Surgical management of secondary hyperparathyroidism in chronic kidney disease—a consensus report of the European Society of Endocrine Surgeons

Springer Science and Business Media LLC - Tập 400 Số 8 - Trang 907-927 - 2015
Kerstin Lorenz1, Detlef K. Bartsch2, J. Sancho3, Sébastien Guigard4, Frédéric Triponez5
1Department of General-, Visceral-, and Vascular Surgery, Martin-Luther University of Halle-Wittenberg, Ernst-Grube-Str. 40, Halle (Saale), 06120, Germany
2Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstraße 1, Marburg, 35043, Germany
3Department of General Surgery, Endocrine Surgery Unit, Hospital del Mar, Universitat Autònoma de Barcelona, Passeig Marítim 25-29, Barcelona, 08003, Spain
4Department of Thoracic and Endocrine Surgery, University Hospitals of Geneva, Switzerland, Rue Gabrielle Perret-Gentil 4, 14, Geneva, 1211, Switzerland
5Chirurgie thoracique et endocrinienne, Hôpitaux Universitaires de Genève, Rue Gabrielle Perret-Gentil 4, 14, Geneva, 1211, Switzerland

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Tentori F, Wang M, Bieber BA, Karaboyas A, Li Y, Jacobson SH et al (2015) Recent changes in therapeutic approaches and association with outcomes among patients with secondary hyperparathyroidism on chronic hemodialysis: The DOPPS Study. Clin J Am Soc Nephrol 10(1):98–109

Ishani A, Liu J, Wetmore JB, Lowe KA, Do T, Bradbury BD et al (2015) Clinical outcomes after parathyroidectomy in a nationwide cohort of patients on hemodialysis. Clin J Am Soc Nephrol 10(1):90–97

Sackett DL. Evidence-based medicine. Wiley; 2000.

Heinrich S, Schäfer M, Rousson V, Clavien P-A (2006) Evidence-based treatment of acute pancreatitis: a look at established paradigms. Ann Surg 243(2):154

Pitt SC, Sippel RS, Chen H (2009) Secondary and tertiary hyperparathyroidism, state of the art surgical management. Surg Clin North Am 89(5):1227–1239

Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl 113:S1

Kidney Foundation (2003) K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kid Dis 42(S1)

Tominaga Y, Matsuoka S, Sato T (2005) Surgical indications and procedures of parathyroidectomy in patients with chronic kidney disease. Ther Apher Dial 9(1):44–47

Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM (2004) Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 15(8):2208–2218

Eknoyan G, Levin NW (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39(2 Suppl 1):S1–S266

Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2013) KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney International Supplements 3(1):1–150

Young EW, Albert JM, Satayathum S, Goodkin DA, Pisoni RL, Akiba T et al (2005) Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study. Kidney Int 67(3):1179–1187

Matsuoka S, Tominaga Y, Sato T, Uno N, Hiramitu T, Goto N et al (2008) Relationship between the dimension of parathyroid glands estimated by ultrasonography and the hyperplastic pattern in patients with renal hyperparathyroidism. Ther Apher Dial 12(5):391–395

Chroustova D, Kubinyi J, Trnka J, Adamek S (2014) The role of 99mTc-MIBI SPECT/low dose CT with 3D subtraction in patients with secondary hyperparathyroidism due to chronic kidney disease. Endocr Regul 48(2):55–63

Michaud L, Burgess A, Huchet V, Lefevre M, Tassart M, Ohnona J et al (2014) Is 18F-fluorocholine-positron emission tomography/computerized tomography a new imaging tool for detecting hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism? J Clin Endocrinol Metab 99(12):4531–4536

Alkhalili E, Tasci Y, Aksoy E, Aliyev S, Soundararajan S, Taskin E et al (2015) The utility of neck ultrasound and sestamibi scans in patients with secondary and tertiary hyperparathyroidism. World J Surg 39(3):701–705

Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG et al (2004) Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 350(15):1516–1525

