Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration

Shi, 2009, Recent developments of biodegradable and biocompatible materials based micro/nanoparticles for delivering macromolecular therapeutics, Critical Reviews in Therapeutic Drug Carrier Systems, 26, 29, 10.1615/CritRevTherDrugCarrierSyst.v26.i1.20 Farokhzad, 2009, Impact of nanotechnology on drug delivery, ACS Nano, 3, 16, 10.1021/nn900002m Tabata, 1999, Neovascularization effect of biodegradable gelatin microspheres incorporating basic fibroblast growth factor, Journal of Biomaterials Science, 10, 79, 10.1163/156856299X00298 Yamamoto, 2001, Controlled release of growth factors based on biodegradation of gelatin hydrogel, Journal of Biomaterials Science, 12, 77, 10.1163/156856201744461 Yamamoto, 2000, Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel, Journal of Controlled Release, 64, 133, 10.1016/S0168-3659(99)00129-7 Y. Kimura, Y. Tabata (2009), Controlled release of stromal cell-derived factor-1 from gelatin hydrogels enhances angiogenesis, Journal of Biomaterials Science 21(1) (2010) 37–51. Fukunaka, 2002, Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation, Journal of Controlled Release, 80, 333, 10.1016/S0168-3659(02)00026-3 Konishi, 2003, In vivo anti-tumor effect through the controlled release of cisplatin from biodegradable gelatin hydrogel, J Control Release, 92, 301, 10.1016/S0168-3659(03)00364-X Matsumoto, 2006, Cationized gelatin delivery of a plasmid DNA expressing small interference RNA for VEGF inhibits murine squamous cell carcinoma, Cancer Science, 97, 313, 10.1111/j.1349-7006.2006.00174.x Nakamura, 2008, Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model, American Journal of Pathology, 172, 650, 10.2353/ajpath.2008.061249 Mundy, 1999, Stimulation of bone formation in vitro and in rodents by statins, Science, 286, 1946, 10.1126/science.286.5446.1946 Yoon, 2004, Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method, Biomaterials, 25, 5613, 10.1016/j.biomaterials.2004.01.014 Dash, 2000, Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin, The Journal of Biological Chemistry, 275, 3793, 10.1074/jbc.275.6.3793 Lee, 2007, Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine), Journal of Controlled Release, 123, 19, 10.1016/j.jconrel.2007.08.006 Ghosh-Choudhury, 2007, Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation, Journal of Biological Chemistry, 282, 4983, 10.1074/jbc.M606706200 Yamamoto, 2003, Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein, Biomaterials, 24, 4375, 10.1016/S0142-9612(03)00337-5 Yoshihara, 2000, Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis, Annals of Rheumatic Diseases, 59, 455, 10.1136/ard.59.6.455 Lalani, 2005, Spatial and temporal localization of FGF-2 and VEGF in healing tooth extraction sockets in a rabbit model, Journal of Oral and Maxillofacial Surgery, 63, 1500, 10.1016/j.joms.2005.03.032 Fisher, 2004, Effect of biomaterial properties on bone healing in a rabbit tooth extraction socket model, Journal of Biomedical Materials Research Part A, 68, 428, 10.1002/jbm.a.20073 Marei, 2005, Preservation and regeneration of alveolar bone by tissue-engineered implants, Tissue Engineering, 11, 751, 10.1089/ten.2005.11.751