Survival outcome of patients with nasopharyngeal carcinoma: a nationwide analysis of 13 407 patients in Taiwan

Clinical Otolaryngology - Tập 40 Số 4 - Trang 327-334 - 2015
Wenhua Huang1,2, Cheng‐Li Lin3,4, Chun‐Yen Lin5, Yee–Min Jen1, Cheng‐Hsiang Lo1, Fung-Chang Sung6,4, Chia‐Tze Kao7,6
1Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
2Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
3College of Medicine, China Medical University, Taichung, Taiwan
4Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
5Department of Radiation Oncology, Chang Gung Memorial Hospital–Linkou, Chang Gung University, Taoyuan, Taiwan
6Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan
7Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

Tóm tắt

ObjectivesWe reported the contemporary survival outcome of patients with nasopharyngeal carcinoma (NPC) and analysed the factors affecting survival.DesignA retrospective cohort study.SettingA nationwide population‐based study in Taiwan.ParticipantsWe identified 13 407 patients with newly diagnosed NPC from 2002 to 2010.Material and MethodsThe multivariate Cox proportional hazards model was performed to measure the mortality‐association risk factor in patients with NPC after adjusting for NPC treatment and socio‐demographic characteristics.ResultsThe 1‐, 2‐, 5‐ and 8‐year overall survival (OS) rates were 89.6%, 80.4%, 65.2% and 56.5%, respectively. The factors associated with mortality risk were sex (men versus women, HR  =  1.45), age (>60 versus ≤ 40 years, HR  =  3.61), geographic region of residence (eastern Taiwan versus northern Taiwan HR   =   1.39), income (<15 840 versus >25  000, HR   =   1.87) and treatment modality (chemotherapy alone versus radiotherapy alone, HR   =   2.25).ConclusionThe contemporary 5‐year OS rate was 65.2% in Taiwan. Male patients, old age, residing in eastern Taiwan, low income and receiving chemotherapy alone were independent predictors for poor OS.

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Clinical Otolaryngology

Tập 40 Số 4

327-334

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