Quy trình nuôi cấy huyền phù cho virus cúm gia cầm H9N2 (chủng Re-2)

Tapia F, Vogel T, Genzel Y, Behrendt I, Hirschel M, Gangemi JD, Reichl U (2014) Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor. Vaccine 32(8):1003–1011. doi:10.1016/j.vaccine.2013.11.044 (Epub 2013/11/26) Bock A, Sann H, Schulze-Horsel J, Genzel Y, Reichl U, Mohler L (2009) Growth behavior of number distributed adherent MDCK cells for optimization in microcarrier cultures. Biotechnol Prog 25:1717–1731 Bottcher E, Freuer C, Steinmetzer T, Klenk HD, Garten W (2009) MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. Vaccine 27:6324–6329 Peschel B, Frentzel S, Laske T, Genzel Y, Reichl U (2013) Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 31(48):5693–5699 Genzel Y, Olmer RM, Schafer B, Reichl U (2006) Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media. Vaccine 24:6074–6087 Lohr V, Genzel Y, Behrendt I, Scharfenberg K, Reichl U (2010) A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 28(38):6256–6264 Jiang L, Changsom D, Lerdsamran H, Masamae W, Jongkaewwattana A, Iamsirithaworn S, Oota S, Louisirirotchanakul S, Auewarakul P, Puthavathana P (2016) Cross-reactive antibodies against H7N9 and H5N1 avian influenza viruses in Thai population. Asian Pac J Allergy Immunol Shin D, Park KJ, Lee H, Cho EY, Kim MS, Hwang MH, Kim SI, Ahn DH (2015) Comparison of immunogenicity of cell-and egg-passaged viruses for manufacturing MDCK cell culture-based influenza vaccines. Virus Res 204:40–46 Li LJ, Li Q, Shi XY, Zhao SJ, Zhang H, Shi CH (2000) Evaluation of neoplastigenesis of 5 types of passage animal cell lines in nude mice. J Fourth Military Med Univ 21(6) (ISSN: 81-5046/R) Please provide Ref. [10] as it missing in the list, but citation was provided Lohr V, Genzel Y, Behrendt I, Scharfenberg K, Reichl U (2010) A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 28:6256–6264 Zhang DL, Li LJ, Xia GT, He X, Gao B, Bai X, Huang G, Liu S, Yan L, de Fang F (2002) Experimental research on carcinogenesis or tumorigenicity of MDCK canine kidney cell (CKC) lines and analysis of their chromosome karyotypes. Sci Agric Sin 35(5) (ISSN: 0578-1752) Negrete A, Pai A, Shiloach J (2014) Use of hollow fiber tangential flow filtration for the recovery and concentration of HIV virus-like particles produced in insect cells. J Virol Methods 195:240–246 Wang JH, Shao M, Shi CH, Bi JL, Yin GF (2011) Reducing the side effects of FMD type O, Asia-1 inactivated vaccine by purification and concentration of antigen. Chin J Prevent Vet Med 33(1) (ISSN: 1008-0589) Sun Y, Liu J (2015) H9N2 influenza virus in China: a cause of concern. Protein Cell 6:18–25 Xu YL, Dong YJ, Wang S (2015) Study on the reproduction and hemagglutination activity of H9N2 influenza virus in chicken embryo. Heilongjiang Anim Sci Vet Med 23:166–168 (ISSN: 1004-7034) Chen X, Zhang M, Zhang Q, Wang L, Wang D, Jiang T (2013) The construction and preliminary application of double-gene express vector that express Siat7e gene and St3 galIGene simultaneously Chin J Vet Drug (04) (ISSN: 1002-1280) Chu Chia, Lugovtsev Vladimir, Lewis Andrew, Betenbaugh Michael, Shiloach Joseph (2010) Production and antigenic properties of influenza virus from suspension MDCK-siat7e cells in a bench-scale bioreactor. Vaccine 28(44):7193–7201 Wen Z, Wu C, Chen W, Zeng X, Shi J, Ge J, Chen H, Bu Z (2015) Establishment of MDCK stable cell lines expressing TMPRSS2 and MSPL and their applications in propagating influenza vaccine viruses in absence of exogenous trypsin. Biotechnol Res Int 2015:402628 Genzel Y, Dietzsch C, Rapp E, Schwarzer J, Reichl U (2010) MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation. Appl Microbiol Biotechnol 88(2):461–475. doi:10.1007/s00253-010-2742-9 Xu KM, Smith GJ, Bahl J, Duan L, Tai H, Vijaykrishna D, Wang J, Zhang JX, Li KS, Fan XH, Webster RG, Chen H, Peiris JS, Guan Y (2007) The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000–2005. J Virol 81:10389–10401 Chu C, Lugovtsev V, Golding H, Betenbaugh M, Shiloach J (2009) Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production. Proc Natl Acad Sci 106(35):14802–14807 Van Wielink R, Kant-Eenbergen H, Harmsen M, Martens D, Wijffels R, Coco-Martin J (2011) Adaptation of a Madin–Darby canine kidney cell line to suspension growth in serum-free media and comparison of its ability to produce avian influenza virus to Vero and BHK21 cell lines. J Virol Methods 171(1):53–60. doi:10.1016/j.jviromet.2010.09.029 Grner A, Vorlop J (2002) Animal cells and processes for the replication of influenza viruses. Google Patents Pau M, Ophorst C, Koldijk MH, Schouten G, Mehtali M, Uytdehaag F (2001) The human cell line PER. C6 provides a new manufacturing system for the production of influenza vaccines. Vaccine 19(17):2716–2721 Lohr V, Rath A, Genzel Y, Jordan I, Sandig V, Reichl U (2009) New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27(36):4975–4982. doi:10.1016/j.vaccine.2009.05.083 Mehtali M, Champion-arnaud P, Leon A (2006) Process of manufacturing viral vaccines in suspension avian embryonic derived stem cell lines. WO Patent 2,006,108,846 Genzel Y, Reichl U (2009) Continuous cell lines as a production system for influenza vaccines. Expert Rev Vaccines 8(12):1681–1692. doi:10.1586/erv.09.128 Genzel Y, Vogel T, Buck J, Behrendt I, Ramirez DV, Schiedner G et al (2014) High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells. Vaccine Genzel Y, Behrendt I, Rödig J, Rapp E, Kueppers C, Kochanek S et al (2013) CAP, a new human suspension cell line for influenza virus production. Appl Microbiol Biotechnol 97(1):111–122. doi:10.1007/s00253-012-4238-2 Butler M, Burgener A, Patrick M, Berry M, Moffatt D, Huzel N et al (2000) Application of a serum-free medium for the growth of Vero cells and the production of reovirus. Biotechnol Prog 16(5):854–858 Fishbein DB, Yenne KM, Dreesen DW, Teplis CF, Mehta N, Briggs DJ (1993) Risk factors for systemic hypersensitivity reactions after booster vaccinations with human diploid cell rabies vaccine: a nationwide prospectivestudy. Vaccine 11(14):1390–1394 Henry O, Dormond E, Perrier M, Kamen A (2004) Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures. Biotechnol Bioeng 86(7):765–774 Pohlscheidt M, Langer U, Minuth T, Bödeker B, Apeler H, Hörlein H-D et al (2008) Development and optimization of a procedure for the production of <i> Parapoxvirus ovis by large-scale microcarrier cell culture in a non-animal, non-human and non-plant-derived medium. Vaccine 26(12):1552–1565. doi:10.1016/j.vaccine.2008.01.032