Vervloet M, du Buf-Vereijken P, van Loon BP, Manamley N, Reichert L, Gregoor PS (2013) Cinacalcet for secondary hyperparathyroidism: from improved mineral levels to improved mortality? Neth J Med 71(7):348–354

Moe SM, Cunningham J, Bommer J, Adler S, Rosansky SJ, Urena-Torres P et al (2005) Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl. Nephrol Dial Transplant 20(10):2186–2193

Raggi P, Chertow GM, Torres PU, Csiky B, Naso A, Nossuli K et al (2011) The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis. Nephrol Dial Transplant 26(4):1327–1339

Ketteler M, Martin KJ, Wolf M, Amdahl M, Cozzolino M, Goldsmith D et al (2012) Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study. Nephrol Dial Transplant 27(8):3270–3278

Goldsmith D, Covic A, Vervloet M, Cozzolino M, Nistor I, Chronic Kidney Disease-Mineral Bone Disease Working Group et al (2015) Should patients with CKD stage 5D and biochemical evidence of secondary hyperparathyroidism be prescribed calcimimetic therapy? An ERA-EDTA position statement. Nephrol Dial Transplant 30(5):698–700

Moe SM, Chertow GM, Coburn JW, Quarles LD, Goodman WG, Block GA et al (2005) Achieving NKF-K/DOQI™ bone metabolism and disease treatment goals with cinacalcet HCl. Kidney Int 67(2):760–771

Prieto FT, Blanco GB, Garcia MN, Chaves VC, GarcíaJiménez R, Palomo PP et al (2009) Calcimimetics and bone mineral density in renal transplant patients with persistent secondary hyperparathyroidism. Transplant Proc 41(6):2144–2147

Weber KJ, Misra S, Lee JK, Wilhelm SW, DeCresce R, Prinz RA (2004) Intraoperative PTH monitoring in parathyroid hyperplasia requires stricter criteria for success. Surgery 136(6):1154–1159

Tominaga Y, Matsuoka S, Uno N, Sato T (2008) Parathyroidectomy for secondary hyperparathyroidism in the era of calcimimetics. Ther Apher Dial 12(s1):S21–S26

Kovacevic B, Ignjatovic M, Zivaljevic V, Cuk V, Scepanovic M, Petrovic Z et al (2012) Parathyroidectomy for the attainment of NKF-K/DOQI and KDIGO recommended values for bone and mineral metabolism in dialysis patients with uncontrollable secondary hyperparathyroidism. Langenbecks Arch Surg 397(3):413–420

Mazzaferro S, Pasquali M, Farcomeni A, Vestri AR, Filippini A, Romani AM et al (2008) Parathyroidectomy as a therapeutic tool for targeting the recommended NKF-K/DOQI ranges for serum calcium, phosphate and parathyroid hormone in dialysis patients. Nephrol Dial Transplant 23(7):2319–2323

Stanbury S, Lumb G, Nicholson W (1960) Elective subtotal parathyroidectomy for renal hyperparathyroidism. Lancet 275(7128):793–798

Madorin C, Owen RP, Fraser WD, Pellitteri PK, Radbill B, Rinaldo A et al (2012) The surgical management of renal hyperparathyroidism. Eur Arch Otorhinolaryngol 269(6):1565–1576

Schneider R, Bartsch DK (2015) Role of surgery in the treatment of renal secondary hyperparathyroidism. Br J Surg 102(4):289–290

Gasparri G, Camandona M, Abbona GC, Papotti M, Jeantet A, Radice E et al (2001) Secondary and tertiary hyperparathyroidism: causes of recurrent disease after 446 parathyroidectomies. Ann Surg 233(1):65

Tominaga Y, Katayama A, Sato T, Matsuoka S, Goto N, Haba T et al (2003) Re-operation is frequently required when parathyroid glands remain after initial parathyroidectomy for advanced secondary hyperparathyroidism in uraemic patients. Nephrol Dial Transplant 18(3):iii65–iii70

