Susceptibility of Healthy Volunteers’ Adaptive Immune Cells to MSC-Mediated Immunomodulation in Long-Term “Dry” Immersion Experiment
Tóm tắt
The susceptibility of T cells of healthy subjects during 21 days of “dry” immersion (DI) to MSC-mediated immunosuppression was investigated in vitro. During DI, the expression of the late activation (HLA-DR) marker and paracrine activity were increased in PHA-stimulated T cells. Proliferation was decreased, and Th1/Th2 balance was shifted towards Th1. MSCs possessed immunomodulatory properties in co-culture with T cells of healthy subjects in background, as well as during DI suppressing late activation, proliferation and shifting the balance of cytokines to Th2. However, the antiproliferative effect of MSCs was not always detected and depended on the initial response of T cells to a mitogen. In addition, the ability of MSCs to “smooth” the effects of “dry” immersion was demonstrated.
Tài liệu tham khảo
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