Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
Tóm tắt
Từ khóa
Tài liệu tham khảo
Alloatti, 2017, Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity, J. Exp. Med., 214, 2231, 10.1084/jem.20170229
Arlauckas, 2017, In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy, Sci. Transl. Med., 9, 9, 10.1126/scitranslmed.aal3604
Ayers, 2017, IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade, J. Clin. Invest., 127, 2930, 10.1172/JCI91190
Beatty, 2011, CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans, Science, 331, 1612, 10.1126/science.1198443
Broz, 2014, Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity, Cancer Cell, 26, 638, 10.1016/j.ccell.2014.09.007
Byrne, 2016, CD40 stimulation obviates innate sensors and drives T cell immunity in cancer, Cell Rep., 15, 2719, 10.1016/j.celrep.2016.05.058
Cella, 1996, Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation, J. Exp. Med., 184, 747, 10.1084/jem.184.2.747
Dahan, 2015, FcγRs modulate the anti-tumor activity of antibodies targeting the PD-1/PD-L1 axis, Cancer Cell, 28, 285, 10.1016/j.ccell.2015.08.004
Daud, 2008, Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma, J. Clin. Oncol., 26, 5896, 10.1200/JCO.2007.15.6794
de Mingo Pulido, 2018, TIM-3 regulates CD103+ dendritic cell function and response to chemotherapy in breast cancer, Cancer Cell, 33, 60, 10.1016/j.ccell.2017.11.019
Engblom, 2016, The role of myeloid cells in cancer therapies, Nat. Rev. Cancer, 16, 447, 10.1038/nrc.2016.54
Galon, 2013, The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures, Immunity, 39, 11, 10.1016/j.immuni.2013.07.008
Gordon, 2017, PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity, Nature, 545, 495, 10.1038/nature22396
Hennessy, 2013, Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582), J. Med. Chem., 56, 9897, 10.1021/jm401075x
Hildner, 2008, Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity, Science, 322, 1097, 10.1126/science.1164206
Hoves, 2018, Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity, J. Exp. Med., 215, 859, 10.1084/jem.20171440
Huang, 2017, T-cell invigoration to tumour burden ratio associated with anti-PD-1 response, Nature, 545, 60, 10.1038/nature22079
Hui, 2017, T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition, Science, 355, 1428, 10.1126/science.aaf1292
Joshi, 2007, Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor, Immunity, 27, 281, 10.1016/j.immuni.2007.07.010
Kamphorst, 2017, Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent, Science, 355, 1423, 10.1126/science.aaf0683
Kao, 2011, Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection, Nat. Immunol., 12, 663, 10.1038/ni.2046
Katakam, 2015, Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells, Proc. Natl. Acad. Sci. USA, 112, 14664, 10.1073/pnas.1520627112
Keir, 2008, PD-1 and its ligands in tolerance and immunity, Annu. Rev. Immunol., 26, 677, 10.1146/annurev.immunol.26.021607.090331
Lasek, 2014, Interleukin 12: still a promising candidate for tumor immunotherapy?, Cancer Immunol. Immunother., 63, 419, 10.1007/s00262-014-1523-1
Lee, 2013, Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1), J. Immunol., 191, 4223, 10.4049/jimmunol.1300910
Lind, 2008, Dendritic cells require the NF-kappaB2 pathway for cross-presentation of soluble antigens, J. Immunol., 181, 354, 10.4049/jimmunol.181.1.354
Ma, 1996, The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells, J. Exp. Med., 183, 147, 10.1084/jem.183.1.147
Macosko, 2015, Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets, Cell, 161, 1202, 10.1016/j.cell.2015.05.002
MartIn-Fontecha, 2003, Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming, J. Exp. Med., 198, 615, 10.1084/jem.20030448
Marty, 2017, MHC-I genotype restricts the oncogenic mutational landscape, Cell, 171, 1272, 10.1016/j.cell.2017.09.050
Matson, 2018, The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients, Science, 359, 104, 10.1126/science.aao3290
McGranahan, 2017, Allele-specific HLA loss and immune escape in lung cancer evolution, Cell, 171, 1259, 10.1016/j.cell.2017.10.001
Meredith, 2012, Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage, J. Exp. Med., 209, 1153, 10.1084/jem.20112675
Nastala, 1994, Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production, J. Immunol., 153, 1697, 10.4049/jimmunol.153.4.1697
Ngiow, 2016, Agonistic CD40 mAb-driven IL12 reverses resistance to anti-PD1 in a T-cell-rich tumor, Cancer Res., 76, 6266, 10.1158/0008-5472.CAN-16-2141
Nirschl, 2017, IFNγ-dependent tissue-immune homeostasis is co-opted in the tumor microenvironment, Cell, 170, 127, 10.1016/j.cell.2017.06.016
Paley, 2012, Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection, Science, 338, 1220, 10.1126/science.1229620
Pittet, 2018, Recording the wild lives of immune cells, Sci. Immunol., 3, 3, 10.1126/sciimmunol.aaq0491
Reinhardt, 2006, Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation, J. Immunol., 177, 1618, 10.4049/jimmunol.177.3.1618
Reinhardt, 2015, A novel model for IFN-γ-mediated autoinflammatory syndromes, J. Immunol., 194, 2358, 10.4049/jimmunol.1401992
Riaz, 2017, Tumor and microenvironment evolution during immunotherapy with nivolumab, Cell, 171, 934, 10.1016/j.cell.2017.09.028
Rizvi, 2015, Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer, Science, 348, 124, 10.1126/science.aaa1348
Rooney, 2015, Molecular and genetic properties of tumors associated with local immune cytolytic activity, Cell, 160, 48, 10.1016/j.cell.2014.12.033
Routy, 2018, Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science, 359, 91, 10.1126/science.aan3706
Ruffell, 2014, Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells, Cancer Cell, 26, 623, 10.1016/j.ccell.2014.09.006
Salmon, 2016, Expansion and activation of CD103(+) dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition, Immunity, 44, 924, 10.1016/j.immuni.2016.03.012
Satija, 2015, Spatial reconstruction of single-cell gene expression data, Nat. Biotechnol., 33, 495, 10.1038/nbt.3192
Schlitzer, 2014, Organization of the mouse and human DC network, Curr. Opin. Immunol., 26, 90, 10.1016/j.coi.2013.11.002
Schreiber, 2011, Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion, Science, 331, 1565, 10.1126/science.1203486
Slifka, 1999, Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells, Nature, 401, 76, 10.1038/43454
Spranger, 2014, Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment, J. Immunother. Cancer, 2, 3, 10.1186/2051-1426-2-3
Spranger, 2015, Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity, Nature, 523, 231, 10.1038/nature14404
Szabo, 2000, A novel transcription factor, T-bet, directs Th1 lineage commitment, Cell, 100, 655, 10.1016/S0092-8674(00)80702-3
Takemoto, 2006, Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation, J. Immunol., 177, 7515, 10.4049/jimmunol.177.11.7515
Thurber, 2013, Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo, Nat. Commun., 4, 1504, 10.1038/ncomms2506
Topalian, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N. Engl. J. Med., 366, 2443, 10.1056/NEJMoa1200690
Weinreb, 2018, SPRING: a kinetic interface for visualizing high dimensional single-cell expression data, Bioinformatics, 34, 1246, 10.1093/bioinformatics/btx792