Triponez F, Kebebew E, Dosseh D, Duh QY, Hazzan M, Noel C et al (2006) Less-than-subtotal parathyroidectomy increases the risk of persistent/recurrent hyperparathyroidism after parathyroidectomy in tertiary hyperparathyroidism after renal transplantation. Surgery 140(6):990–997, Discussion 7–9

Wagner PK, Seesko HG, Rothmund M (1991) Replantation of cryopreserved human parathyroid tissue. World J Surg 15(6):751–755

Wells SA Jr, Ellis GJ, Gunnells JC, Schneider AB, Sherwood LM (1976) Parathyroid autotransplantation in primary parathyroid hyperplasia. N Engl J Med 295(2):57–62

Casanova D, Sarfati E, De Francisco A, Amado JA, Arias M, Dubost C (1991) Secondary hyperparathyroidism: diagnosis of site of recurrence. World J Surg 15(4):546–549, discussion 9–50

Schlosser K, Sitter H, Rothmund M, Zielke A (2004) Assessing the site of recurrence in patients with secondary hyperparathyroidism by a simplified Casanova autograftectomy test. World J Surg 28(6):583–588

Rothmund M, Wagner PK, Schark C (1991) Subtotal parathyroidectomy versus total parathyroidectomy and autotransplantation in secondary hyperparathyroidism: a randomized trial. World J Surg 15(6):745–750

Richards ML, Wormuth J, Bingener J, Sirinek K (2006) Parathyroidectomy in secondary hyperparathyroidism: Is there an optimal operative management? Surgery 139(2):174–180

Lorenz K, Sekulla C, Dralle H (2013) Chirurgisches Management des renalen Hyperparathyreoidismus. Zentralbl Chir 138(Suppl 2):e47–e54

Schneider R, Bartsch DK, Schlosser K (2013) Relevance of bilateral cervical thymectomy in patients with renal hyperparathyroidism: analysis of 161 patients undergoing reoperative parathyroidectomy. World J Surg 37(9):2155–2161

David DS, Sakai S, Brennan BL, Riggio RA, Cheigh J, Stenzel KH et al (1973) Hypercalcemia after renal transplantation. Long-term follow-up data. N Engl J Med 289(8):398–401

Geis WP, Popovtzer MM, Corman JL, Halgrimson CG, Groth CG, Starzi TE (1973) The diagnosis and treatment of hyperparathyroidism after renal homotransplantation. Surgery, Gynecology and Obstetrics 137(6):997–1010

Rostaing L, Moreau-Gaudry X, Baron E, Cisterne JM, Monrozies-Bernadet P, Durand D (1997) Changes in blood pressure and renal function following subtotal parathyroidectomy in renal transplant patients presenting with persistent hypercalcemic hyperparathyroidism. Clin Nephrol 47(4):248–255

Lee PP, Schiffmann L, Offermann G, Beige J (2004) Effects of parathyroidectomy on renal allograft survival. Kidney Blood Press Res 27(3):191–196

Evenepoel P, Claes K, Kuypers DR, Debruyne F, Vanrenterghem Y (2007) Parathyroidectomy after successful kidney transplantation: a single centre study. Nephrol Dial Transplant 22(6):1730–1737

Evenepoel P, Claes K, Kuypers D, Maes B, Vanrenterghem Y (2005) Impact of parathyroidectomy on renal graft function, blood pressure and serum lipids in kidney transplant recipients: a single centre study. Nephrol Dial Transplant 20(8):1714–1720

Massfelder T, Parekh N, Endlich K, Saussine C, Steinhausen M, Helwig JJ (1996) Effect of intrarenally infused parathyroid hormone-related protein on renal blood flow and glomerular filtration rate in the anaesthetized rat. Br J Pharmacol 118(8):1995–2000

Ogata H, Ritz E, Odoni G, Amann K, Orth SR (2003) Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors. J Am Soc Nephrol 14(4):959–967

Kerby JD, Rue LW, Blair H, Hudson S, Sellers MT, Diethelm AG (1998) Operative treatment of tertiary hyperparathyroidism: a single-center experience. Ann Surg 227(6):878–886

