Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

Journal of Experimental Medicine - Tập 186 Số 8 - Trang 1223-1232 - 1997
Thomas Brocker1
1From the Basel Institute for Immunology, CH-4005 Basel, Switzerland

Tóm tắt

Thymic T cell development is controlled by T cell receptor (TCR)–major histocompatibility complex (MHC) interactions, whereas a further dependence of peripheral mature T cells on TCR–MHC contact has not been described so far. To study this question, CD4 T cell survival was surveyed in mice lacking MHC class II expression and in mice expressing MHC class II exclusively on dendritic cells. Since neither of these mice positively select CD4 T cells in the thymus, they were grafted with MHC class II–positive embryonic thymic tissue, which had been depleted of bone marrow derived cells. Although the thymus grafts in both hosts were repopulated with host origin thymocytes of identical phenotype and numbers, an accumulation of CD4+ T cells in peripheral lymphoid organs could only be observed in mice expressing MHC class II on dendritic cells, but not in mice that were completely MHC class II deficient. As assessed by histology, the accumulating peripheral CD4 T cells were found to be in close contact with MHC class II+ dendritic cells, suggesting that CD4 T cells need peripheral MHC class II expression for survival and that class II+ dendritic cells might play an important role for the longevity of CD4 T cells.

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Tài liệu tham khảo

Jameson, 1995, Positive selection of thymocytes, Annu Rev Immunol, 13, 93, 10.1146/annurev.iy.13.040195.000521

Nossal, 1994, Negative selection of lymphocytes, Cell, 76, 229, 10.1016/0092-8674(94)90331-X

Anderson, 1996, Cellular interactions in thymocyte development, Annu Rev Immunol, 14, 73, 10.1146/annurev.immunol.14.1.73

Kontgen, 1993, Targeted disruption of the MHC class II Aa gene in C57BL/6 mice, Int Immunol, 5, 957, 10.1093/intimm/5.8.957

Gosgrove, 1991, Mice lacking MHC class II molecules, Cell, 66, 1051, 10.1016/0092-8674(91)90448-8

von Boehmer, 1993, The life span of naive alpha/beta T cells in secondary lymphoid organs, J Exp Med, 177, 891, 10.1084/jem.177.4.891

Bruno, 1995, On the cellular basis of immunological T cell memory, Immunity, 2, 37, 10.1016/1074-7613(95)90077-2

Sprent, 1991, Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype, J Exp Med, 174, 717, 10.1084/jem.174.3.717

Markowitz, 1993, Class II–positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II–deficient mice, Proc Natl Acad Sci USA, 90, 2779, 10.1073/pnas.90.7.2779

Huss, 1994, Major histocompatibility complex class II expression is required for posttransplant immunological but not hemopoietic reconstitution in mice, Transplantation (Baltimore), 58, 1366

Takeda, 1996, MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span, Immunity, 5, 217, 10.1016/S1074-7613(00)80317-9

Frey, 1992, Thymus-grafted SCID mice show transient thymopoiesis and limited depletion of V beta 11+ T cells, J Exp Med, 175, 1067, 10.1084/jem.175.4.1067

Brocker, 1997, Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo, J Exp Med, 185, 541, 10.1084/jem.185.3.541

Breel, 1987, Dendritic cells of the mouse recognized by two monoclonal antibodies, Eur J Immunol, 17, 1555, 10.1002/eji.1830171105

Riedinger, 1997, Targeted expression of MHC class II genes to dendritic cells in vivo, Immunol Lett, 57, 155, 10.1016/S0165-2478(97)00074-6

Agger, 1990, The surface of dendritic cells in the mouse as studied with monoclonal antibodies, Int Rev Immunol, 6, 89, 10.3109/08830189009056621

Ruedl, 1996, Phenotypic and functional characterisation of CD11c+ dendritic cell population in mouse Peyer's patches, Eur J Immunol, 26, 1801, 10.1002/eji.1830260821

Nussenzweig, 1982, A monoclonal antibody specific for mouse dendritic cells, Proc Natl Acad Sci USA, 79, 161, 10.1073/pnas.79.1.161

Crowley, 1989, The cell surface of mouse dendritic cells: FACS®analyses of dendritic cells from different tissues including thymus, Cell Immunol, 118, 108, 10.1016/0008-8749(89)90361-4

Kraal, 1986, Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody, J Exp Med, 163, 981, 10.1084/jem.163.4.981

Agger, 1992, Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytes, J Leukocyte Biol, 52, 34, 10.1002/jlb.52.1.34

Ardavin, 1997, Thymic dendritic cells, Immunol Today, 18, 350, 10.1016/S0167-5699(97)01090-6

Zinkernagel, 1980, Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2–compatible or –incompatible thymus grafts, J Exp Med, 151, 376, 10.1084/jem.151.2.376

Ready, 1984, Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens, Nature (Lond), 310, 231, 10.1038/310231a0

von Boehmer, 1984, Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells, Eur J Immunol, 14, 1048, 10.1002/eji.1830141116

Wilson, 1988, Subpopulations of mature murine thymocytes: properties of CD4-CD8+ and CD4+CD8- thymocytes lacking the heat-stable antigen, Cell Immunol, 117, 312, 10.1016/0008-8749(88)90121-9

Swat, 1993, CD69 expression during selection and maturation of CD4+8+ thymocytes, Eur J Immunol, 23, 739, 10.1002/eji.1830230326

Kirberg, 1996, CD45 up-regulation during lymphocyte maturation, Int Immunol, 8, 1743, 10.1093/intimm/8.11.1743

Tanchot, 1997, Differential requirements for survival and proliferation of CD8 naive or memory T cells, Science (Wash DC), 276, 2057, 10.1126/science.276.5321.2057

Benoist, 1997, Selection for survival?, Science (Wash DC), 276, 2000, 10.1126/science.276.5321.2000

Steinman, 1991, The dendritic cell system and its role in immunogenicity, Annu Rev Immunol, 9, 271, 10.1146/annurev.iy.09.040191.001415

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Journal of Experimental Medicine

Tập 186 Số 8

1223-1232

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