Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

Immunity - Tập 49 Số 6 - Trang 1148-1161.e7 - 2018
Christopher Garris1,2, Sean P. Arlauckas1,3, Rainer H. Köhler1, Marcel P. Trefny4,5, Seth B. Garren1, Cécile Piot1, Camilla Engblom1, Christina Pfirschke1, Marie Siwicki1,2, Jeremy Gungabeesoon1, Gordon J. Freeman6, Sarah Warren7, SuFey Ong7, Erica Browning8, Chris Twitty8, Robert H. Pierce8, Mai H. Le8, Alain P. Algazi9, Adil Daud9, Sara I. Pai10, Alfred Zippelius5, Ralph Weissleder1,3,11, Mikaël J. Pittet1,3
1Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St., CPZN 5206, Boston, MA, 02114 USA
2Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA
3Department of Radiology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA
4Cancer Immunology, Department of Biomedicine and Medical Oncology, University Hospital Basel, Switzerland
5Medical Oncology, Universitätsspital Basel, Basel, Switzerland
6Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
7NanoString Technologies, 500 Fairview Ave N, Seattle, WA, 98109, USA
8Oncosec Inc, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA
9University of California, San Francisco Medical Center-Mt. Zion, 1600 Divisadero St, San Francisco, CA 94115, USA
10Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
11Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, MA, 02115 USA

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