Schwarz A, Rustien G, Merkel S, Radermacher J, Haller H (2007) Decreased renal transplant function after parathyroidectomy. Nephrol Dial Transplant 22(2):584–591

Jeon HJ, Kim YJ, Kwon HY, Koo TY, Baek SH, Kim HJ et al (2012) Impact of parathyroidectomy on allograft outcomes in kidney transplantation. Transpl Int 25(12):1248–1256

Schlosser K, Endres N, Celik I, Fendrich V, Rothmund M, Fernandez ED (2007) Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters! World J Surg 31(10):1947–1953

Ogg CS (1967) Total parathyroidectomy in treatment of secondary (renal) hyperparathyroidism. Br Med J 4(5575):331–334

Schlosser K, Veit JA, Witte S, Fernández ED, Victor N, Knaebel H-P et al (2007) Comparison of total parathyroidectomy without autotransplantation and without thymectomy versus total parathyroidectomy with autotransplantation and with thymectomy for secondary hyperparathyroidism: TOPAR PILOT-Trial. Trials 8(1):22

Schneider R, Slater EP, Karakas E, Bartsch DK, Schlosser K (2012) Initial parathyroid surgery in 606 patients with renal hyperparathyroidism. World J Surg 36(2):318–326

Lorenz K, Ukkat J, Sekulla C, Gimm O, Brauckhoff M, Dralle H (2006) Total parathyroidectomy without autotransplantation for renal hyperparathyroidism: experience with a qPTH-controlled protocol. World J Surg 30(5):743–751

Pattou FN, Pellissier LC, Noël C, Wambergue F, Huglo DG, Proye CA (2000) Supernumerary parathyroid glands: frequency and surgical significance in treatment of renal hyperparathyroidism. World J Surg 24(11):1330–1334

Schneider R, Waldmann J, Ramaswamy A, Fernandez ED, Bartsch DK, Schlosser K (2011) Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomy. World J Surg 35(6):1260–1265

Aly A, Douglas M (2003) Embryonic parathyroid rests occur commonly and have implications in the management of secondary hyperparathyroidism. ANZ J Surg 73(5):284–288

Maxwell PH, Winearls CG (1997) Recurrence of autonomous hyperparathyroidism in dialysis patients. Nephrol Dial Transplant 12(10):2195–2200

Gaz RD, Doubler PB, Wang C (1987) The management of 50 unusual hyperfunctioning parathyroid glands. Surgery 102(6):949–957

Ockert S, Willeke F, Richter A, Jonescheit J, Schnuelle P, van der Woude F et al (2002) Total parathyroidectomy without autotransplantation as a standard procedure in the treatment of secondary hyperparathyroidism. Langenbecks Arch Surg 11387(5–6):204–209

Coulston JE, Egan R, Willis E, Morgan JD (2010) Total parathyroidectomy without autotransplantation for renal hyperparathyroidism. Br J Surg 97(11):1674–1679

Galloway PA, El-Damanawi R, Bardsley V, Pritchard NR, Fry AC, Ojha SK et al (2015) Vitamin K antagonists predispose to calciphylaxis in patients with end-stage renal disease. Nephron 129(3):197–201

Weenig RH, Sewell LD, Davis MDP, McCarthy JT, Pittelkow MR (2007) Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol 56(4):569–579

Girotto JA, Harmon JW, Ratner LE, Nicol TL, Wong L, Chen H (2001) Parathyroidectomy promotes wound healing and prolongs survival in patients with calciphylaxis from secondary hyperparathyroidism. Surgery 130(4):645–650, discussion 50–1

Duh Q, Lim RC, Clark OH (1991) Calciphylaxis in secondary hyperparathyroidism: diagnosis and parathyroidectomy. Arch Surg 126(10):1213–1219

Kang AS, McCarthy JT, Rowland C, Farley DR, Van Heerden JA (2000) Is calciphylaxis best treated surgically or medically? Surgery 128(6):967–972

