Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase

TA Shapiro, 2001, Disposition of chemoprotective glucosinolates and isothiocyanates of broccoli sprouts, Cancer Epidemiol Biomark Prev, 10, 501

AT Dinkova-Kostova, 2010, The effectiveness of the isothiocyanate sulforaphane in chemoprotection, Acta Hortic, 867, 27, 10.17660/ActaHortic.2010.867.2

N Juge, 2007, Molecular basis for chemoprevention by sulforaphane: A comprehensive review, Cell Mol Life Sci, 64, 1105, 10.1007/s00018-007-6484-5

P Talalay, 2001, Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism, J Nutr, 131, 3027S, 10.1093/jn/131.11.3027S

JW Fahey, 1997, Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens, Proc Natl Acad Sci USA, 94, 10367, 10.1073/pnas.94.19.10367

JW Fahey, 2012, Notes from the field: “Green” chemoprevention as frugal medicine, Cancer Prev Res, 5, 179, 10.1158/1940-6207.CAPR-11-0572

JW Fahey, 2012, Protection of humans by plant glucosinolates: Efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora, Cancer Prev Res, 5, 603, 10.1158/1940-6207.CAPR-11-0538

JW Fahey, 2013, Frugal medicine: Health-span extension through green chemoprevention, Amer Med Assoc Virtual Mentor, 15, 311, 10.1001/virtualmentor.2013.15.4.stas1-1304

Y Zhang, 1992, A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure, Proc Natl Acad Sci USA, 89, 2399, 10.1073/pnas.89.6.2399

M Shikita, 1999, An unusual case of ‘uncompetitive activation&apos; by ascorbic acid: Purification and kinetic properties of a myrosinase from <italic>Raphanus sativus</italic> seedlings, Biochem J, 341, 725, 10.1042/bj3410725

KL Wade, 2015, Novel purification of active myrosinase from plants by aqueous two-phase counter-current chromatography, Phytochem Anal, 26, 47, 10.1002/pca.2535

JW Fahey, 2001, The chemical diversity and distribution of glucosinolates and isothiocyanates among plants, Phytochemistry, 56, 5, 10.1016/S0031-9422(00)00316-2

L Ye, 2002, Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans, Clin Chim Acta, 316, 43, 10.1016/S0009-8981(01)00727-6

PA Egner, 2011, Bioavailability of sulforaphane from two forms of broccoli sprout beverage: Results of a short term, cross-over clinical trial in Qidong, People’s Republic of China, Cancer Prev. Res., 4, 384, 10.1158/1940-6207.CAPR-10-0296

PA Egner, 2014, Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: Results of a randomized clinical trial in China, Cancer Prev Res, 7, 813, 10.1158/1940-6207.CAPR-14-0103

TW Kensler, 2005, Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People&apos;s Republic of China, Cancer Epidemiol Biomark Prev, 14, 2605, 10.1158/1055-9965.EPI-05-0368

EV Knatko, 2015, Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans, Cancer Prev Res, 8, 475, 10.1158/1940-6207.CAPR-14-0362

JW Fahey, 2007, Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymes, Chem Res Toxicol, 20, 572, 10.1021/tx7000459

TA Shapiro, 2006, Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: A clinical Phase I study, Nutr Cancer, 55, 53, 10.1207/s15327914nc5501_7

K Singh, 2014, Sulforaphane treatment of autism spectrum disorder (ASD), Proc Natl Acad Sci USA, 111, 15550, 10.1073/pnas.1416940111

T Prestera, 1996, Comprehensive, chromatographic and spectroscopic methods for the separation and identification of intact glucosinolates, Anal Biochem, 239, 168, 10.1006/abio.1996.0312

KL Wade, 2007, Improved hydrophilic interaction chromatography method for the identification and quantification of glucosinolates, J Chrom A, 1154, 469, 10.1016/j.chroma.2007.04.034

D Fisher, 2005, Technology transfer and scale-up of a potential cancer-preventive plant [secondary product]: Dynamic extraction of glucoraphanin, J Liq Chromatog Rel Technol, 28, 1913, 10.1081/JLC-200063563

L Tang, 2006, Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract, Molec Cancer Therapeut, 5, 935, 10.1158/1535-7163.MCT-05-0476

Y Zhang, 1996, Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol, Anal Biochem, 239, 160, 10.1006/abio.1996.0311

JE Bierwirth, 2015, Flavor misattribution: A novel approach to improving compliance and blinding in food-based clinical interventions, NFS J

D Heber, 2014, Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles, Food Function, 5, 35, 10.1039/C3FO60277J

R Brown, 2015, Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways, Respir Res

JJ Alumkal, 2015, A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer, Investigational New Drugs, 33, 480, 10.1007/s10637-014-0189-z

EJ Poulton, 2013, Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo, Toxicol Appl Pharmacol, 266, 122, 10.1016/j.taap.2012.10.029

BG Cipolla, 2015, Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy, Cancer Prev Res, 8, 712, 10.1158/1940-6207.CAPR-14-0459