Thijs Jansen1, J.H.A.M. Kaanders2, Guus N. Beute3, Henri Timmers4, Henri A. M. Marres1, Henricus P. M. Kunst1,5
1Department of otolaryngology and Head & Neck surgery Radboudumc Nijmegen The Netherlands
2Department of Radiation Oncology Radboudumc, Nijmegen, The Netherlands
3Department of Neurosurgery, St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands
4Department of Endocrinology, Radboudumc, Nijmegen, The Netherlands
5Department of otology and Head & Neck Surgery MUMC+Maastricht the Netherlands
Tóm tắt
ObjectivesTo identify the risks associated with surgery, radiotherapy or a combined treatment approach for Fisch class C and D jugulotympanic paraganglioma, in order to develop an individualised approach for each patient depending on Fisch class, age, mutation presence, tumour size growth rate and presenting symptoms.DesignA retrospective multicenter cohort study with all patient records of patients with a head and neck paraganglioma in the Radboudumc, Nijmegen and the St. Elisabeth Hospital, Tilburg, the Netherlands.Main outcome measuresLocal control, cranial nerve damage, complications, function recovery.ResultsWe found highest local control rates after tumour debulking with postoperative radiotherapy in case of residual tumour growth, referred to as the combined treatment group, (100%; n = 19), which was significantly higher than the surgical group (82%; n = 17; P = 0.00), but did not differ from the radiotherapy group (90%; n = 29). There were significantly less complications in the radiotherapy group, when compared to surgery (63 vs 27%; P = 0.002) and the combined group (44 vs 27%; P = 0.016). Furthermore,: using a logistic regression model, we found that pretreatment tumour growth was a negative predictor for post‐treatment cranial nerve function recovery (OR = 50.178, P = 0.001), reducing the chance of symptom recovery (67.3% vs 35.7%) post‐treatment.ConclusionsRadiotherapy should be the treatment of choice for the elderly. For younger patients, tumour debulking should be considered, with potential radiotherapy in case of residual tumour growth.