Caccitolo JA, Farley DR, van Heerden JA, Grant CS, Thompson GB, Sterioff S (1997) The current role of parathyroid cryopreservation and autotransplantation in parathyroid surgery: an institutional experience. Surgery 122(6):1062–1067

Saxe AW, Spiegel AM, Marx SJ, Brennan MF (1982) Deferred parathyroid autografts with cryopreserved tissue after reoperative parathyroid surgery. Arch Surg 117(5):538–543

Feldman AL, Sharaf RN, Skarulis MC, Bartlett DL, Libutti SK, Weinstein LS et al (1999) Results of heterotopic parathyroid autotransplantation: a 13-year experience. Surgery 126(6):1042–1048

Borot S, Lapierre V, Carnaille B, Goudet P, Penfornis A (2010) Results of cryopreserved parathyroid autografts: a retrospective multicenter study. Surgery 147(4):529–535

Tominaga Y (2006) Surgical treatment of secondary hyperparathyroidism due to chronic kidney disease. Ups J Med Sci 111(3):277–292

Cohen MS, Dilley WG, Wells SA, Moley JF, Doherty GM, Sicard GA et al (2005) Long-term functionality of cryopreserved parathyroid autografts: a 13-year prospective analysis. Surgery 138(6):1033–1041

Agarwal A, Waghray A, Gupta S, Sharma R, Milas M (2013) Cryopreservation of parathyroid tissue: an illustrated technique using the Cleveland clinic protocol. J Am Coll Surg 216(1):e1–e9

Guerrero MA, Evans DB, Lee JE, Bao R, Bereket A, Gantela S et al (2008) Viability of cryopreserved parathyroid tissue: when is continued storage versus disposal indicated? World J Surg 32(5):836–839

Yoo J, Young JEM (2012) Secondary hyperparathyroidism: surgical. In: Khan AA, Clark OH (eds) Handbook of parathyroid diseases, 1st edn. Springer, New York, pp 159–180

Lokey J, Pattou F, Mondragon-Sanchez A, Minuto M, Mullineris B, Wambergue F et al (2000) Intraoperative decay profile of intact (1–84) parathyroid hormone in surgery for renal hyperparathyroidism—a consecutive series of 80 patients. Surgery 128(6):1029–1034

Barczyński M, Cichoń S, Konturek A, Cichoń W (2005) A randomised study on a new cost-effective algorithm of quick intraoperative intact parathyroid hormone assay in secondary hyperparathyroidism. Langenbecks Arch Surg 390(2):121–127

Seehofer D, Rayes N, Klupp J, Steinmüller T, Ulrich F, Müller C et al (2005) Predictive value of intact parathyroid hormone measurement during surgery for renal hyperparathyroidism. Langenbecks Arch Surg 390(3):222–229

Weber T, Zeier M, Hinz U, Schilling T, Büchler MW (2005) Impact of intraoperative parathyroid hormone levels on surgical results in patients with renal hyperparathyroidism. World J Surg 29(9):1176–1179

Pitt SC, Panneerselvan R, Chen H, Sippel RS (2010) Secondary and tertiary hyperparathyroidism: the utility of ioPTH monitoring. World J Surg 34(6):1343–1349

Roshan A, Kamath B, Roberts S, Atkin S, England R (2006) Intra-operative parathyroid hormone monitoring in secondary hyperparathyroidism: is it useful? Clin Otolaryngol 31(3):198–203

Moor JW, Roberts S, Atkin SL, England RJ (2011) Intraoperative parathyroid hormone monitoring to determine long-term success of total parathyroidectomy for secondary hyperparathyroidism. Head Neck 33(3):293–296

Muller-Stich BP, Brandle M, Binet I, Warschkow R, Lange J, Clerici T (2007) To autotransplant simultaneously or not–can intraoperative parathyroid hormone monitoring reliably predict early postoperative parathyroid hormone levels after total parathyroidectomy for hyperplasia? Surgery 142(1):47–56

Freriks K, Hermus AR, de Sévaux RG, Bonenkamp HJ, Biert J, den Heijer M et al (2010) Usefulness of intraoperative parathyroid hormone measurements in patients with renal hyperparathyroidism. Head Neck 32(10):1328–1335

