Sulphasalazine-induced forms of colitis
Tóm tắt
Administration of oral or rectal sulphasalazine may lead to a number of potentially serious and life-threatening adverse reactions, including specific gastrointestinal complications. Mimicry and/or exacerbation of either ulcerative colitis or Crohn’s colitis may occur and has been described in several previous case reports. In addition, challenge studies after oral and rectal sulphasalazine have demonstrated unequivocal worsening of rectal biopsies. More recently, sulphasalazine treatment resulted in the development of pseudomembranous colitis associated with detection ofClostridium difficile toxin in a patient with ankylosing spondylitis and no evident pre-existing intestinal disease. This observation is particularly interesting because of the potential effects of the medication in altering the enteric microflora.
Tài liệu tham khảo
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