd M C, Pourcain C B St. Novel hydrophilic cyclic monomers in hydrogel synthesis. Biomaterials, 1998, 19(21): 1957–1961
Clayton A B, Chirila T V, Lou X. Hydrophilic sponges based on 2-hydroxyethyl methacrylate. V. Effect of crosslinking agent reactivity on mechanical properties. Polymer International, 1997, 44(2): 201–207
Barnes A, Corkhill P H, Tighe B J. Synthetic hydrogels: 3. Hydroxyalkyl acrylate and methacrylate copolymers: Surface and mechanical properties. Polymer, 1988, 29(12): 2191–2202.
Abbasi F, Mirzadeh H, Katbab A A. Sequential interpenetrating polymer networks of poly(2-hydroxyethyl methacrylate) and polydimethylsiloxane. Journal of Applied Polymer Science, 2002, 85(9): 1825–1831
Lou X, Vijayasekaran S, Chirila T V, et al. Synthesis, physical characterization, and biological performance of sequential homointerpenetrating polymer network sponges based on poly(2-hydroxyethyl methacrylate). Journal of Biomedical Materials Research, 1999, 47(3): 404–411
Young C D, Wu J R, Tsou T L. High-strength, ultra-thin and fiber-reinforced pHEMA artificial skin. Biomaterials, 1998, 19(19): 1745–1752
Davis T P, Huglin M B. Effect of composition on properties of copolymeric N-vinyl-2-pyrrolidone/methyl methacrylate hydrogels and organogels. Polymer, 1990, 31(3): 513–519
Peppas N A, Merrill E W. Hydrogels as swollen elastic network. Journal of Applied Polymer Science, 1977, 21(7): 1763–1770
Peppas N A, Moynihan H J, Lucht L M. The structure of highly crosslinked poly (2-hydroxyethyl methacrylate) hydrogels. Journal of Biomedical Materials Research, 1985, 19(4): 397–411
Huglin M B, Rehab M M A M, Zakaria M B. Thermodynamic interactions in copolymeric hydrogels. Macromolecules, 1986, 19(12): 2986–2991