Supercritical antisolvent precipitation of micro- and nano-particles

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E. Reverchon, G. Della Porta, A. Di Trolio, Morphological analysis of nanoparticles generated by SAS, in: E. Reverchon (Ed.), Proceedings of 4th Italian Conference on Supercritical Fluids and their Applications, CVES, Salerno(I), 1997, p.335.

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P.M. Gallagher, M.P. Coffey, V.J. Krukonis, N. Klasutis, Gas anti-solvent recrystallization: new process to recrystallize compounds insoluble in supercritical fluids, in: Supercritical fluids Science and Technology, ACS Symp. Series 406, 1989, p. 334.

J.C. de la Fuente Badilla, C.J. Peters, J. de Swaan Arons, Selection of the appropriate combination solvent, antisolvent and process conditions for the gas-antisolvent process, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol. 1, 1998, p. 237.

A. Kordikowski, C.J. Peters, J. de Swaan Arons, Thermodynamic analysis of the gas-antisolvent crystallization process, in: M. Perrut, G. Brunner (Eds.), Proceedings of the 3rd International Symposium On Supercritical Fluids, INPL, Vandeuvre (Fr), 1994, p. 217.

P.M. Gallagher, V.J. Krukonis, L.J. VandeKieft, Gas anti-solvent recrystallization: application to the separation and subsequent processing of RDX and HMX, in: M.A. McHugh (Ed.), Proceedings 2nd International Symposium on Supercritical Fluids, 1991, p. 45.

J.-G. Cai, X.-C. Liao, Z.-Y. Zhou, Microparticle formation and crystallization rate of HMX using supercritical carbon dioxide antisolvent recrystallization, in: K. Arai (Ed.), Proceedings of 4th International Symposium On Supercritical Fluids, Tohoku Univ. Press, Sendai (Jap), 1997, p. 23.

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U. Teipel, H. Foerter-Barth, H. Krober, H. Krause, Formation of particles with compressed gases as anti-solvent, in: Proceedings of 3rd World Congress on Particle Technology, 1998, paper 189.

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Yeo, 1993, Supercritical antisolvent process for substituted para-linked aromatic polyamides: phase equilibrium and morphology study, Macromolecules, 26, 6207, 10.1021/ma00075a012

Yeo, 1995, Supercritical antisolvent process for a series of substituted para-linked aromatic polyamides, Macromolecules, 28, 1316, 10.1021/ma00108a073

Dixon, 1994, Microcellular microspheres and microballoons by precipitation with a vapour–liquid compressed fluid antisolvent, Polymer, 35, 3998, 10.1016/0032-3861(94)90286-0

K.P. Johnston, G. Luna-Barcenas, D. Dixon, S. Mawson, Polymeric materials by precipitation with a compressed fluid antisolvent, in: M. Perrut, G. Brunner (Eds.), Proceedings of the 3rd International Symposium On Supercritical Fluids, INPL, Vandeuvre (Fr), 1994, p. 359.

Luna-Barcenas, 1995, Semicrystalline microfibrils and hollow fibres by precipitation with a compressed fluid antisolvent, Polymer, 36, 3173, 10.1016/0032-3861(95)97881-F

L. Benedetti, A. Bertucco, M. Lora, P. Pallado, Formation of biocompatible polymer microspheres using a supercritical fluid, in: I. Kikic, P. Alessi (Eds.), Proceedings of the 3rd Congresso sui Fluidi Supercritici e le Loro Applicazioni, CSUT, Trieste (I), 1995, p. 221.

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Bleich, 1994, Influence of gas density and pressure on micropaticles produced with the ASES process, Int. J. Pharm., 106, 77, 10.1016/0378-5173(94)90278-X

Thies, 1996, Production of large sized microparticles with supercritical gases, J. Pharm. Res., 13, S161

M. Rantakyla, M. Jantti, S. Jaarmo, O. Aaltonen, Modeling droplet–gas interaction and particle formation in gas–anti-solvent system, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol. 1, 1998, p. 333.

I. De Rosa, Micronization of biopolymers using supercritical antisolvent precipitation, MSc Thesis, University of Salerno, Italy, 1998.

Ruchatz, 1996, Thymopentin loaded PLGA microparticles produced by the ASES process, J. Pharm. Res., 13, S161

S. Saim, B. Subramaniam, R.A. Rajewski, V.J. Stella, Particle micronization with compressed gas antisolvents, J. Pharm. Res. 13 (1996) S273.

A. Bertucco, P. Pallado, L. Benedetti, Formation of biocompatible polymer microspheres for controlled drug delivery by a supercritical antisolvent technique, in: R. von Rohr, Ch. Trepp (Eds.), Proceedings of High Pressure Chemical Engineering, Elsevier, 1996, p. 217.

A. Bertucco, F. Vaccaro, P. Pallado, Drugs encapsulation using a compressed gas antisolvent precipitation, in: Ed. E. Reverchon, Proceedings 4th Italian Conference on Supercritical Fluids and Their Applications, CVES, Salerno (I), 1997, p. 327.

