Supplementation of DHA but not DHA with arachidonic acid during pregnancy and lactation influences general movement quality in 12-week-old term infants

British Journal of Nutrition - Tập 103 Số 2 - Trang 235-242 - 2010
Saskia A. van Goor1, D.A. Janneke Dijck‐Brouwer1, Bennard Doornbos2, Jan Jaap Erwich3, Anne Schaafsma4, Frits A.J. Muskiet1, Mijna Hadders‐Algra5
1Laboratory Medicine, University Medical Center Groningen, Internal postal code EA22, PO Box 30.001, 9700 RB Groningen, The Netherlands.
2Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
3Reproductive Origins of Adult Health and Disease (ROAHD)
4FrieslandCampina
5Extremities Pain and Disability (EXPAND)

Tóm tắt

DHA and arachidonic acid (AA) are important for neurodevelopment. A traditional neonatal neurological examination and the evaluation of general movement quality are sensitive techniques for assessing neurodevelopment in young infants. Mildly abnormal general movements at 3 months have been associated with a non-optimal current brain condition. We investigated whether supplementation of DHA during pregnancy and lactation influences the infant's brain development and whether additional AA modulates this effect. Healthy women were randomly assigned to DHA (220 mg/d, n 42), DHA+AA (220 mg each/d, n 41) or control (n 36), from about week 17 (range 14–20 weeks) of pregnancy until 12 weeks postpartum. The control and the DHA+AA groups had approximately comparable dietary DHA/AA ratios. The standardised neonatal neurological examination was carried out at 2 weeks. General movement quality was assessed at 2 and 12 weeks. Neither DHA alone nor DHA+AA influenced outcomes in the traditional examination. General movement quality of infants in the DHA group was lower than that of infants in the other two groups, especially at 12 weeks: 61 % of the infants in the DHA group showed mildly abnormal general movements compared with 31 % in the control group (P = 0·008) and 34 % in the DHA+AA group (P = 0·015). We conclude that general movement quality at 12 weeks is sensitive to the maternal dietary DHA/AA balance.

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Thông tin
Thông tin xuất bản

British Journal of Nutrition

Tập 103 Số 2

235-242

Thông tin tác giả