Supraspinal neuroimmune crosstalk in chronic pain states

Kendroud, 2018, Physiology, nociceptive pathways Todd, 2010, Neuronal circuitry for pain processing in the dorsal horn, Nat Rev Neurosci, 11, 823, 10.1038/nrn2947 Fiore, 2016, Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?, Brain Behav Immun, 56, 397, 10.1016/j.bbi.2016.04.012 Louveau, 2017, Understanding the functions and relationships of the glymphatic system and meningeal lymphatics, J Clin Invest, 127, 3210, 10.1172/JCI90603 Dantzer, 2018, Neuroimmune interactions: from the brain to the immune system and vice versa, Physiol Rev, 98, 477, 10.1152/physrev.00039.2016 Langjahr, 2018, Increased pro-inflammatory cytokine gene expression in peripheral blood mononuclear cells of patients with polyneuropathies, J Neurol, 265, 618, 10.1007/s00415-018-8748-4 Uceyler, 2007, Differential expression of cytokines in painful and painless neuropathies, Neurology, 69, 42, 10.1212/01.wnl.0000265062.92340.a5 Palada, 2019, Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease, Brain Behav Immun, 75, 60, 10.1016/j.bbi.2018.09.010 Russo, 2019, Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome, J Neuroinflammation, 16, 63, 10.1186/s12974-019-1449-9 Austin, 2010, The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines, J Neuroimmunol, 229, 26, 10.1016/j.jneuroim.2010.08.013 Grace, 2014, Pathological pain and the neuroimmune interface, Nat Rev Immunol, 14, 217, 10.1038/nri3621 Sawada, 2014, Suppression of bone marrow-derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice, Pain, 155, 1762, 10.1016/j.pain.2014.05.031 LeBlanc, 2011, Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy, Neurosci Lett, 498, 138, 10.1016/j.neulet.2011.04.077 Taylor, 2017, Topography of microglial activation in sensory- and affect-related brain regions in chronic pain, J Neurosci Res, 95, 1330, 10.1002/jnr.23883 Kim, 2016, Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain, J Clin Invest, 126, 1983, 10.1172/JCI82859 Chamaa, 2016, Transcriptional expression of inflammatory mediators in various somatosensory relay centers in the brain of rat models of peripheral mononeuropathy and local inflammation, J Neuroimmunol, 297, 81, 10.1016/j.jneuroim.2016.05.005 Banati, 2001, Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury, Neuroreport, 12, 3439, 10.1097/00001756-200111160-00012 Albrecht, 2018, Brain glial activation in fibromyalgia — a multi-site positron emission tomography investigation, Brain Behav Immun, 75, 72, 10.1016/j.bbi.2018.09.018 Loggia, 2015, Evidence for brain glial activation in chronic pain patients, Brain, 138, 604, 10.1093/brain/awu377 Alshelh, 2018, Altered regional brain T2 relaxation times in individuals with chronic orofacial neuropathic pain, Neuroimage Clin, 19, 167, 10.1016/j.nicl.2018.04.015 Alshelh, 2016, Chronic neuropathic pain: it’s about the rhythm, J Neurosci, 36, 1008, 10.1523/JNEUROSCI.2768-15.2016 Shi, 2012, Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients, J Neurosci, 32, 10833, 10.1523/JNEUROSCI.5628-11.2012 Gui, 2016, Interleukin-1beta overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents, Mol Pain, 12, 10.1177/1744806916646784 Fiore, 2018, Glial-cytokine-neuronal adaptations in the ventral hippocampus of rats with affective behavioral changes following peripheral nerve injury, Neuroscience, 390, 119, 10.1016/j.neuroscience.2018.08.010 Mor, 2010, Anatomically specific patterns of glial activation in the periaqueductal gray of the subpopulation of rats showing pain and disability following chronic constriction injury of the sciatic nerve, Neuroscience, 166, 1167, 10.1016/j.neuroscience.2010.01.045 Austin, 2015, Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury, J Neuroinflamm, 12, 96, 10.1186/s12974-015-0318-4 Fang, 2018, Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury, Eur Arch Psychiatry Clin Neurosci, 10.1007/s00406-018-0909-z Li, 2018, Role of Keap1-Nrf2 signaling in anhedonia symptoms in a rat model of chronic neuropathic pain: improvement with sulforaphane, Front Pharmacol, 9, 887, 10.3389/fphar.2018.00887 Xie, 2017, Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine, Sci Rep, 7 Xu, 2017, Spared nerve injury increases the