Yamashita H, Cantor T, Uchino S, Watanabe S, Ogawa T, Moriyama T et al (2005) Sequential changes in plasma intact and whole parathyroid hormone levels during parathyroidectomy for secondary hyperparathyroidism. World J Surg 29(2):169–173

Bieglmayer C, Kaczirek K, Prager G, Niederle B (2006) Parathyroid hormone monitoring during total parathyroidectomy for renal hyperparathyroidism: pilot study of the impact of renal function and assay specificity. Clin Chem 52(6):1112–1119

Tominaga Y, Uchida K, Haba T, Katayama A, Sato T, Hibi Y et al (2001) More than 1,000 cases of total parathyroidectomy with forearm autograft for renal hyperparathyroidism. Am J Kidney Dis 38(4):S168–S171

Kestenbaum B, Andress DL, Schwartz SM, Gillen DL, Seliger SL, Jadav PR et al (2004) Survival following parathyroidectomy among United States dialysis patients. Kidney Int 66(5):2010–2016

Conzo G, Perna AF, Savica V, Palazzo A, Pietra CD, Ingrosso D et al (2013) Impact of parathyroidectomy on cardiovascular outcomes and survival in chronic hemodialysis patients with secondary hyperparathyroidism. A retrospective study of 50 cases prior to the calcimimetics era. BMC Surg 13(Suppl 2):S4

Costa-Hong V, Jorgetti V, Gowdak LHW, Moyses RMA, Krieger EM, De Lima JJG (2007) Parathyroidectomy reduces cardiovascular events and mortality in renal hyperparathyroidism. Surgery 142(5):699–703

Cheng SP, Liu CL, Chen HH, Lee JJ, Liu TP, Yang TL (2009) Prolonged hospital stay after parathyroidectomy for secondary hyperparathyroidism. World J Surg 33(1):72–79

Ureña P, Kubrusly M, Mannstadt M, Sarfati E, Drueke T (1994) Total or subtotal parathyroidectomy in uremic patients? Clin Nephrol 41(1):59–60

Sitges-Serra A, Caralps-Riera A (1987) Hyperparathyroidism associated with renal disease. Pathogenesis, natural history, and surgical treatment. Surg Clin North Am 67(2):359–377

Florescu MC, Islam KM, Plumb TJ, Smith-Shull S, Nieman J, Mandalapu P (2014) Calcium supplementation after parathyroidectomy in dialysis and renal transplant patients. Int J Nephrol Renovasc Dis 7:183–190

Latus J, Roesel M, Fritz P, Braun N, Ulmer C, Steurer W et al (2013) Incidence of and risk factors for hungry bone syndrome in 84 patients with secondary hyperparathyroidism. Int J Nephrol Renovasc Dis 6:131–137

Torer N, Torun D, Micozkadioglu H, Noyan T, Ozdemir FN, Haberal M (2009) Predictors of early postoperative hypocalcemia in hemodialysis patients with secondary hyperparathyroidism. In: Transplantation Proceedings. Elsevier, Amsterdam

Niramitmahapanya S, Sunthornthepvarakul T, Deerochanawong C, Sarinnapakorn V, Athipan P (2011) Role of loading calcitriol to control hypocalcemia after parathyroidectomy in chronic kidney disease. J Med Assoc Thai 94(3):295

Goh BL, Yudisthra MG, Hisham AN (2010) Alkaline phosphatase predicts calcium requirements after total parathyroidectomy in patients receiving dialysis. Br J Surg 97(2):185–188

Kievit A, Tinnemans J, Idu M, Groothoff J, Surachno S, Aronson D (2010) Outcome of total parathyroidectomy and autotransplantation as treatment of secondary and tertiary hyperparathyroidism in children and adults. World J Surg 34(5):993–1000

Mozes MF, Soper WD, Jonasson O, Lang GR (1980) Total parathyroidectomy and autotransplantation in secondary hyperparathyroidism. Arch Surg 115(4):378–385

