Subclinical inner retinal layer thickness changes in the fellow eyes of patients with unilateral central retinal artery occlusion: a pilot study

International Ophthalmology - 2020
Enver Mirza1, Gunsu Deniz Mirza1, Refik Oltulu1, Selman Belviranli1, Hurkan Kerimoglu1
1Meram Faculty of Medicine, Department of Ophthalmology, Necmettin Erbakan University, Meram, Turkey

Tóm tắt

To investigate microstructural changes in the macular inner retinal layers over time in the fellow eyes of patients with unilateral central retinal artery occlusion (CRAO). Spectral-domain optical coherence tomography scans of 16 patients with CRAO were performed at initial examination (1st day), at 1st month, at 3rd month, at 6th month, and the central macular thickness (CMT) and inner retinal layer thicknesses in the fellow eyes of the patients were compared between each visit. The thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL) were calculated in 9 quadrants according to the definition by the Early Treatment Diabetic Retinopathy Study. CMT decreased over a 6-month period, but the difference was insignificant among visits (p = 0.072). Also, there were no significant differences in the thicknesses of RNFL and GCL among visits (p > 0.05 for all quadrants). But there was thinning in the parafoveal superior and perifoveal superior quadrants of the IPL (p = 0.007, p = 0.01) and in the parafoveal temporal quadrant of the INL (p = 0.033) within 6 months of follow-up in the fellow eyes of the patients with CRAO. This study demonstrated subclinical alterations of the macular inner retinal layers over time in the fellow eyes of CRAO patients.

Từ khóa


Tài liệu tham khảo

Varma DD, Cugati S, Lee AW, Chen CS (2013) A review of central retinal artery occlusion: clinical presentation and management. Eye Lond 27(6):688–697

Singh S, Dass R (1960) The central artery of the retina. I. Origin and course. Br J Ophthalmol 44(4):193–212

Hayreh SS, Podhajsky PA, Zimmerman MB (2009) Retinal artery occlusion: associated systemic and ophthalmic abnormalities. Ophthalmology 116(10):1928–1936

Falkenberry SM, Ip MS, Blodi BA (2006) Gunther JB (2006) Optical coherence tomography findings in central retinal artery occlusion. Ophthalmic Surg Lasers Imaging 37:502–505

Hayreh SS, Jonas JB (2000) Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. Am J Ophthalmol 129:786–795

Hayreh SS, Zimmerman MB, Kimura A, Sanon A (2004) Central retinal artery occlusion. Retinal survival time. Exp Eye Res 78:723–736

Ahn SJ, Woo SJ, Park KH, Jung C, Hong JH, Han MK (2015) Retinal and choroidal changes and visual outcome in central retinal artery occlusion: an optical coherence tomography Study. Am J Ophthalmol 159:667–676

Ozdemir H, Karacorlu S, Karacorlu M (2006) Optical coherence tomography findings in central retinal artery occlusion. Retina 26:110–112

Hayreh SS (2011) Acute retinal arterial occlusive disorders. Prog Retin Eye Res 30:359–394

Kim YH, Park KH, Woo SJ (2020) Clinical manifestations and visual prognosis of cilioretinal artery sparing central retinal artery occlusion. Korean J Ophthalmol 34(1):27–34. https://doi.org/10.3341/kjo.2019.0099

Napoli PE, Cuccu A, Farci R, Fossarello M (2016) Simultaneous occlusion of three cilioretinal arteries following scleral buckling surgery under local anesthesia. Int Med Case Rep J 9:285–290. https://doi.org/10.2147/IMCRJ.S111682

Pichi F, Fragiotta S, Freund KB et al (2019) Cilioretinal artery hypoperfusion and its association with paracentral acute middle maculopathy. Br J Ophthalmol 103:1137–1145

Çetinkaya E, Duman R, Duman R, Sabaner MC (2017) Repeatability and reproducibility of automatic segmentation of retinal layers in healthy subjects using Spectralis optical coherence tomography. Arq Bras Oftalmol 80(6):378–381

Fujimoto JG, Pitris C, Boppart SA, Brezinski ME (2000) Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia 2(1–2):9–25

Matthé E, Eulitz P, Furashova O (2019) Acute retinal ıschemia in central versus branch retinal artery occlusion: changes in retinal layers’ thickness on spectral-domain optical coherence tomography in different grades of retinal ıschemia. Retina 00:1–6

Ritter M, Sacu S, Deák GG, Kircher K, Sayegh RG, Pruente C, Schmidt-Erfurth UM (2012) In vivo identification of alteration of inner neurosensory layers in branch retinal artery occlusion. Br J Ophthalmol 96(2):201–207

Chen SN, Hwang JF, Chen YT (2011) Macular thickness measurements in central retinal artery occlusion by optical coherence tomography. Retina 31:730–737

Leung CK, Tham CC, Mohammed S, Li EY, Leung KS, Chan WM, Lam DS (2007) In vivo measurements of macular and nerve fibre layer thickness in retinal arterial occlusion. Eye Lond 21(12):1464–1468

Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P, Kowalski JW, Nguyen H, Wong TY, International Eye Disease Consortium (2010) The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 117(2):313–9.e1

Cetin EN, Bozkurt K, Parca O, Pekel G (2019) Automated macular segmentation with spectral domain optical coherence tomography in the fellow eyes of patients with unilateral retinal vein occlusion. Int Ophthalmol 39(9):2049–2056

Kim MJ, Woo SJ, Park KH, Kim TW (2011) Retinal nerve fiber layer thickness is decreased in the fellow eyes of patients with unilateral retinal vein occlusion. Ophthalmology 118(4):706–710

Adhi M, Filho MA, Louzada RN, Kuehlewein L, de Carlo TE, Baumal CR, Witkin AJ, Sadda SR, Sarraf D, Reichel E et al (2016) Retinal capillary network and foveal avascular zone in eyes with vein occlusion and fellow eyes analyzed with optical coherence tomography angiography. Invest Ophthalmol Vis Sci 57(9):486–494

Timoney PJ, Pate JC, Pearson PA, Crandall J (2009) Bilateral central retinal artery occlusion in a patient with acute pancreatitis. Retin Cases Brief Rep 3(3):308–309. https://doi.org/10.1097/ICB.0b013e31818c5de0

Akiyama Y, Shinoda K, Watanabe E, Mashiko T, Mizota A (2012) Simultaneous bilateral central retinal artery occlusion in churg-strauss syndrome. Retin Cases Brief Rep 6(1):60–64. https://doi.org/10.1097/ICB.0b013e3182051ee7

Padrón-Pérez N, Aronés JR, Muñoz S, Arias-Barquet L, Arruga J (2014) Sequential bilateral retinal artery occlusion. Clin Ophthalmol 8:733–738. https://doi.org/10.2147/OPTH.S56568

Zou X, Zhuang Y, Dong FT, Zhang F, Chen YX (2012) Sequential bilateral central retinal artery occlusion as the primary manifestation of systemic lupus erythematosus. Chin Med J (Engl) 125(8):1517–1519

Lee AY, Zhang Q, Baughman DM, Mudumbai R, Wang RK, Lee CS (2016) Evaluation of bilateral central retinal artery occlusions with optical coherence tomography-based microangiography: a case report. J Med Case Rep 10(1):307

Guo T, Zhang HR (2011) Clinical features and carotid artery color Doppler imaging in patients with ocular ischemic syndrome. Zhonghua Yan Ke Za Zhi 47(3):228–234

Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol 27:165–197

Thông tin
Thông tin xuất bản

International Ophthalmology

Thông tin tác giả