expression of microglia M1 markers in the prefrontal cortex of rats and provokes depression-like behaviors, Front Neurosci, 11, 209, 10.3389/fnins.2017.00209 Monassi, 2003, A subpopulation of rats show social and sleep-waking changes typical of chronic neuropathic pain following peripheral nerve injury, Eur J Neurosci, 17, 1907, 10.1046/j.1460-9568.2003.02627.x Chu Sin Chung, 2017, Peripheral nerve injury induces a transitory microglial reaction in the rat infralimbic cortex, Neurosci Lett, 655, 14, 10.1016/j.neulet.2017.06.037 Liu, 2017, TNF-alpha differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury, J Neurosci, 37, 871, 10.1523/JNEUROSCI.2235-16.2016 Tyrtyshnaia, 2017, Adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment, Acta Histochem, 119, 812, 10.1016/j.acthis.2017.10.007 Keay, 2008, 5.42 - emotional and behavioral significance of the pain signal and the role of the midbrain periaqueductal gray (PAG), 627 Ni, 2016, Glial activation in the periaqueductal gray promotes descending facilitation of neuropathic pain through the p38 MAPK signaling pathway, J Neurosci Res, 94, 50, 10.1002/jnr.23672 Ni, 2019, Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation, J Neuroinflamm, 16, 1, 10.1186/s12974-018-1391-2 Ossipov, 2014, Descending pain modulation and chronification of pain, Curr Opin Support Palliat Care, 8, 143, 10.1097/SPC.0000000000000055 Guo, 2012, Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation, Neurosci Bull, 28, 193, 10.1007/s12264-012-1218-6 Guo, 2017, In vivo immune interactions of multipotent stromal cells underlie their long-lasting pain-relieving effect, Sci Rep, 7 Guo, 2018, NF-kappaB pathway is involved in bone marrow stromal cell-produced pain relief, Front Integr Neurosci, 12, 49, 10.3389/fnint.2018.00049 Rosenblat, 2018, Efficacy and tolerability of minocycline for depression: a systematic review and meta-analysis of clinical trials, J Affect Disord, 227, 219, 10.1016/j.jad.2017.10.042 Raison, 2013, A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers, JAMA Psychiatry, 70, 31, 10.1001/2013.jamapsychiatry.4 Goehler, 1999, Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?, J Neurosci, 19, 2799, 10.1523/JNEUROSCI.19-07-02799.1999 Quan, 2007, Brain-immune communication pathways, Brain Behav Immun, 21, 727, 10.1016/j.bbi.2007.05.005 D’Mello, 2013, P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors, J Neurosci, 33, 14878, 10.1523/JNEUROSCI.1329-13.2013 Mitchell, 2009, Monocyte chemoattractant protein-1 in the choroid plexus: a potential link between vascular pro-inflammatory mediators and the CNS during peripheral tissue inflammation, Neuroscience, 158, 885, 10.1016/j.neuroscience.2008.10.047 Iliff, 2012, A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta, Sci Transl Med, 4, 10.1126/scitranslmed.3003748 Louveau, 2015, Structural and functional features of central nervous system lymphatic vessels, Nature, 523, 337, 10.1038/nature14432 Ren, 2011, Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-alpha in rodents, Neuropsychopharmacology, 36, 979, 10.1038/npp.2010.236 Wang, 2013, Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-alpha, Pain Physician, 16, E563 Kim, 2012, Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression, J Clin Invest, 122, 2940, 10.1172/JCI61884 Walker, 2013, NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice, Neuropsychopharmacology, 38, 1609, 10.1038/npp.2013.71 Zhou, 2015, Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice, Brain Behav Immun, 46, 147, 10.1016/j.bbi.2015.01.013 Dellarole, 2014, Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling, Brain Behav Immun, 41, 65, 10.1016/j.bbi.2014.04.003 Covey, 2000, Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain, Brain Res, 859, 113, 10.1016/S0006-8993(00)01965-X Pellegrino, 2011, Cytokines inhibit norepinephrine transporter expression by decreasing Hand2, Mol Cell Neurosci, 46, 671, 10.1016/j.mcn.2011.01.008 Zhu, 2010, Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters, Neuropsychopharmacology, 35, 2510, 10.1038/npp.2010.116 Pace, 2009, Cytokines and glucocorticoid receptor signaling. Relevance to major depression, Ann N Y Acad Sci, 1179, 86, 10.1111/j.1749-6632.2009.04984.x