Successive bilateral frontal controlled cortical impact injuries show behavioral savings

Center for Disease Control, 2010 Bazarian, 2005, Mild traumatic brain injury in the United States, 1998–2000, Brain Injury, 19, 85, 10.1080/02699050410001720158 Ashman, 2006, Neurobehavioral consequences of traumatic brain injury, The Mount Sinai Journal of Medicine, 73, 999 N.I.H. Consensus Development Panel on Rehabilitation of Persons With Traumatic Brain Injury, 1999, Rehabilitation of Persons With Traumatic Brain Injury, The Journal of the American Medical Association, 282, 974, 10.1001/jama.282.10.974 Brody, 2006, Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury, Experimental Neurology, 197, 330, 10.1016/j.expneurol.2005.10.020 Bury, 2002, Unilateral sensorimotor cortex lesions in adult rats facilitate motor skill learning with the unaffected forelimb and training-induced dendritic structural plasticity in the motor cortex, The Journal of Neuroscience, 22, 8597, 10.1523/JNEUROSCI.22-19-08597.2002 Kleim, 2008, Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage, Journal of Speech, Language, and Hearing Research, 51, S225, 10.1044/1092-4388(2008/018) Kolb, 1991, Sparing of function after neonatal frontal lesions correlates with increased cortical dendritic branching: a possible mechanism for the Kennard effect, Behavioural Brain Research, 43, 51, 10.1016/S0166-4328(05)80051-8 Sabel, 1984, Gangliosides minimize behavioral deficits and enhance structural repair after brain injury, Journal of Neuroscience Research, 12, 429, 10.1002/jnr.490120227 Schallert, 2000, Experience-associated structural events, subependymal cellular proliferative activity, and functional recovery after injury to the central nervous system, Journal of Cerebral Blood Flow and Metabolism, 20, 1513, 10.1097/00004647-200011000-00001 Scheff, 2005, Synaptogenesis in the hippocampal CA1 field following traumatic brain injury, Journal of Neurotrauma, 22, 719, 10.1089/neu.2005.22.719 Allen, 2000, Conditioning effects of repetitive mild neurotrauma on motor function in an animal model of focal brain injury, The Journal of Neuroscience, 99, 93, 10.1016/S0306-4522(00)00185-8 Laurer, 2001, Mild head injury increasing the brain's vulnerability to a second concussive impact, Journal of Neurosurgery, 95, 859, 10.3171/jns.2001.95.5.0859 Uryu, 2002, Repetitive mild brain trauma accelerates Aβ deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis, The Journal of Neuroscience, 22, 446, 10.1523/JNEUROSCI.22-02-00446.2002 Adametz, 1959, Rate of recovery of functioning in cats with rostral reticular lesions: an experimental study, Journal of Neurosurgery, 16, 85, 10.3171/jns.1959.16.1.0085 Walbran, 1975, Age and serial ablations of somatosensory cortex in the rat, Physiology & Behavior, 17, 13, 10.1016/0031-9384(76)90261-4 Spear, 1975, Recovery of pattern discrimination ability in rats receiving serial or one-stage visual cortex lesions, Brain Research, 94, 337, 10.1016/0006-8993(75)90066-9 Dru, 1975, Recovery of pattern vision following serial lesions of striate cortex in rats, Brain Research, 88, 353, 10.1016/0006-8993(75)90398-4 Finger, 1971, Effects of successive and simultaneous lesions of somatosensory cortex on tactile discrimination in the rat, Journal of Comparative and Physiological Psychology, 77, 221, 10.1037/h0031648 Fass, 1980, Behavioral symptoms following serial or simultaneous septal-forebrain lesions: similar syndromes, Physiology & Behavior, 25, 683, 10.1016/0031-9384(80)90370-4 Reyes, 1973, Serial thalamic lesions and tactile discrimination in the rat, Behavioral Biology, 8, 807, 10.1016/S0091-6773(73)80123-3 Nonneman, 1979, Functional recovery after serial ablation of prefrontal cortex in the rat, Physiology & Behavior, 22, 895, 10.1016/0031-9384(79)90334-2 De Castro, 1988, Recovery of sensorimotor function after frontal cortex damage in rats: evidence that the serial lesion effect is due to serial recovery, Behavioral Neuroscience, 102, 843, 10.1037/0735-7044.102.6.843 Glendenning, 1972, Effects of training between two unilateral lesions of visual cortex upon ultimate retention of black-white discrimination habits by rats, Journal of Comparative and Physiological Psychology, 80, 216, 10.1037/h0033140 Bell, 1981, Effects of one- and two-stage lesions of the posterior hypothalamus on temperature regulation in the rat, Brain Research, 219, 451, 10.1016/0006-8993(81)90309-7 Lighthall, 1988, Controlled cortical impact: a new experimental brain injury model, Journal of Neurotrauma, 5, 1, 10.1089/neu.1988.5.1 Dixon, 1987, A fluid percussion model of experimental brain injury in the rat, Journal of Neurosurgery, 67, 110, 10.3171/jns.1987.67.1.0110 Myer, 2006, Essential protective roles of reactive astrocytes in traumatic brain injury, Brain, 129, 2761, 10.1093/brain/awl165 Arvin, 1996, The role of inflammation and cytokines in brain injury, Neuroscience and Biobehavioral Reviews, 20, 445, 10.1016/0149-7634(95)00026-7 Oyesiku, 1999, Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain, Brain Research, 833, 161, 10.1016/S0006-8993(99)01501-2 Smith, 2000, Effects of the novel NMDA receptor antagonist gacyclidine on recovery from medial frontal cortex contusion injury in rats, Neural Plasticity, 7, 73, 10.1155/NP.2000.73 Hamm, 1994, The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury, Journal of Neurotrauma, 11, 187, 10.1089/neu.1994.11.187 Vonder Haar, 2011, Continuous nicotinamide administration improves behavioral recovery and reduces lesion size following bilateral frontal controlled cortical impact injury, Behavioural Brain Research, 224, 311, 10.1016/j.bbr.2011.06.009 Barnes, 1979, Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat, Journal of Comparative and Physiological Psychology, 93, 74, 10.1037/h0077579 Dirnagl, 2003, Ischemic tolerance and endogenous neuroprotection, Trends in Neurosciences, 26, 248, 10.1016/S0166-2236(03)00071-7 Hirota, 1996, Its mechanism(s) of action and unusual clinical uses, British Journal of Anaesthesia, 77, 441, 10.1093/bja/77.4.441 Echemendia, 2001, Mild traumatic brain injury in sports: neuropsychology's contribution to a developing field, Neuropsychology Review, 11, 69, 10.1023/A:1016651217141 Guskiewicz, 2003, Cumulative effects associated with recurrent concussion in collegiate football players, The Journal of the American Medical Association, 290, 2549, 10.1001/jama.290.19.2549 Roberts, 1990, The occult aftermath of boxing, Journal of Neurology, Neurosurgery, and Psychiatry, 53, 373, 10.1136/jnnp.53.5.373 Tokuda, 1991, Re-examination of ex-boxers’ brains using immunohistochemistry with antibodies to amyloid β-protein and tau protein, Acta Neuropathologica, 82, 280, 10.1007/BF00308813 Creeley, 2004, Multiple episodes of mild traumatic brain injury result in impaired cognitive performance in mice, Academic Emergency Medicine, 11, 809, 10.1111/j.1553-2712.2004.tb00761.x DeFord, 2004, Repeated mild brain injuries result in cognitive impairment in B6C3F1 mice, Journal of Neurotrauma, 19, 427, 10.1089/08977150252932389