Survivin Knockdown Enhances Gastric Cancer Cell Sensitivity to Radiation and Chemotherapy In Vitro and in Nude Mice

2011 Section of Cancer Information, IARC, 2011 Gou, 2011, Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications, J Exp Clin Cancer Res, 30, 14, 10.1186/1756-9966-30-14 Arkenau, 2009, Gastric cancer in the era of molecularly targeted agents: current drug development strategies, J Cancer Res Clin Oncol, 135, 855, 10.1007/s00432-009-0583-7 Yasui, 2006, Molecular pathobiology of gastric cancer, Scand J Surg, 95, 225, 10.1177/145749690609500403 Chen, 2008, Inhibitory effect of siRNA targeting survivin in gastric cancer MGC-803 cells, Int Immunopharmacol, 8, 1006, 10.1016/j.intimp.2008.03.004 Miao, 2007, Downregulation of survivin by RNAi inhibits growth of human gastric carcinoma cells, World J Gastroen-terol, 13, 1170, 10.3748/wjg.v13.i8.1170 Sah, 2006, Structural, functional and therapeutic biology of survivin, Cancer Lett, 244, 164, 10.1016/j.canlet.2006.03.007 Pennati, 2007, Targeting survivin in cancer therapy: fulfilled promises and open questions, Carcinogenesis, 28, 1133, 10.1093/carcin/bgm047 Altieri, 2003, Validating survivin as a cancer therapeutic target, Nat Rev Cancer, 3, 46, 10.1038/nrc968 Song, 2008, Survivin gene RNA interference inhibits proliferation, induces apoptosis, and enhances radiosensitivity in HeLa cells, Eur J Obstet Gynecol Reprod Biol, 136, 83, 10.1016/j.ejogrb.2006.07.057 Croci, 2008, Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway, J Cell Biochem, 105, 381, 10.1002/jcb.21836 Zaffaroni, 2007, Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma, Cell Oncol, 29, 453 Cai, 2009, Enhanced chemotherapy sensitivity of human colon cancer cells to 5-fluorouracil by siRNA recombinant expression vector targeting survivin gene, Chin Med Sci J, 24, 97, 10.1016/S1001-9294(09)60069-9 Virrey, 2008, Increased survivin expression confers chemoresistance to tumor-associated endothelial cells, Am J Pathol, 173, 575, 10.2353/ajpath.2008.071079 Yang, 2008, Influence of SiRNA targeting survivin on chemosensitivity of H460/cDDP lung cancer cells, J Int Med Res, 36, 734, 10.1177/147323000803600416 Fan, 2008, Role of hypoxia-inducible factor-1 alpha and survivin in colorectal carcinoma progression, Int J Colorectal Dis, 23, 1057, 10.1007/s00384-008-0511-3 Moriai, 2009, Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells, Breast Cancer Res Treat, 117, 261, 10.1007/s10549-008-0164-5 Ma, 2007, Exploration on the increased sensitivity to docetaxel and reversing mechanism of drug resistance of antisense survivin RNA in gastric cancer cell line SGC7901 cells, Zhonghua Zhong Liu Za Zhi, 29, 89 Hannan, 2002, RNA interference[J], Nature, 418, 244, 10.1038/418244a