Triponez F, Evenepoel P (2012) Pathophysiology and treatment of secondary and tertiary hyperparathyroidism. In: Oertli D, Udelsman R (eds) Surgery of the thyroid and parathyroid glands. Springer, Berlin Heidelberg, pp 517–536

Dewberry LC, Tata S, Graves S, Weber CJ, Sharma J (2014) Predictors of tertiary hyperparathyroidism: Who will benefit from parathyroidectomy? Surgery 156(6):1631–1637

Messa P, Cafforio C, Alfieri C (2011) Clinical impact of hypercalcemia in kidney transplant. International Journal of Nephrology 2011:906832

Jamal SA, Miller PD (2013) Secondary and tertiary hyperparathyroidism. J Clin Densitom 16(1):64–68

Evenepoel P, Claes K, Kuypers D, Maes B, Bammens B, Vanrenterghem Y (2004) Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study. Nephrol Dial Transplant 19(5):1281–1287

Kuo LE, Wachtel H, Karakousis G, Fraker D, Kelz R (2014) Parathyroidectomy in dialysis patients. J Surg Res 190(2):554–558

Gupta PK, Smith RB, Gupta H, Forse RA, Fang X, Lydiatt WM (2012) Outcomes after thyroidectomy and parathyroidectomy. Head Neck 34(4):477–484

Torregrosa JV, Barros X (2013) Management of hypercalcemia after renal transplantation. Nefrologia 33(6):751–757

Yamada S, Tokumoto M, Taniguchi M, Toyonaga J, Suehiro T, Eriguchi R, et al. (2015) Two years of cinacalcet hydrochloride treatment decreased parathyroid gland volume and serum parathyroid hormone level in hemodialysis patients with advanced secondary hyperparathyroidism. Therapeutic Apheresis and Dialysis

Somnay YR, Weinlander E, Schneider DF, Sippel RS, Chen H (2014) The effect of cinacalcet on intraoperative findings in tertiary hyperparathyroidism patients undergoing parathyroidectomy. Surgery 156(6):1308–1314

Evenepoel P, Van Den Bergh B, Naesens M, De Jonge H, Bammens B, Claes K et al (2009) Calcium metabolism in the early posttransplantation period. Clin J Am Soc Nephrol 4(3):665–672

Triponez F, Clark OH, Vanrenthergem Y, Evenepoel P (2008) Surgical treatment of persistent hyperparathyroidism after renal transplantation. Ann Surg 248(1):18–30

Tominaga Y, Numano M, Tanaka Y, Uchida K, Takagi H, editors. Surgical treatment of renal hyperparathyroidism. Seminars in Surgical Oncology; 1997: Wiley.

Tominaga Y, Tanaka Y, Sato K, Nagasaka T, Takagi H (1997) Histopathology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism. Semin Surg Oncol 13(2):78–86

Fukagawa M, Kitaoka M, Yi H, Fukuda N, Matsumoto T, Ogata E et al (1994) Serial evaluation of parathyroid size by ultrasonography is another useful marker for the long-term prognosis of calcitriol pulse therapy in chronic dialysis patients. Nephron 68(2):221–228

Bonarek H, Merville P, Bonarek M, Moreau K, Morel D, Aparicio M et al (1999) Reduced parathyroid functional mass after successful kidney transplantation. Kidney Int 56(2):642–649

Muirhead N, Zaltman J, Gill J, Churchill D, Poulin-Costello M, Mann V et al (2014) Hypercalcemia in renal transplant patients: prevalence and management in Canadian transplant practice. Clin Transplant 28(2):161–165

Reinhardt W, Bartelworth H, Jockenhövel F, Schmidt-Gayk H, Witzke O, Wagner K et al (1998) Sequential changes of biochemical bone parameters after kidney transplantation. Nephrol Dial Transplant 13(2):436–442

Heaf J, Tvedegaard E, Kanstrup IL, Fogh-Andersen N (2000) Bone loss after renal transplantation: role of hyperparathyroidism, acidosis, cyclosporine and systemic disease. Clin Transplant 14(5):457–463

