Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin

Cohn, L., L. Whittaker, N. Niu, and R.J. Homer. 2002. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Foundation Symposium 248: 201–213.

Fischer, B.M., L.G. Rochelle, J.A. Voynow, N.J. Akley, and K.B. Adler. 1999. TNF-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. American Journal of Respiratory Cell and Molecular Biology 20: 413–422.

Gomita, Y., Y. Ichimaru, M. Moriyama, K. Fukamachi, A. Uchikado, Y. Araki, T. Fukuda, and T. Koyama. 1981. Behavioral and EEG effects of coixol (6-methoxybenzoxazolone), one of the components in Coix Lachryma-Jobi L. var. ma-yuen Stapf. Nihon Shinkei Seishin Yakuri Gakkai 77(3): 245–259.

Heo, H.J., C. Kim, H.J. Lee, Y.S. Kim, S.S. Kang, U.K. Seo, Y.H. Kim, Y.C. Park, J.H. Seok, and C.J. Lee. 2007. Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells. Phytotherapy Research 21(5): 462–465.

Heo, H.J., S.Y. Lee, M.N. Lee, H.J. Lee, J.H. Seok, and C.J. Lee. 2009. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytotherapy Research 23(10): 1458–1461.

Hewson, C.A., M.R. Edbrooke, and S.L. Johnston. 2004. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells via PKC, EGF/TGF-alpha, Ras/Raf, MEK, REK and Sp1-dependent mechanisms. Journal of Molecular Biology 344: 683–695.

Hong, D.H., G. Petrovics, W.B. Anderson, J. Forstner, and G. Forstner. 1999. Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-epsilon. American Journal of Physiology 277: G1041–G1047.

Jang, I.M. 2003. Treatise on Asian herbal medicines. Seoul: Haksul-pyunsu-kwan in Research institute of natural products of Seoul National University.

Lee, C.J., S.H. Paik, K.H. Ko, and K.C. Kim. 2002. Effects of polycationic peptides on mucin release from airway goblet cells: relationship between polymer size and activity. Inflammation Research 51(10): 490–494.

Lee, H.J., S.Y. Lee, M.N. Lee, J.H. Kim, G.T. Chang, J.H. Seok, and C.J. Lee. 2011. Inhibition of secretion, production and gene expression of mucin from cultured airway epithelial cells by prunetin. Phytotherapy Research 25: 1196–1200.

Li, J.D., A.F. Dohrman, M. Gallup, S. Miyata, J.R. Gum, Y.S. Kim, J.A. Nadel, A. Prince, and C.B. Basbaum. 1997. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proceedings of the National Academy of Sciences of the United States of America 94(3): 967–972.

Park, S.J., S.Y. Kang, N.S. Kim, and H.M. Kim. 2002. Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60cells. Immunopharmacology and Immunotoxicology 24(2): 211–226.

Rogers, D.F., and P.J. Barnes. 2006. Treatment of airway mucus hypersecretion. Annals of Medicine 38(2): 116–125.

Shao, M.X., I.F. Ueki, and J.A. Nadel. 2003. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 100: 11618–11623.

Song, K., W.J. Lee, K.C. Chung, J.S. Koo, E.J. Yang, J.Y. Choi, and J.H. Yoon. 2003. Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen activated protein kinases-MSK1-CREB activation in human airway epithelial cells. Journal of Biological Chemistry 278: 23243–23250.

Takeyama, K., K. Dabbagh, H.M. Lee, C. Agustí, J.A. Lausier, I.F. Ueki, K.M. Grattan, and J.A. Nadel. 1999. Epidermal growth factor system regulates mucin production in airways. Proceedings of the National Academy of Sciences of the United States of America 96: 3081–3086.

Takeyama, K., K. Dabbagh, J.J. Shim, T. Dao-Pick, I.F. Ueki, and J.A. Nadel. 2000. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. Journal of Immunology 164(3): 1546–1552.

Voynow, J.A., and B.K. Rubin. 2009. Mucins, mucus, and sputum. Chest 135(2): 505–512.

Wang, H.X., F. Liu, and T.B. Ng. 2001. Examination of pineal indoles and 6-methoxy-2-benzoxazolinone for antioxidant and antimicrobial effects. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 130(3): 379–388.

Wang, H.X., and T.B. Ng. 2002. Demonstration of antifungal and anti-human immunodeficiency virus reverse transcriptase activities of 6-methoxy-2-benzoxazolinone and antibacterial activity of the pineal indole 5-methoxyindole-3-acetic acid. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 132(2): 261–268.