Supplementation with selenium and human immune cell functions

Biological Trace Element Research - Tập 41 - Trang 103-114 - 1994
Martin Roy1, Lidia Kiremidjian-Schumacher2, Harvey I. Wishe1, Martin W. Cohen2, Günther Stotzky3
1Department of Histology and Cell Biology, New York University Dental Center, New York
2Department of Oral Medicine and Pathology, New York University, Dental Center, New York
3Biology Department, New York University, New York

Tóm tắt

Selenium (Se) is an essential nutritional factor that was shown by us to alter the expression of the high affinity interleukin 2 receptor (Il 2-R) and its subunits, cell proliferation, and clonal expansion of cytotoxic T-lymphocytes in mice. This study shows that dietary supplementation of Se-replete humans with 200 μg/d of sodium selenite for 8 wk, or in vitro supplementation with 1×10−7 M Se (as sodium selenite), result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 μg/mL of phytohemagglutinin or alloantigen (mixed lymphocyte reaction) and to express high affinity Il 2-R on their surface. There was a clear correlation between supplementation with Se and enhanced3H-thymidine incorporation into nuclear DNA, preceded by enhanced expression of high affinity Il 2-R. Supplementation with Se can apparently modulate T-lymphocyte mediated immune responses in humans that depend on signals generated by the interaction of interleukin 2 with Il 2-R.

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Biological Trace Element Research

Tập 41

103-114

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