Ozdemir F, Afsar B, Akgul A, Usluoğulları C, Akçay A, Haberal M (2006) Persistent hypercalcemia is a significant risk factor for graft dysfunction in renal transplantation recipients. Transplant Proc 38(2):480–482

Messa P, Sindici C, Cannella G, Miotti V, Risaliti A, Gropuzzo M et al (1998) Persistent secondary hyperparathyroidism after renal transplantation. Kidney Int 54(5):1704–1713

Torres A, Lorenzo V, Salido E (2002) Calcium metabolism and skeletal problems after transplantation. J Am Soc Nephrol 13(2):551–558

Shen WT, Kebebew E, Suh I, Duh QY, Clark OH (2009) Two hundred and two consecutive operations for secondary hyperparathyroidism: has medical management changed the profiles of patients requiring parathyroidectomy? Surgery 146(2):296–299

Ferreira GF, Montenegro FLM, Machado DJ, Ianhez LE, Nahas WC, David-Neto E (2011) Parathyroidectomy after kidney transplantation: short-and long-term impact on renal function. Clinics (Sao Paulo) 66(3):431–435

Park JH, Kang S-W, Jeong JJ, Nam K-H, Chang HS, Chung WY et al (2011) Surgical treatment of tertiary hyperparathyroidism after renal transplantation: a 31-year experience in a single institution. Endocr J 58(10):827–833

Parikh S, Nagaraja H, Agarwal A, Samavedi S, Visger J, Nori U et al (2013) Impact of post-kidney transplant parathyroidectomy on allograft function. Clin Transplant 27(3):397–402

Pinheiro HS, Câmara NOS, Osaki KS, De Moura LAR, Pacheco-Silva A (2005) Early presence of calcium oxalate deposition in kidney graft biopsies is associated with poor long-term graft survival. Am J Transplant 5(2):323–329

Meola M, Petrucci I, Barsotti G (2009) Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism. Nephrol Dial Transplant 24(3):982–989

Komaba H, Nakanishi S, Fujimori A, Tanaka M, Shin J, Shibuya K et al (2010) Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidism. Clin J Am Soc Nephrol 5(12):2305–2314

Yuan CM, Nee R, Narayan R, Abbott KC (2012) Treatment of secondary hyperparathyroidism with parathyroidectomy instead of cinacalcet: time to pick the low-hanging fruit? Am J Kidney Dis 60(2):179–181

Kandil E, Florman S, Alabbas H, Abdullah O, McGee J, Noureldine S et al (2010) Exploring the effect of parathyroidectomy for tertiary hyperparathyroidism after kidney transplantation. Am J Med Sci 339(5):420–424

Copley JB, Wüthrich RP (2011) Therapeutic management of post-kidney transplant hyperparathyroidism. Clin Transplant 25(1):24–39

Rayes N, Seehofer D, Schindler R et al (2008) Long-term results of subtotal vs total parathyroidectomy without autotransplantation in kidney transplant recipients. Arch Surg 143(8):756–761

Sadideen HM, Taylor JD, Goldsmith DJ (2012) Total parathyroidectomy without autotransplantation after renal transplantation for tertiary hyperparathyroidism: long-term follow-up. Int Urol Nephrol 44(1):275–281

Drakopoulos S, Koukoulaki M, Apostolou T et al (2009) Total parathyroidectomy without autotransplantation in dialysis patients and renal transplant recipients, long-term follow-up evaluation. Am J Surg 198(2):178–183

Tseng PY, Yang WC, Yang CY et al (2015) Long-term Outcomes of Parathyroidectomy in Kidney Transplant Recipients with Persistent Hyperparathyroidism. Kidney Blood Press Res 40(4):386–394

Pitt SC, Panneerselvan R, Chen H et al (2009) Tertiary hyperparathyroidism: is less than a subtotal resection ever appropriate? A study of long-term outcomes. Surgery 146(6):1130–1137