Sudden death in racehorses: postmortem examination protocol

Journal of Veterinary Diagnostic Investigation - Tập 29 Số 4 - Trang 442-449 - 2017
Santiago S. Diab1, Robert H. Poppenga1, Francisco A. Uzal1
1California Animal Health and Food Safety Laboratory System, University of California, Davis, CA (Diab, Poppenga) and San Bernardino, CA (Uzal)

Tóm tắt

In racehorses, sudden death (SD) associated with exercise poses a serious risk to jockeys and adversely affects racehorse welfare and the public perception of horse racing. In a majority of cases of exercise-associated sudden death (EASD), there are no gross lesions to explain the cause of death, and an examination of the cardiovascular system and a toxicologic screen are warranted. Cases of EASD without gross lesions are often presumed to be sudden cardiac deaths (SCD). We describe an equine SD autopsy protocol, with emphasis on histologic examination of the heart (“cardiac histology protocol”) and a description of the toxicologic screen performed in racehorses in California. By consistently utilizing this standardized autopsy and cardiac histology protocol, the results and conclusions from postmortem examinations will be easier to compare within and across institutions over time. The generation of consistent, reliable, and comparable multi-institutional data is essential to improving the understanding of the cause(s) and pathogenesis of equine SD, including EASD and SCD.

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Tài liệu tham khảo

10.1007/s12265-012-9433-0

10.1016/j.carpath.2010.02.003

10.1002/ar.1091580405

10.2746/042516406777749182

10.2746/0425164054530597

10.1111/j.2042-3306.1988.tb01468.x

10.1079/AHR200353

10.2460/javma.2005.226.1881

10.1177/1040638714559970

10.1016/j.pharmthera.2013.04.010

Gelberg HB, 1985, J Am Vet Med Assoc, 187, 1354

10.1111/j.1439-0264.1996.tb00057.x

Gunson DE, 1988, J Am Vet Med Assoc, 193, 102

10.1016/0300-9629(94)90083-3

10.1007/BF01623885

10.1016/S0008-6363(02)00226-2

10.1161/01.RES.20.6.638

10.1002/ar.1091530405

10.1053/pcad.2002.130388

10.1111/j.2042-3306.1994.tb04395.x

10.1111/j.1439-0264.1979.tb00686.x

King JM, et al. The Necropsy Book: A Guide for Veterinary Students, Residents, Clinicians, Pathologists, and Biological Researchers. 4th ed. Gurnee, IL: Charles Louis Davis DVM Foundation, 2005.

10.1292/jvms.61.921

Kiryu K, 1987, Heart Vessels Suppl, 2, 40

10.1002/ar.1092360310

10.1111/j.2042-3306.1987.tb02591.x

10.1111/j.2042-3306.2010.00164.x

Miller LM, 2012, Pathologic Basis of Veterinary Disease, 5, 539

10.1111/j.1540-8159.2010.02838.x

Nabipour A., 2012, Turk J Vet Anim Sci, 36, 463

10.1080/09712119.2000.9706337

10.1016/S0022-2828(87)80532-1

10.1016/S0022-2828(85)80024-9

10.1016/S0022-2828(86)80290-5

10.1016/S0007-1935(17)30987-9

10.1002/ar.1092240303

10.1016/B978-0-7020-5319-1.00012-8

10.1679/aohc.49.283

10.1002/clc.4960160316

10.1002/clc.4960160410

10.1016/j.hrthm.2009.01.021

10.1152/japplphysiol.01319.2004