Susceptibility to Gastric Cancer and Polymorphisms of Insertion/Deletion at the Intron 3 of the XRCC4 and VNTR at the Promoter Region of the XRCC5

Gao S, Zhang X, Wang P, Dai L, Zhang J, Wang K (2011) Genetic epidemiological analysis reveals a multi-gene additive model for gastric cancer. Fam Cancer 10:119–125 Drăghicescu T, Roman IC, Păltănea L (1998) Epidemiologic research on the genetic risk factors in gastric and colorectal cancer. Rom J Morphol Embryol 44:149–152 Gilley D, Tanaka H, Hande MP, Kurimasa A, Li GC, Oshimura M, Chen DJ (2001) DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A 98:15084–15088 Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE et al (2000) DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404:510–514 Ferguson DO, Alt FW (2001) DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 20:5572–5579 Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM et al (2000) Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404:897–900 Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J et al (2002) Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 109:811–821 Pfeiffer P, Goedecke W, Kuhfittig-Kulle S, Obe G (2004) Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations. Cytogenet Genome Res 104:7–13 Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A, Lipscombe JM et al (2002) Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet 11:1399–1407 Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD et al (1995) The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83:1079–1089 Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ et al (1998) A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95:891–902 Chang CH, Chiu CF, Wu HC, Tseng HC, Wang CH, Lin CC et al (2008) Significant association of XRCC4 single nucleotide polymorphisms with prostate cancer susceptibility in Taiwanese males. Mol Med Rep 1:525–530 Mandal RK, Singh V, Kapoor R, Mittal RD (2011) Do polymorphisms in XRCC4 influence prostate cancer susceptibility in North Indian population? Biomarkers 16:236–242 Chiu CF, Tsai MH, Tseng HC, Wang CL, Wang CH, Wu CN et al (2008) A novel single nucleotide polymorphism in XRCC4 gene is associated with oral cancer susceptibility in Taiwanese patients. Oral Oncol 44:898–902 Wu KH, Wang CH, Yang YL, Peng CT, Lin WD, Tsai FJ et al (2010) Significant association of XRCC4 single nucleotide polymorphisms with childhood leukemia in Taiwan. Anticancer Res 30:529–533 Rajaei M, Saadat I, Saadat M (2012) Introducing a novel allele for the polymorphism of variable number of tandem repeats in the promoter region of XRCC5. Biochem Biophys Res Commun 427:503–505 Rajaei M, Saadat I, Saadat M (2013) The novel allele (3R) of the VNTR polymorphism in the XRCC5 promoter region dramatically decreases the gene expression. Biochem Biophys Res Commun 430:640–641 Lim JW, Kim H, Kim KH (2002) Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. J Biol Chem 277:46093–46100 Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y, Enomoto A, Morita A et al (2004) Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. Int J Oncol 25:461–468 Chang HW, Kim SY, Yi SL, Son SH, Song do Y, Moon SY et al (2006) Expression of Ku80 correlates with sensitivities to radiation in cancer cell lines of the head and neck. Oral Oncol 42:979–986 Gorre M, Mohandas PE, Kagita S, Annamaneni S, Digumarti R, Satti V (2014) Association of XRCC5 VNTR polymorphism with the development of chronic myeloid leukemia. Tumour Biol 35:923–927 Wang S, Wang M, Yin S, Fu G, Li C, Chen R et al (2008) A novel variable number of tandem repeats (VNTR) polymorphism containing Sp1 binding elements in the promoter of XRCC5 is a risk factor for human bladder cancer. Mutat Res 638:26–36 Dong XJ, Wang N, Guo W, Zhou RM, Zhang XJ, Li Y (2007) Correlations of XRCC5 polymorphisms to genetic susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a high incidence region. Ai Zhengzhou 26:280–284 [Chinese] Li R, Yang Y, An Y, Zhou Y, Liu Y, Yu Q et al (2011) Genetic polymorphisms in DNA double-strand break repair genes XRCC5, XRCC6 and susceptibility to hepatocellular carcinoma. Carcinogenesis 32:530–536 Yang MD, Tsai CW, Chang WS, Tsou YA, Wu CN, Bau DT (2011) Predictive role of XRCC5/XRCC6 genotypes in digestive system cancers. World J Gastrointest Oncol 3:175–181 Rajaei M, Saadat I, Omidvari S, Saadat M (2014) Association between polymorphisms at promoters of XRCC5 and XRCC6 genes and risk of breast cancer. Med Oncol 31:885 Rafiee L, Saadat I, Saadat M (2010) Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. Mol Biol Rep 37:155–158 Mohamadynejad P, Saadat M (2008) Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran). Mol Biol Rep 35:669–672 Rajaei M, Saadat I, Saadat M (2012) High resolution melting analysis for detection of variable number of tandem repeats polymorphism of XRCC5. Biochem Biophys Res Commun 425:398–400 Liu J, Shu T, Chang S, Sun P, Zhu H, Li H (2014) Risk of malignancy associated with a maternal family history of cancer. Asian Pac J Cancer Prev 15:2039–2044 Jiang X, Tseng CC, Bernstein L, Wu AH (2014) Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study. BMC Cancer 14:60 Turati F, Negri E, La Vecchia C (2014) Family history and the risk of cancer: genetic factors influencing multiple cancer sites. Expert Rev Anticancer Ther 14:1–4