Suppression of human macrophage-mediated cytotoxicity by transgenic swine endothelial cell expression of HLA-G

Miyagawa, 1988, The mechanism of discordant xenograft rejection, Transplantation, 46, 825, 10.1097/00007890-198812000-00007 Miyagawa, 2010, Complement regulation in the GalT KO era, Xenotransplantation, 17, 11, 10.1111/j.1399-3089.2010.00569.x Ekser, 2009, Xenotransplantation of solid organs in the pig-to-primate model, Transpl Immunol, 21, 87, 10.1016/j.trim.2008.10.005 Mohiuddin, 2014, Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation, J Thorac Cardiovasc Surg, 148, 1106, 10.1016/j.jtcvs.2014.06.002 Matsunami, 2001, The possible use of HLA-G1 and G3 in the inhibition of NK cell-mediated swine endothelial cell lysis, Clin Exp Immunol, 126, 165, 10.1046/j.1365-2249.2001.01622.x Matsunami, 2002, Modulation of the leader peptide sequence of the HLA-E gene up-regulates its expression and dowanregulates natural killer cell-mediated swine endothelial cell lysis, Transplantation, 73, 1582, 10.1097/00007890-200205270-00010 Miyagawa, 2003, Co-effect of HLA-G1 and glycosyltransferases in reducing NK cell-mediated pig endothelial cell lysis, Transpl Immunol, 11, 147, 10.1016/S0966-3274(02)00151-X Maeda, 2013, The suppression of inflammatory macrophage-mediated cytotoxicity and proinflammatory cytokine production by transgenic expression of HLA-E, Transpl Immunol, 29, 76, 10.1016/j.trim.2013.08.001 Miyagawa, 1994, Effects of transfected complement regulatory proteins, MCP, DAF, MCP/DAF hybrid, on complement-mediated swine endothelial cell lysis, Transplantation, 58, 834, 10.1097/00007890-199410000-00015 Matsunami, 2006, Involvement of position-147 for HLA-E expression, Biochem Biophys Res Commun, 347, 692, 10.1016/j.bbrc.2006.06.146 Apps, 2007, A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1, Eur J Immunol, 37, 1924, 10.1002/eji.200737089 Shiroishi, 2006, Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d), Proc Natl Acad Sci U S A, 103, 16412, 10.1073/pnas.0605228103 Shiroishi, 2003, Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G, Proc Natl Acad Sci U S A, 100, 8856, 10.1073/pnas.1431057100 Kovats, 1990, A class I antigen, HLA-G, expressed in human trophoblasts, Science, 248, 220, 10.1126/science.2326636 Ishitani, 1992, Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens, Proc Natl Acad Sci U S A, 89, 3947, 10.1073/pnas.89.9.3947 McMaster, 1995, Human placental HLA-G expression is restricted to differentiated cytotrophoblasts, J Immunol, 154, 3771, 10.4049/jimmunol.154.8.3771 Howangyin, 2012, Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors, Cell Mol Life Sci, 69, 4041, 10.1007/s00018-012-1069-3 LeMaoult, 2013, Synthetic HLA-G proteins for therapeutic use in transplantation, FASEB J, 27, 3643, 10.1096/fj.13-228247 Naji, 2013, Concise review: combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy, Stem Cells, 31, 2296, 10.1002/stem.1494 Braud, 1998, HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C, Nature, 391, 795, 10.1038/35869 Ide, 2007, Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages, Proc Natl Acad Sci U S A, 104, 5062, 10.1073/pnas.0609661104 Weiss, 2009, HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity, Transplantation, 87, 35, 10.1097/TP.0b013e318191c784 Pazmany, 1996, Protection from natural killer cell-mediated lysis by HLA-G expression on target cells, Science, 274, 792, 10.1126/science.274.5288.792 Rouas, 1997, The alpha1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?, Proc Natl Acad Sci U S A, 94, 5249, 10.1073/pnas.94.10.5249 Sasaki, 1999, HLA-G expression protects porcine endothelial cells against natural killer cell-mediated xenogenic cytotoxicity, Transplantation, 67, 31, 10.1097/00007890-199901150-00005