R. Falk, J.D. Meyer, T.W. Randolph, W.S. Dernell, M.C. Manning, Preparation of a biodegradable implant for the treatment of osteomyelitis using precipitation with supercritical carbon dioxide, presented at AIChE Annual meeting, 1997, paper 109e.

Winters, 1996, Precipitation of proteins in supercritical carbon dioxide, J. Pharm. Sci., 85, 586, 10.1021/js950482q

M.H. Hanna, P. York, B.Yu. Shekunov, Control of the polymorphic forms of a drug substance by solution enhanced dispersion by supercritical fluids, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol 1, 1998, p. 325.

E. Reverchon, G. Della Porta, Production of antibiotic micro- and nano-particles by supercritical antisolvent precipitation, Powder Technol. (in press).

E. Reverchon, G. Della Porta, P. Pallado, Supercritical antisolvent precipitation of drug microparticles targeted for aerosol delivey, Pharm. Res. (in press).

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Gallagher-Wetmore, 1994, Application of supercritical fluids in recrystallization: nucleation and gas antisolvent techniques, Respiratory Drug Deliv., 4, 287

P.G. Debenedetti, Supercriticl Fluids as Particle Formation Media: from Fundamentals to Applications, in:, M. Perrut, G. Brunner, Proceedings of the 3rd International Symposium on Supercritical Fluids, INPL, Vandeuvre (Fr), 1994, p. 213.

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S. Palakodaty, P. York, M. Hanna, J. Pritchard, Crystallization of lactose using solution enhanced dispersion by supercritical fluids technique, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol. 1, 1998, p. 275.

R. Sloan, M.E. Hollowood, G.O. Humprey, W. Ashraf, P. York, Supercritical fluid processing: preparation of stable protein particles, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol. 1, 1998, p. 301.

J. Robertson, M.B. King, J.P.K. Seville, Particle production using near-critical solvents, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol. 1, 1998, p. 339.

Y.-H. Chou, D.L. Tomasko, GAS crystallization of polymer-pharmaceutical composite particles, in: K. Arai (Eds.), Proceedings of the 4th International Symposium on Supercritical Fluids, Tohoku Univ. Press, Sendai (Jap), 1997, p. 55.

A. Weber, M. Beutin, J. Tschenjaew, R. Kummel, Compressed fluid antisolvent crystallization for controlled particle design, in: Proceedings 4th International Workshop on crystal growth of organic materials, 1997, p. 214.

A. Weber, J. Tschernjaew, R. Kummel, Coprecipitation with compressed antisolvents for the manufacture of microcomposites, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol. 1, 1998, p. 243.

R. Thiering, M. Charoenchaitrakool, L. Sze Tu, F. Dehghani, A.K. Dillow, N.L. Foster, in: M. Perrut, P. Subra (Eds.), Proceedings of the 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol. 1, 1998, p. 291.

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Gao, 1998, Fine particles preparation of Red Lake C pigment by supercritical fluid, J. Supercrit. Fluids, 13, 369, 10.1016/S0896-8446(98)00074-6

E. Reverchon, G. Della Porta, C. Celano, A. Di Trolio, S. Pace, Processo di formazione di microparticelle di composti precursori di superconduttori per precipitazione indotta da fluidi supercritici, Italian Patent SA97A/10, 1997.

E. Reverchon, A. A. Barba, G. Della Porta, D. Sannino, P. Ciambelli, Production of catalyst precursors by supercritical antisolvent precipitation, in: E. Reverchon (Ed.), Proceedings of the 4th Italian Conference on Supercritical Fluids and Their Applications, CVES, Salerno (I), 1997, p. 385.

E. Reverchon, G. Della Porta, D. Sannino, L. Lisi, P. Ciambelli, Supercritical antisolvent precipitation: a novel technique to produce catalyst precursors. Preparation and characterization of samarium oxide nanoparticles, in: B. Delmon, P.A. Jacobs, R. Maggi, J.A. Martens, P. Grange, G. Poncelet (Eds.), Proceedings 7th International Symposium On Scientific Bases for the Preparation of Heterogeneous Catalysts, Elsevier, 1998, p. 349.

E. Reverchon, G. Della Porta, D. Sannino, P. Ciambelli, Supercritical antisolvent precipitation of nanoparticles of a zinc oxide precursor, Powder Technol. (in press).

E. Reverchon, SAS Process: Its application to microparticle production and natural products fractionation, plenary lecture in: M. Perrut, P. Subra (Eds.), Proceedings of 5th Meeting on Supercritical Fluids, INPL, Vandeuvre (Fr), vol 1, 1998, p. 221.

M. G. Falivene, Supercritical antisolvent micronization of pharmaceutical active principles: tetracycline, amoxicillin and salbutamol, MSc thesis, University of Salerno, Italy, 1998.

Dixon, 1991, Molecular thermodynamics of solubilities in gas antisolvent crystallization, AIChE J., 37, 1441, 10.1002/aic.690371002

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I. Kikic, A. Bertucco, M. Lora, Thermodynamic and mass transfer for the simulation of recrystallization processes with a supercritical antisolvent, in: E. Reverchon (Ed.), Proceedings of 4th Italian Conference on Supercritical Fluids and their Applications, CVES, Salerno (I), 1997, p. 299.

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