Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner
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Herr, 2010, Dietary constituents of broccoli and other cruciferous vegetables: implications for prevention and therapy of cancer, Cancer Treat Rev, 36, 377, 10.1016/j.ctrv.2010.01.002
Higdon, 2007, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Pharmacol Res, 55, 224, 10.1016/j.phrs.2007.01.009
Kim, 2009, Conference on “Multidisciplinary approaches to nutritional problems”. Symposium on “Nutrition and health”. Cruciferous vegetable intake and the risk of human cancer: epidemiological evidence, Proc Nutr Soc, 68, 103, 10.1017/S0029665108008884
Aggarwal, 2006, Molecular targets of dietary agents for prevention and therapy of cancer, Biochem Pharmacol, 71, 1397, 10.1016/j.bcp.2006.02.009
Navarro, 2011, Mechanisms of action of isothiocyanates in cancer chemoprevention: an update, Food Funct, 2, 579, 10.1039/c1fo10114e
Brown, 1810, Biological targets of isothiocyanates, Biochim Biophys Acta, 2011, 888
Farkouh, 2007, Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib, Ann Rheum Dis, 66, 764, 10.1136/ard.2006.066001
Layton, 2008, Evaluation of risk profiles for gastrointestinal and cardiovascular adverse effects in nonselective NSAID and COX-2 inhibitor users: a cohort study using pharmacy dispensing data in The Netherlands, Drug Saf, 31, 143, 10.2165/00002018-200831020-00004
Singh, 2007, Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma, Am J Respir Crit Care Med, 176, 988, 10.1164/rccm.200704-588OC
Singh, 2006, Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis, Arthritis Res Ther, 8, R153, 10.1186/ar2047
Maxwell, 2005, COX-2 selective inhibitors—important lessons learned, Lancet, 365, 449, 10.1016/S0140-6736(05)70247-6
Hippisley-Cox, 2005, Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis, BMJ, 330, 1366, 10.1136/bmj.330.7504.1366
Heiss, 2001, Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms, J Biol Chem, 276, 32008, 10.1074/jbc.M104794200
Shibata, 2010, Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice, J Nutr Biochem, 21, 702, 10.1016/j.jnutbio.2009.04.007
Wu, 2004, Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system, Proc Natl Acad Sci U S A, 101, 7094, 10.1073/pnas.0402004101
Talalay, 2007, Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation, Proc Natl Acad Sci U S A, 104, 17500, 10.1073/pnas.0708710104
Lee, 2009, Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin, J Mol Med (Berlin), 87, 1251, 10.1007/s00109-009-0532-6
Lee, 2011, Phenethyl isothiocyanate inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory responses in mouse skin, J Med Food, 14, 377, 10.1089/jmf.2010.1296
Yehuda, 2012, Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin, Inflamm Res, 61, 735, 10.1007/s00011-012-0465-3
Nims, 1996, Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds, Methods Enzymol, 268, 93, 10.1016/S0076-6879(96)68012-4
Steinmetz, 1996, Vegetables, fruit, and cancer prevention: a review, J Am Diet Assoc, 96, 1027, 10.1016/S0002-8223(96)00273-8
Morse, 1989, Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates, Carcinogenesis, 10, 1757, 10.1093/carcin/10.9.1757
Morse, 1989, Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung, Cancer Res, 49, 2894
Guo, 1993, Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice, Carcinogenesis, 14, 1167, 10.1093/carcin/14.6.1167
Jiao, 1994, Structure–activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice, Cancer Res, 54, 4327
Lui, 2003, Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma, Carcinogenesis, 24, 1705, 10.1093/carcin/bgg127
Zhang, 1992, A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure, Proc Natl Acad Sci U S A, 89, 2399, 10.1073/pnas.89.6.2399
Posner, 1994, Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes, J Med Chem, 37, 170, 10.1021/jm00027a021
Lu, 2006, Inflammation, a key event in cancer development, Mol Cancer Res, 4, 221, 10.1158/1541-7786.MCR-05-0261
Hussain, 2007, Inflammation and cancer: an ancient link with novel potentials, Int J Cancer, 121, 2373, 10.1002/ijc.23173
Raman, 2007, Role of chemokines in tumor growth, Cancer Lett, 256, 137, 10.1016/j.canlet.2007.05.013
Suganuma, 2011, Stimulation of phagocytosis by sulforaphane, Biochem Biophys Res Commun, 405, 146, 10.1016/j.bbrc.2011.01.025
Harvey, 2011, Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model, Sci Transl Med, 3, 10.1126/scitranslmed.3002042
Poltorak, 1998, Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene, Science, 282, 2085, 10.1126/science.282.5396.2085
Arthur, 2013, Mitogen-activated protein kinases in innate immunity, Nat Rev Immunol, 13, 679, 10.1038/nri3495
Suzuki, 2006, Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, Biomed Pharmacother, 60, 578, 10.1016/j.biopha.2006.07.089
Ren, 2013, NF-κB p65 and c-Rel subunits promote phagocytosis and cytokine secretion by splenic macrophages in cirrhotic patients with hypersplenism, Int J Biochem Cell Biol, 45, 335, 10.1016/j.biocel.2012.11.012
Guha, 2001, Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression, Blood, 98, 1429, 10.1182/blood.V98.5.1429
Guha, 2001, LPS induction of gene expression in human monocytes, Cell Signal, 13, 85, 10.1016/S0898-6568(00)00149-2
Ganju, 1998, The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways, J Biol Chem, 273, 23169, 10.1074/jbc.273.36.23169
Hong, 2005, Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane, Chem Res Toxicol, 18, 1917, 10.1021/tx0502138
Rachakonda, 2008, Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3, Chem Res Toxicol, 21, 705, 10.1021/tx700302s
Hu, 2011, Modification of keap1 cysteine residues by sulforaphane, Chem Res Toxicol, 24, 515, 10.1021/tx100389r
Hu, 2007, Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents, Biol Chem, 388, 1069, 10.1515/BC.2007.135
Byun, 2006, Cysteine-179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines, Exp Mol Med, 38, 546, 10.1038/emm.2006.64
Ahmad, 2006, Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179, J Biol Chem, 281, 35764, 10.1074/jbc.M607160200
Kim, 2012, Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-κB and AP-1 signaling pathways, Vascul Pharmacol, 56, 131, 10.1016/j.vph.2011.11.007