Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Nature - Tập 496 Số 7444 - Trang 238-242 - 2013
Gillian M. Tannahill1, Annie M. Curtis1, Juraj Adamik2, Eva M. Pålsson‐McDermott1, Anne F. McGettrick1, Gautam Goel3, Christian Frezza4, Nicholas J. Bernard1, Beth Kelly1, Niamh H. Foley1, Liang Zheng4, Agnès Gardet5, Zhen Tong6, S. S. Jany1, Sinéad C. Corr1, Moritz Haneklaus1, Brian E. Caffrey7, Kerry A. Pierce5, Sarah R. Walmsley8, Federico C. Beasley9, Eoin P. Cummins10, Victor Nizet9, Moira K. B. Whyte8, Cormac T. Taylor10, Hening Lin6, Seth L. Masters11, Eyal Gottlieb4, Vincent P. Kelly1, Clary B. Clish5, Philip E. Auron2, Ramnik J. Xavier12, Luke O'neill1
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
2Department of Biological Sciences, Duquesne University, Pittsburgh, 15282, Pennsylvania, USA
3Centre for Computational and Integrative Biology, Massachusetts General Hospital, Richard B. Simches Research Center, Boston, 02114, Massachusetts, USA
4Apoptosis and Tumour Physiology Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK,
5The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, 02142, Massachusetts, USA
6Department of Chemistry and Chemical Biology, Cornell University, Ithaca, 14853, New York, USA
7Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
8Department of Infection and Immunity, Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield S10 2RX, UK,
9Division of Pediatrics, V. Nizet Laboratory, Centre for Neural Circuits and Behaviour, University of California, La Jolla, 92093-0687, California, USA
10Conway Institute, University College Dublin, Dublin 4, Ireland
11Inflammation Division, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia,
12Medical Research Council Cancer Cell Unit Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0X2, UK,

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