Suppression of C/EBPα and Induction of C/EBPβ by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Adipose Tissue and Liver

Poland, 1982, Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons, Annu Rev Pharmacol, 22, 517, 10.1146/annurev.pa.22.040182.002505 Hankinson, 1995, The aryl hydrocarbon receptor complex, Annu Rev Pharmacol, 35, 307, 10.1146/annurev.pa.35.040195.001515 Enan, 1992, 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes reduction of glucose transporting activities in the plasma membranes of adipose tissue and pancreas from the guinea pig, J Biol Chem, 267, 19785, 10.1016/S0021-9258(19)88622-2 Liu, 1995, Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the “adipose-type” and “brain-type” glucose transporters in mice, Mol Pharmacol, 47, 65 Brewster, 1988, Reduction of adipose tissue lipoprotein lipase activity as a result of in vivo administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the guinea pig, Biochem Pharmacol, 37, 2247, 10.1016/0006-2952(88)90588-6 Lakshman, 1989, Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid synthesis and lipogenic enzymes in the rat, J Pharmacol Exp Ther, 248, 62 Landschulz, 1988, Isolation of a recombinant copy of the gene encoding C/EBP, Genes Dev, 2, 786, 10.1101/gad.2.7.786 McKnight, 1989, Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?, Genes Dev, 3, 2021, 10.1101/gad.3.12b.2021 Christy, 1989, Differentiation-induced gene expression in 3T3-L1 preadipocytes, Genes Dev, 3, 1323, 10.1101/gad.3.9.1323 Kaestner, 1990, Mouse insulin-responsive glucose transporter gene, Proc Natl Acad Sci USA, 87, 251, 10.1073/pnas.87.1.251 Tae, 1994, Roles of CCAAT/enhancer-binding protein and its binding site on repression and derepression of acetyl-CoA carboxylase gene, J Biol Chem, 269, 10475, 10.1016/S0021-9258(17)34084-X Birkenmeier, 1989, Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein, Genes Dev, 3, 1146, 10.1101/gad.3.8.1146 Wang, 1995, Impaired energy homeostasis in C/EBPα knockout mice, Science, 269, 1108, 10.1126/science.7652557 Cao, 1991, Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells, Genes Dev, 5, 1538, 10.1101/gad.5.9.1538 Akira, 1990, A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family, EMBO J, 9, 1897, 10.1002/j.1460-2075.1990.tb08316.x Chang, 1990, Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family, Mol Cell Biol, 10, 6642, 10.1128/MCB.10.12.6642 Descombes, 1990, LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein, Genes Dev, 4, 1541, 10.1101/gad.4.9.1541 Poli, 1990, IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP, Cell, 63, 643, 10.1016/0092-8674(90)90459-R Williams, 1991, A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro, Genes Dev, 5, 1553, 10.1101/gad.5.9.1553 Ron, 1992, CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription, Genes Dev, 6, 439, 10.1101/gad.6.3.439 Darlington, 1995, C/EBP alpha, Curr Opin Genet Dev, 5, 565, 10.1016/0959-437X(95)80024-7 Alam, 1992, Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response, J Biol Chem, 267, 5021, 10.1016/S0021-9258(18)42720-2 Sylvester, 1994, Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression, J Biol Chem, 269, 20119, 10.1016/S0021-9258(17)32135-X Liu, 1996, Alteration by 2,3,7,8-tetrachlorodibenzo-p-dioxin of CCAAT/enhancer binding protein correlates with suppression of adipocyte differentiation in 3T3-L1 cells, Mol Pharmacol, 49, 989 Kimura, 1984, The murine Ah locus, J Biol Chem, 259, 10705, 10.1016/S0021-9258(18)90569-7 Hattori, 1990, A simplified method for the preparation of transcriptionally active liver nuclear extracts, DNA Cell Biol, 9, 777, 10.1089/dna.1990.9.777 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 Christy, 1991, CCAAT/enhancer binding protein gene promoter, Proc Natl Acad Sci USA, 88, 2593, 10.1073/pnas.88.6.2593 Rana, 1994, Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes, Mol Cell Biol, 14, 5858, 10.1128/MCB.14.9.5858 Flodby, 1996, Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein α, J Biol Chem, 271, 24753, 10.1074/jbc.271.40.24753 Weber, 1991, Key enzymes of gluconeogenesis are dose-dependently reduced in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats, Arch Toxicol, 65, 119, 10.1007/BF02034937 Trautwein, 1994, Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding activity to DNA recognition elements, J Clin Invest, 93, 2554, 10.1172/JCI117266 Trautwein, 1993, Transactivation by NF-IL6/LAP is enhanced by its phosphorylation of its activation domain, Nature, 364, 544, 10.1038/364544a0 Greenbaum, 1995, Coexistence of C/EBPα, β, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth, J Clin Invest, 96, 1351, 10.1172/JCI118170 Alam, 1993, trans-Activation of the α1 acid glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor, J Biol Chem, 268, 15681, 10.1016/S0021-9258(18)82310-9 Umek, 1991, CCAAT-enhancer binding protein, Science, 251, 288, 10.1126/science.1987644 Ron, 1992, Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP), J Clin Invest, 89, 223, 10.1172/JCI115566 Clark, 1991, Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus, Toxicol Appl Pharmacol, 111, 422, 10.1016/0041-008X(91)90247-C Moos, 1994, Acute inflammatory response to sheep red blood cells in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicol Appl Pharmacol, 127, 331, 10.1006/taap.1994.1169 Taylor, 1992, Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone, Toxicol Appl Pharmacol, 117, 126, 10.1016/0041-008X(92)90227-J Yeh, 1995, Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins, Genes Dev, 9, 168, 10.1101/gad.9.2.168 Enan, 1993, 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced alterations in protein phosphorylation in guinea pig adipose tissue, J Biochem Toxicol, 8, 88, 10.1002/jbt.2570080206 Pope, 1994, C/EBPβ regulation of the tumor necrosis factor α gene, J Clin Invest, 94, 1449, 10.1172/JCI117482 Godambe, 1994, Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1β gene, J Immunol, 153, 143, 10.4049/jimmunol.153.1.143