Supplementing preservation solution with mitochondria-targeted H2S donor AP39 protects cardiac grafts from prolonged cold ischemia–reperfusion injury in heart transplantation

American Journal of Transplantation - Tập 19 - Trang 3139-3148 - 2019
Cuilin Zhu1,2,3, Yale Su1,2,3, Smriti Juriasingani3, Hao Zheng2,3, Vitali Veramkovich2,3, Jifu Jiang3, Alp Sener3,4,5,6, Matthew Whiteman7, James Lacefield8,9,10, Dave Nagpal4, Faizah Alotaibi11, Kexiang Liu1, Xiufen Zheng2,3,4,5,6
1Department of Cardiovascular Surgery, The Second Hospital of Jilin University, Changchun, China
2Department of Pathology, Western University, Ontario, Canada
3Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Center, Ontario, Canada
4Department of Surgery, Western University, Ontario, Canada
5Lawson Health Research Institute, Ontario, Canada
6Department of Oncology, Western University, Ontario, Canada
7University of Exeter Medical School, St Luke's Campus, Exeter, UK
8Department of Medical Biophysics, Western University, Ontario, Canada
9Department of Electrical & Computer Engineering, Western University, Ontario, Canada
10Robarts Research Institute, Western University, Ontario, Canada
11Department of Microbiology and Immunology, Western University, Ontario, Canada

Tài liệu tham khảo

Khush, 2018, The international thoracic organ transplant registry of the International Society for Heart and Lung Transplantation: thirty-fifth adult heart transplantation report-2018; focus theme: multiorgan transplantation, J Heart Lung Transplant., 37, 1155, 10.1016/j.healun.2018.07.022 Lund, 2017, The registry of the International Society for Heart and Lung Transplantation: thirty-fourth adult heart transplantation report-2017; focus theme: allograft ischemic time, J Heart Lung Transplant., 36, 1037, 10.1016/j.healun.2017.07.019 Li, 2016, Three preservation solutions for cold storage of heart allografts: a systematic review and meta-analysis, Artif Organs., 40, 489, 10.1111/aor.12585 Andreadou, 2015, The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning, Br J Pharmacol., 172, 1587, 10.1111/bph.12811 Wu, 2018, An update on hydrogen sulfide and nitric oxide interactions in the cardiovascular system, Oxid Med Cell Longev., 2018, 4579140, 10.1155/2018/4579140 Whiteman, 2015, Phosphinodithioate and phosphoramidodithioate hydrogen sulfide donors, Handb Exp Pharmacol., 230, 337, 10.1007/978-3-319-18144-8_17 Szczesny, 2014, AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro, Nitric Oxide., 41, 120, 10.1016/j.niox.2014.04.008 Juriasingani, 2018, H2S supplementation: a novel method for successful organ preservation at subnormothermic temperatures, Nitric Oxide: Biol Chem., 81, 57, 10.1016/j.niox.2018.10.004 Lobb, 2017, Hydrogen sulfide protects renal grafts against prolonged cold ischemia-reperfusion injury via specific mitochondrial actions, Am J Transpl., 17, 341, 10.1111/ajt.14080 Ikeda, 2015, Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice, Nitric Oxide., 49, 90, 10.1016/j.niox.2015.05.001 Latorre, 2018, Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2, Aging., 10, 1666, 10.18632/aging.101500 Karwi, 2017, AP39, a mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling, Br J Pharmacol., 174, 287, 10.1111/bph.13688 Wepler, 2019, The mitochondria-targeted H2S-donor AP39 in a Murine model of combined hemorrhagic shock and blunt chest trauma, Shock (Augusta, GA)., 52, 230, 10.1097/SHK.0000000000001210 Drucker, 2018, Hydrogen sulfide provides intestinal protection during a murine model of experimental necrotizing enterocolitis, J Pediatr Surg., 53, 1692, 10.1016/j.jpedsurg.2017.12.003 Zhang, 2017, Over-expression of growth differentiation factor 15 (GDF15) preventing cold ischemia reperfusion (I/R) injury in heart transplantation through Foxo3a signaling, Oncotarget., 8, 36531, 10.18632/oncotarget.16607 Kannan, 2004, Effect of vitamin B 6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytes, Free Radic Biol Med., 36, 423, 10.1016/j.freeradbiomed.2003.09.012 Zheng, 2009, Novel small interfering RNA-containing solution protecting donor organs in heart transplantation, Circulation., 120, 1099, 10.1161/CIRCULATIONAHA.108.787390 Zhou, 2007, Morphological and functional evaluation of murine heterotopic cardiac grafts using ultrasound biomicroscopy, Ultrasound Med Biol., 33, 870, 10.1016/j.ultrasmedbio.2006.10.016 Szabo, 2014, Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms, Br J Pharmacol., 171, 2099, 10.1111/bph.12369 Covarrubias, 2019, AP39, a Modulator of mitochondrial bioenergetics, reduces antiangiogenic response and oxidative stress in hypoxia-exposed trophoblasts: relevance for preeclampsia pathogenesis, Am J Pathol., 189, 104, 10.1016/j.ajpath.2018.09.007 Sun, 2018, Donor heart preservation with a novel long-term and slow-releasing hydrogen sulfide system, Nitric Oxide., 81, 1, 10.1016/j.niox.2018.09.001 Zhu C, Su Y, Juriasingani S, et al. Supplementing preservation solution with mitochondria-targeted H2S donor AP39 protects cardiac grafts from prolonged cold ischemia–reperfusion injury in heart transplantation [published online ahead of print 2019]. Am J Transplant. https://doi.org/10.1111/ajt.15539